Summary
This is the summary of UniProt entry DESP_HUMAN (P15924).
| Description: | Desmoplakin |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 2871 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 2 |
| disorder | n/a | 12 | 18 |
| disorder | n/a | 22 | 23 |
| disorder | n/a | 25 | 31 |
| disorder | n/a | 41 | 44 |
| disorder | n/a | 53 | 63 |
| disorder | n/a | 68 | 69 |
| coiled_coil | n/a | 135 | 155 |
| low_complexity | n/a | 166 | 179 |
| coiled_coil | n/a | 319 | 339 |
| low_complexity | n/a | 319 | 332 |
| coiled_coil | n/a | 411 | 441 |
| low_complexity | n/a | 414 | 433 |
| disorder | n/a | 602 | 607 |
| low_complexity | n/a | 631 | 647 |
| disorder | n/a | 634 | 643 |
| disorder | n/a | 646 | 658 |
| Pfam B | Pfam-B_19004 | 771 | 816 |
| low_complexity | n/a | 811 | 825 |
| disorder | n/a | 937 | 938 |
| Pfam B | Pfam-B_18261 | 983 | 1027 |
| coiled_coil | n/a | 1027 | 1047 |
| coiled_coil | n/a | 1055 | 1096 |
| coiled_coil | n/a | 1104 | 1152 |
| disorder | n/a | 1125 | 1136 |
| disorder | n/a | 1139 | 1141 |
| low_complexity | n/a | 1159 | 1172 |
| coiled_coil | n/a | 1171 | 1209 |
| disorder | n/a | 1187 | 1212 |
| low_complexity | n/a | 1209 | 1224 |
| disorder | n/a | 1217 | 1242 |
| coiled_coil | n/a | 1225 | 1273 |
| disorder | n/a | 1261 | 1283 |
| coiled_coil | n/a | 1288 | 1365 |
| disorder | n/a | 1291 | 1322 |
| disorder | n/a | 1324 | 1330 |
| disorder | n/a | 1345 | 1347 |
| disorder | n/a | 1373 | 1400 |
| coiled_coil | n/a | 1388 | 1436 |
| disorder | n/a | 1402 | 1404 |
| disorder | n/a | 1406 | 1414 |
| disorder | n/a | 1416 | 1418 |
| disorder | n/a | 1420 | 1453 |
| disorder | n/a | 1460 | 1472 |
| coiled_coil | n/a | 1466 | 1548 |
| disorder | n/a | 1476 | 1477 |
| disorder | n/a | 1484 | 1488 |
| disorder | n/a | 1494 | 1495 |
| disorder | n/a | 1497 | 1498 |
| disorder | n/a | 1500 | 1502 |
| disorder | n/a | 1510 | 1516 |
| disorder | n/a | 1521 | 1523 |
| disorder | n/a | 1525 | 1528 |
| coiled_coil | n/a | 1556 | 1681 |
| low_complexity | n/a | 1563 | 1577 |
| disorder | n/a | 1579 | 1582 |
| disorder | n/a | 1584 | 1586 |
| disorder | n/a | 1588 | 1598 |
| disorder | n/a | 1626 | 1627 |
| disorder | n/a | 1635 | 1645 |
| disorder | n/a | 1647 | 1652 |
| disorder | n/a | 1655 | 1656 |
| disorder | n/a | 1672 | 1673 |
| disorder | n/a | 1675 | 1677 |
| disorder | n/a | 1679 | 1684 |
| disorder | n/a | 1686 | 1689 |
| coiled_coil | n/a | 1689 | 1744 |
| low_complexity | n/a | 1718 | 1736 |
| disorder | n/a | 1735 | 1738 |
| disorder | n/a | 1742 | 1746 |
| coiled_coil | n/a | 1763 | 1804 |
| disorder | n/a | 1795 | 1796 |
| coiled_coil | n/a | 1812 | 1919 |
| disorder | n/a | 1833 | 1834 |
| disorder | n/a | 1840 | 1841 |
| disorder | n/a | 1878 | 1894 |
