Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
106  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ALDR_HUMAN (P15121)

Summary

This is the summary of UniProt entry ALDR_HUMAN (P15121).

Description: Aldose reductase EC=1.1.1.21
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 316 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Aldo_ket_red 15 294
low_complexity n/a 97 109
disorder n/a 221 222
disorder n/a 224 225

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P15121. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ
50
51
NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL
100
101
KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD
150
151
EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC
200
201
QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK HNKTTAQVLI
250
251
RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA
300
301
LLSCTSHKDY PFHEEF                                     
316
 

Show the unformatted sequence.

Checksums:
CRC64:1852E8616B5DCEAE
MD5:b9cb1c8f66b09e25b16b9059983374e3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Aldo_ket_red 15 - 294 1ADS A 14 - 293 Jmol AstexViewer SPICE
1AZ1 A 14 - 293 Jmol AstexViewer SPICE
1AZ2 A 14 - 293 Jmol AstexViewer SPICE
1EF3 A 14 - 293 Jmol AstexViewer SPICE
B 14 - 293 Jmol AstexViewer SPICE
1EL3 A 14 - 293 Jmol AstexViewer SPICE
1IEI A 14 - 293 Jmol AstexViewer SPICE
1PWL A 14 - 293 Jmol AstexViewer SPICE
1PWM A 14 - 293 Jmol AstexViewer SPICE
1T40 A 14 - 293 Jmol AstexViewer SPICE
1T41 A 14 - 293 Jmol AstexViewer SPICE
1US0 A 14 - 293 Jmol AstexViewer SPICE
1X96 A 14 - 293 Jmol AstexViewer SPICE
1X97 A 14 - 293 Jmol AstexViewer SPICE
1X98 A 14 - 293 Jmol AstexViewer SPICE
1XGD A 14 - 293 Jmol AstexViewer SPICE
1Z3N A 14 - 293 Jmol AstexViewer SPICE
1Z89 A 14 - 293 Jmol AstexViewer SPICE
1Z8A A 14 - 293 Jmol AstexViewer SPICE
2ACQ A 14 - 293 Jmol AstexViewer SPICE
2ACR A 14 - 293 Jmol AstexViewer SPICE
2ACS A 14 - 293 Jmol AstexViewer SPICE
2ACU A 14 - 293 Jmol AstexViewer SPICE
2AGT A 14 - 293 Jmol AstexViewer SPICE
2DUX A 14 - 293 Jmol AstexViewer SPICE
2DUZ A 14 - 293 Jmol AstexViewer SPICE
2DV0 A 14 - 293 Jmol AstexViewer SPICE
2F2K A 14 - 293 Jmol AstexViewer SPICE
2FZ8 A 14 - 293 Jmol AstexViewer SPICE
2FZ9 A 14 - 293 Jmol AstexViewer SPICE
2FZB A 14 - 293 Jmol AstexViewer SPICE
2FZD A 14 - 293 Jmol AstexViewer SPICE
2HV5 A 14 - 293 Jmol AstexViewer SPICE
2HVN A 14 - 293 Jmol AstexViewer SPICE
2HVO A 14 - 293 Jmol AstexViewer SPICE
2I16 A 15 - 294 Jmol AstexViewer SPICE
2I17 A 15 - 294 Jmol AstexViewer SPICE
2IKG A 14 - 293 Jmol AstexViewer SPICE
2IKH A 14 - 293 Jmol AstexViewer SPICE
2IKI A 14 - 293 Jmol AstexViewer SPICE
