Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
29  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FPPS_HUMAN (P14324)

Summary

This is the summary of UniProt entry FPPS_HUMAN (P14324).

Description: Farnesyl pyrophosphate synthase EC=2.5.1.10 EC=2.5.1.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 419 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam B Pfam-B_25387 1 69
transmembrane n/a 6 22
Pfam A polyprenyl_synt 110 382
transmembrane n/a 267 285

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P14324. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLSRWLRSV GVFLLPAPYW APRERWLGSL RRPSLVHGYP VLAWHSARCW
50
51
CQAWTEEPRA LCSSLRMNGD QNSDVYAQEK QDFVQHFSQI VRVLTEDEMG
100
101
HPEIGDAIAR LKEVLEYNAI GGKYNRGLTV VVAFRELVEP RKQDADSLQR
150
151
AWTVGWCVEL LQAFFLVADD IMDSSLTRRG QICWYQKPGV GLDAINDANL
200
201
LEACIYRLLK LYCREQPYYL NLIELFLQSS YQTEIGQTLD LLTAPQGNVD
250
251
LVRFTEKRYK SIVKYKTAFY SFYLPIAAAM YMAGIDGEKE HANAKKILLE
300
301
MGEFFQIQDD YLDLFGDPSV TGKIGTDIQD NKCSWLVVQC LQRATPEQYQ
350
351
ILKENYGQKE AEKVARVKAL YEELDLPAVF LQYEEDSYSH IMALIEQYAA
400
401
PLPPAVFLGL ARKIYKRRK                                  
419
 

Show the unformatted sequence.

Checksums:
CRC64:52934B80A808FB67
MD5:d1fd398e425c19f72605225485301565

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
polyprenyl_synt 110 - 382 1YQ7 A 58 - 330 Jmol AstexViewer SPICE
1YV5 A 58 - 330 Jmol AstexViewer SPICE
1ZW5 A 58 - 330 Jmol AstexViewer SPICE
2F7M F 44 - 316 Jmol AstexViewer SPICE
2F89 F 44 - 316 Jmol AstexViewer SPICE
2F8C F 44 - 316 Jmol AstexViewer SPICE
2F8Z F 44 - 316 Jmol AstexViewer SPICE
2F92 F 44 - 316 Jmol AstexViewer SPICE
2F94 F 44 - 316 Jmol AstexViewer SPICE
2F9K F 44 - 316 Jmol AstexViewer SPICE
2OPM A 58 - 330 Jmol AstexViewer SPICE
2OPN A 58 - 330 Jmol AstexViewer SPICE
2QIS A 58 - 330 Jmol AstexViewer SPICE
2RAH A 44 - 316 Jmol AstexViewer SPICE
2VF6 A 44 - 316 Jmol AstexViewer SPICE
3B7L A 44 - 316 Jmol AstexViewer SPICE
3CP6 A 44 - 316 Jmol AstexViewer SPICE
3N1V F 44 - 316 Jmol AstexViewer SPICE
3N1W F 44 - 316 Jmol AstexViewer SPICE
3N3L F 44 - 316 Jmol AstexViewer SPICE
3N45 F 44 - 316 Jmol AstexViewer SPICE
3N46 F 44 - 316 Jmol AstexViewer SPICE
3N49 F 44 - 316 Jmol AstexViewer SPICE
3N5H F 44 - 316 Jmol AstexViewer SPICE
3N5J F 44 - 316 Jmol AstexViewer SPICE
3N6K F 44 - 316 Jmol AstexViewer SPICE
3RYE A 44 - 316 Jmol AstexViewer SPICE
3S4J A 44 - 316 Jmol AstexViewer SPICE
4DEM F 58 - 330 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.