| low_complexity | n/a | 1879 | 1898 |
| low_complexity | n/a | 1905 | 1918 |
| disorder | n/a | 1920 | 1935 |
| coiled_coil | n/a | 1925 | 1945 |
| disorder | n/a | 1939 | 1947 |
| disorder | n/a | 1951 | 1955 |
| low_complexity | n/a | 1985 | 1999 |
| low_complexity | n/a | 2014 | 2024 |
| Pfam A | Plectin | 2046 | 2090 |
| Pfam A | Plectin | 2122 | 2166 |
| disorder | n/a | 2170 | 2171 |
| Pfam A | Plectin | 2251 | 2294 |
| low_complexity | n/a | 2288 | 2297 |
| Pfam A | Plectin | 2289 | 2333 |
| Pfam A | Plectin | 2365 | 2409 |
| disorder | n/a | 2408 | 2417 |
| Pfam A | Plectin | 2458 | 2500 |
| low_complexity | n/a | 2495 | 2505 |
| low_complexity | n/a | 2566 | 2585 |
| low_complexity | n/a | 2606 | 2617 |
| Pfam A | Plectin | 2648 | 2692 |
| Pfam A | Plectin | 2724 | 2768 |
| disorder | n/a | 2813 | 2850 |
| low_complexity | n/a | 2824 | 2849 |
| low_complexity | n/a | 2856 | 2868 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P15924. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSCNGGSHPR INTLGRMIRA ESGPDLRYEV TSGGGGTSRM YYSRRGVITD
50 51
QNSDGYCQTG TMSRHQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ
100 101
LTRSRELDEC FAQANDQMEI LDSLIREMRQ MGQPCDAYQK RLLQLQEQMR
150 151
ALYKAISVPR VRRASSKGGG GYTCQSGSGW DEFTKHVTSE CLGWMRQQRA
200 201
EMDMVAWGVD LASVEQHINS HRGIHNSIGD YRWQLDKIKA DLREKSAIYQ
250 251
LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE EEELLYDWSD
300 301
KNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ HPASDKIEAY
350 351
MDTLQTQWSW ILQITKCIDV HLKENAAYFQ FFEEAQSTEA YLKGLQDSIR
400 401
KKYPCDKNMP LQHLLEQIKE LEKEREKILE YKRQVQNLVN KSKKIVQLKP
450 451
RNPDYRSNKP IILRALCDYK QDQKIVHKGD ECILKDNNER SKWYVTGPGG
500 501
VDMLVPSVGL IIPPPNPLAV DLSCKIEQYY EAILALWNQL YINMKSLVSW
550 551
HYCMIDIEKI RAMTIAKLKT MRQEDYMKTI ADLELHYQEF IRNSQGSEMF
600 601
GDDDKRKIQS QFTDAQKHYQ TLVIQLPGYP QHQTVTTTEI THHGTCQDVN
650 651
HNKVIETNRE NDKQETWMLM ELQKIRRQIE HCEGRMTLKN LPLADQGSSH
700 701
HITVKINELK SVQNDSQAIA EVLNQLKDML ANFRGSEKYC YLQNEVFGLF
750 751
QKLENINGVT DGYLNSLCTV RALLQAILQT EDMLKVYEAR LTEEETVCLD
800 801
LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS QTSQQYPLYD
850 851
LDLGKFGEKV TQLTDRWQRI DKQIDFRLWD LEKQIKQLRN YRDNYQAFCK
900 901
WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK RDKSEEVQKI
950 951
AELCANSIKD YELQLASYTS GLETLLNIPI KRTMIQSPSG VILQEAADVH
1000 1001
ARYIELLTRS GDYYRFLSEM LKSLEDLKLK NTKIEVLEEE LRLARDANSE
1050 1051
NCNKNKFLDQ NLQKYQAECS QFKAKLASLE ELKRQAELDG KSAKQNLDKC
1100 1101
YGQIKELNEK ITRLTYEIED EKRRRKSVED RFDQQKNDYD QLQKARQCEK
1150 1151
ENLGWQKLES EKAIKEKEYE IERLRVLLQE EGTRKREYEN ELAKVRNHYN
1200 1201
EEMSNLRNKY ETEINITKTT IKEISMQKED DSKNLRNQLD RLSRENRDLK
1250 1251
DEIVRLNDSI LQATEQRRRA EENALQQKAC GSEIMQKKQH LEIELKQVMQ
1300 1301
QRSEDNARHK QSLEEAAKTI QDKNKEIERL KAEFQEEAKR RWEYENELSK