2IKJ A 14 - 293 Jmol AstexViewer SPICE
2INE A 14 - 293 Jmol AstexViewer SPICE
2INZ A 14 - 293 Jmol AstexViewer SPICE
2IPW A 14 - 293 Jmol AstexViewer SPICE
2IQ0 A 14 - 293 Jmol AstexViewer SPICE
2IQD A 14 - 293 Jmol AstexViewer SPICE
2IS7 A 14 - 293 Jmol AstexViewer SPICE
2ISF A 14 - 293 Jmol AstexViewer SPICE
2J8T A 14 - 293 Jmol AstexViewer SPICE
2NVC A 14 - 293 Jmol AstexViewer SPICE
2NVD A 14 - 293 Jmol AstexViewer SPICE
2PD5 A 14 - 293 Jmol AstexViewer SPICE
2PD9 A 14 - 293 Jmol AstexViewer SPICE
2PDB A 14 - 293 Jmol AstexViewer SPICE
2PDC A 14 - 293 Jmol AstexViewer SPICE
2PDF A 14 - 293 Jmol AstexViewer SPICE
2PDG A 14 - 293 Jmol AstexViewer SPICE
2PDH A 14 - 293 Jmol AstexViewer SPICE
2PDI A 14 - 293 Jmol AstexViewer SPICE
2PDJ A 14 - 293 Jmol AstexViewer SPICE
2PDK A 14 - 293 Jmol AstexViewer SPICE
2PDL A 14 - 293 Jmol AstexViewer SPICE
2PDM A 14 - 293 Jmol AstexViewer SPICE
2PDN A 14 - 293 Jmol AstexViewer SPICE
2PDP A 14 - 293 Jmol AstexViewer SPICE
2PDQ A 14 - 293 Jmol AstexViewer SPICE
2PDU A 14 - 293 Jmol AstexViewer SPICE
2PDW A 14 - 293 Jmol AstexViewer SPICE
2PDX A 14 - 293 Jmol AstexViewer SPICE
2PDY A 14 - 293 Jmol AstexViewer SPICE
2PEV A 14 - 293 Jmol AstexViewer SPICE
2PF8 A 14 - 293 Jmol AstexViewer SPICE
2PFH A 14 - 293 Jmol AstexViewer SPICE
2PZN A 14 - 293 Jmol AstexViewer SPICE
2QXW A 14 - 293 Jmol AstexViewer SPICE
2R24 A 14 - 293 Jmol AstexViewer SPICE
3BCJ A 14 - 293 Jmol AstexViewer SPICE
3DN5 A 14 - 293 Jmol AstexViewer SPICE
3G5E A 14 - 293 Jmol AstexViewer SPICE
3GHR A 14 - 293 Jmol AstexViewer SPICE
3GHS A 14 - 293 Jmol AstexViewer SPICE
3GHT A 14 - 293 Jmol AstexViewer SPICE
3GHU A 14 - 293 Jmol AstexViewer SPICE
3LBO A 14 - 293 Jmol AstexViewer SPICE
3LD5 A 14 - 293 Jmol AstexViewer SPICE
3LEN A 14 - 293 Jmol AstexViewer SPICE
3LEP A 14 - 293 Jmol AstexViewer SPICE
3LQG A 14 - 293 Jmol AstexViewer SPICE
3LQL A 15 - 294 Jmol AstexViewer SPICE
3LZ3 A 14 - 293 Jmol AstexViewer SPICE
3LZ5 A 14 - 293 Jmol AstexViewer SPICE
3M0I A 14 - 293 Jmol AstexViewer SPICE
3M4H A 14 - 293 Jmol AstexViewer SPICE
3M64 A 14 - 293 Jmol AstexViewer SPICE
3MB9 A 14 - 293 Jmol AstexViewer SPICE
3MC5 A 14 - 293 Jmol AstexViewer SPICE
3ONB A 14 - 293 Jmol AstexViewer SPICE
3ONC A 14 - 293 Jmol AstexViewer SPICE
3P2V A 14 - 293 Jmol AstexViewer SPICE
3Q65 A 14 - 293 Jmol AstexViewer SPICE
B 14 - 293 Jmol AstexViewer SPICE
3Q67 A 14 - 293 Jmol AstexViewer SPICE
B 14 - 293 Jmol AstexViewer SPICE
3RX2 A 14 - 293 Jmol AstexViewer SPICE
3RX3 A 14 - 293 Jmol AstexViewer SPICE
3RX4 A 14 - 293 Jmol AstexViewer SPICE
3S3G A 14 - 293 Jmol AstexViewer SPICE
3T42 A 14 - 293 Jmol AstexViewer SPICE
3U2C A 14 - 293 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.