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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ACE_HUMAN (P12821)

Summary

This is the summary of UniProt entry ACE_HUMAN (P12821).

Description: Angiotensin-converting enzyme EC=3.2.1.- EC=3.4.15.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1306 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 29
low_complexity n/a 9 37
Pfam A Peptidase_M2 31 630
disorder n/a 32 36
disorder n/a 80 81
Pfam A Peptidase_M2 634 1228
disorder n/a 637 640
disorder n/a 1230 1233
transmembrane n/a 1260 1281
low_complexity n/a 1261 1274
low_complexity n/a 1279 1293

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P12821. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGAASGRRGP GLLLPLPLLL LLPPQPALAL DPGLQPGNFS ADEAGAQLFA
50
51
QSYNSSAEQV LFQSVAASWA HDTNITAENA RRQEEAALLS QEFAEAWGQK
100
101
AKELYEPIWQ NFTDPQLRRI IGAVRTLGSA NLPLAKRQQY NALLSNMSRI
150
151
YSTAKVCLPN KTATCWSLDP DLTNILASSR SYAMLLFAWE GWHNAAGIPL
200
201
KPLYEDFTAL SNEAYKQDGF TDTGAYWRSW YNSPTFEDDL EHLYQQLEPL
250
251
YLNLHAFVRR ALHRRYGDRY INLRGPIPAH LLGDMWAQSW ENIYDMVVPF
300
301
PDKPNLDVTS TMLQQGWNAT HMFRVAEEFF TSLELSPMPP EFWEGSMLEK
350
351
PADGREVVCH ASAWDFYNRK DFRIKQCTRV TMDQLSTVHH EMGHIQYYLQ
400
401
YKDLPVSLRR GANPGFHEAI GDVLALSVST PEHLHKIGLL DRVTNDTESD
450
451
INYLLKMALE KIAFLPFGYL VDQWRWGVFS GRTPPSRYNF DWWYLRTKYQ
500
501
GICPPVTRNE THFDAGAKFH VPNVTPYIRY FVSFVLQFQF HEALCKEAGY
550
551
EGPLHQCDIY RSTKAGAKLR KVLQAGSSRP WQEVLKDMVG LDALDAQPLL
600
601
KYFQPVTQWL QEQNQQNGEV LGWPEYQWHP PLPDNYPEGI DLVTDEAEAS
650
651
KFVEEYDRTS QVVWNEYAEA NWNYNTNITT ETSKILLQKN MQIANHTLKY
700
701
GTQARKFDVN QLQNTTIKRI IKKVQDLERA ALPAQELEEY NKILLDMETT
750
751
YSVATVCHPN GSCLQLEPDL TNVMATSRKY EDLLWAWEGW RDKAGRAILQ
800
801
FYPKYVELIN QAARLNGYVD AGDSWRSMYE TPSLEQDLER LFQELQPLYL
850
851
NLHAYVRRAL HRHYGAQHIN LEGPIPAHLL GNMWAQTWSN IYDLVVPFPS
900
901
APSMDTTEAM LKQGWTPRRM FKEADDFFTS LGLLPVPPEF WNKSMLEKPT
950
951
DGREVVCHAS AWDFYNGKDF RIKQCTTVNL EDLVVAHHEM GHIQYFMQYK
1000
1001
DLPVALREGA NPGFHEAIGD VLALSVSTPK HLHSLNLLSS EGGSDEHDIN
1050
1051
FLMKMALDKI AFIPFSYLVD QWRWRVFDGS ITKENYNQEW WSLRLKYQGL
1100
1101
CPPVPRTQGD FDPGAKFHIP SSVPYIRYFV SFIIQFQFHE ALCQAAGHTG
1150
1151
PLHKCDIYQS KEAGQRLATA MKLGFSRPWP EAMQLITGQP NMSASAMLSY
1200
1201
FKPLLDWLRT ENELHGEKLG WPQYNWTPNS ARSEGPLPDS GRVSFLGLDL
1250
1251
DAQQARVGQW LLLFLGIALL VATLGLSQRL FSIRHRSLHR HSHGPQFGSE
1300
1301
VELRHS                                                
1306
 

Show the unformatted sequence.

Checksums:
CRC64:1B33BCA7301A26AA
MD5:24dbb41b5e1405871d2cdb516842de5b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_M2 31 - 630 2C6F A 2 - 601 Jmol AstexViewer SPICE
B 2 - 601 Jmol AstexViewer SPICE
2C6N A 2 - 601 Jmol AstexViewer SPICE
B 2 - 601 Jmol AstexViewer SPICE
2XYD A 2 - 601 Jmol AstexViewer SPICE
B 2 - 601 Jmol AstexViewer SPICE
3NXQ A 2 - 601 Jmol AstexViewer SPICE
B 2 - 601 Jmol AstexViewer SPICE
634 - 639 2XYD A 605 - 610 Jmol AstexViewer SPICE
B 605 - 610 Jmol AstexViewer SPICE
3NXQ A 605 - 610 Jmol AstexViewer SPICE
B 605 - 610 Jmol AstexViewer SPICE
634 - 640 2C6N B 605 - 611 Jmol AstexViewer SPICE
634 - 641 2C6F A 605 - 612 Jmol AstexViewer SPICE
B 605 - 612 Jmol AstexViewer SPICE
2C6N A 605 - 612 Jmol AstexViewer SPICE
643 - 1228 3BKK A 38 - 623 Jmol AstexViewer SPICE
645 - 1222 2IUX A 40 - 617 Jmol AstexViewer SPICE
3L3N A 40 - 617 Jmol AstexViewer SPICE
645 - 1223 1O86 A 40 - 618 Jmol AstexViewer SPICE
1O8A A 40 - 618 Jmol AstexViewer SPICE
1UZE A 40 - 618 Jmol AstexViewer SPICE
1UZF A 40 - 618 Jmol AstexViewer SPICE
2YDM A 40 - 618 Jmol AstexViewer SPICE
645 - 1228 2IUL A 40 - 623 Jmol AstexViewer SPICE
2OC2 A 40 - 623 Jmol AstexViewer SPICE
2XY9 A 40 - 623 Jmol AstexViewer SPICE
3BKL A 40 - 623 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.