1350 1351
VRNNYDEEII SLKNQFETEI NITKTTIHQL TMQKEEDTSG YRAQIDNLTR
1400 1401
ENRSLSEEIK RLKNTLTQTT ENLRRVEEDI QQQKATGSEV SQRKQQLEVE
1450 1451
LRQVTQMRTE ESVRYKQSLD DAAKTIQDKN KEIERLKQLI DKETNDRKCL
1500 1501
EDENARLQRV QYDLQKANSS ATETINKLKV QEQELTRLRI DYERVSQERT
1550 1551
VKDQDITRFQ NSLKELQLQK QKVEEELNRL KRTASEDSCK RKKLEEELEG
1600 1601
MRRSLKEQAI KITNLTQQLE QASIVKKRSE DDLRQQRDVL DGHLREKQRT
1650 1651
QEELRRLSSE VEALRRQLLQ EQESVKQAHL RNEHFQKAIE DKSRSLNESK
1700 1701
IEIERLQSLT ENLTKEHLML EEELRNLRLE YDDLRRGRSE ADSDKNATIL
1750 1751
ELRSQLQISN NRTLELQGLI NDLQRERENL RQEIEKFQKQ ALEASNRIQE
1800 1801
SKNQCTQVVQ ERESLLVKIK VLEQDKARLQ RLEDELNRAK STLEAETRVK
1850 1851
QRLECEKQQI QNDLNQWKTQ YSRKEEAIRK IESEREKSER EKNSLRSEIE
1900 1901
RLQAEIKRIE ERCRRKLEDS TRETQSQLET ERSRYQREID KLRQRPYGSH
1950 1951
RETQTECEWT VDTSKLVFDG LRKKVTAMQL YECQLIDKTT LDKLLKGKKS
2000 2001
VEEVASEIQP FLRGAGSIAG ASASPKEKYS LVEAKRKKLI SPESTVMLLE
2050 2051
AQAATGGIID PHRNEKLTVD SAIARDLIDF DDRQQIYAAE KAITGFDDPF
2100 2101
SGKTVSVSEA IKKNLIDRET GMRLLEAQIA SGGVVDPVNS VFLPKDVALA
2150 2151
RGLIDRDLYR SLNDPRDSQK NFVDPVTKKK VSYVQLKERC RIEPHTGLLL
2200 2201
LSVQKRSMSF QGIRQPVTVT ELVDSGILRP STVNELESGQ ISYDEVGERI
2250 2251
KDFLQGSSCI AGIYNETTKQ KLGIYEAMKI GLVRPGTALE LLEAQAATGF
2300 2301
IVDPVSNLRL PVEEAYKRGL VGIEFKEKLL SAERAVTGYN DPETGNIISL
2350 2351
FQAMNKELIE KGHGIRLLEA QIATGGIIDP KESHRLPVDI AYKRGYFNEE
2400 2401
LSEILSDPSD DTKGFFDPNT EENLTYLQLK ERCIKDEETG LCLLPLKEKK
2450 2451
KQVQTSQKNT LRKRRVVIVD PETNKEMSVQ EAYKKGLIDY ETFKELCEQE
2500 2501
CEWEEITITG SDGSTRVVLV DRKTGSQYDI QDAIDKGLVD RKFFDQYRSG
2550 2551
SLSLTQFADM ISLKNGVGTS SSMGSGVSDD VFSSSRHESV SKISTISSVR
2600 2601
NLTIRSSSFS DTLEESSPIA AIFDTENLEK ISITEGIERG IVDSITGQRL
2650 2651
LEAQACTGGI IHPTTGQKLS LQDAVSQGVI DQDMATRLKP AQKAFIGFEG
2700 2701
VKGKKKMSAA EAVKEKWLPY EAGQRFLEFQ YLTGGLVDPE VHGRISTEEA
2750 2751
IRKGFIDGRA AQRLQDTSSY AKILTCPKTK LKISYKDAIN RSMVEDITGL
2800 2801
RLLEAASVSS KGLPSPYNMS SAPGSRSGSR SGSRSGSRSG SRSGSRRGSF
2850 2851
DATGNSSYSY SYSFSSSSIG H
2871
Show the unformatted sequence. |
| Checksums: |
CRC64:5770CC6B4F9F9F7B
MD5:69c2ce4671e721b72833bb1b6e86c4cf
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Plectin | 2251 - 2294 | 1LM7 | A | 2251 - 2294 | Jmol AstexViewer SPICE |
| B | 2251 - 2294 | Jmol AstexViewer SPICE | |||
| 2289 - 2333 | 1LM7 | A | 2289 - 2333 | Jmol AstexViewer SPICE | |
| B | 2289 - 2333 | Jmol AstexViewer SPICE | |||
| 2365 - 2409 | 1LM7 | A | 2365 - 2409 | Jmol AstexViewer SPICE | |
| B | 2365 - 2409 | Jmol AstexViewer SPICE | |||
| 2648 - 2692 | 1LM5 | A | 2648 - 2692 | Jmol AstexViewer SPICE | |
| B | 2648 - 2692 | Jmol AstexViewer SPICE | |||
| 2724 - 2768 | 1LM5 | A | 2724 - 2768 | Jmol AstexViewer SPICE | |
| B | 2724 - 2768 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.