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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LAR_DROME (P16621)

Summary

This is the summary of UniProt entry LAR_DROME (P16621).

Description: Tyrosine-protein phosphatase Lar EC=3.1.3.48
Source organism: Drosophila melanogaster (Fruit fly) (NCBI taxonomy ID 7227)
View Pfam proteome data.
Length: 2029 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 32
low_complexity n/a 14 22
disorder n/a 33 37
Pfam A I-set 36 129
disorder n/a 40 41
disorder n/a 68 73
Pfam A I-set 140 227
disorder n/a 141 145
disorder n/a 191 195
disorder n/a 204 213
disorder n/a 223 224
Pfam A I-set 234 318
disorder n/a 238 240
disorder n/a 268 275
Pfam A fn3 323 404
disorder n/a 403 423
Pfam A fn3 418 503
disorder n/a 434 440
disorder n/a 448 453
disorder n/a 463 474
disorder n/a 500 523
Pfam A fn3 516 598
disorder n/a 532 534
disorder n/a 595 608
Pfam A fn3 612 697
disorder n/a 614 615
low_complexity n/a 617 628
disorder n/a 696 717
Pfam A fn3 710 800
disorder n/a 719 721
disorder n/a 727 728
disorder n/a 789 790
disorder n/a 801 807
disorder n/a 815 816
Pfam A fn3 822 898
disorder n/a 864 866
disorder n/a 868 870
disorder n/a 897 908
disorder n/a 910 916
Pfam A fn3 911 995
Pfam A fn3 1008 1092
disorder n/a 1009 1014
Pfam A fn3 1103 1197
disorder n/a 1198 1199
disorder n/a 1203 1204
disorder n/a 1265 1270
disorder n/a 1272 1280
disorder n/a 1343 1368
transmembrane n/a 1378 1402
disorder n/a 1409 1444
disorder n/a 1460 1462
disorder n/a 1474 1475
disorder n/a 1489 1494
Pfam A Y_phosphatase 1497 1728
disorder n/a 1500 1502
Pfam B Pfam-B_4051 1744 1780
Pfam A Y_phosphatase 1786 2019

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P16621. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGLQMTAARP IAALSLLVLS LLTWTHPTIV DAAHPPEIIR KPQNQGVRVG
50
51
GVASFYCAAR GDPPPSIVWR KNGKKVSGTQ SRYTVLEQPG GISILRIEPV
100
101
RAGRDDAPYE CVAENGVGDA VSADATLTIY EGDKTPAGFP VITQGPGTRV
150
151
IEVGHTVLMT CKAIGNPTPN IYWIKNQTKV DMSNPRYSLK DGFLQIENSR
200
201
EEDQGKYECV AENSMGTEHS KATNLYVKVR RVPPTFSRPP ETISEVMLGS
250
251
NLNLSCIAVG SPMPHVKWMK GSEDLTPENE MPIGRNVLQL INIQESANYT
300
301
CIAASTLGQI DSVSVVKVQS LPTAPTDVQI SEVTATSVRL EWSYKGPEDL
350
351
QYYVIQYKPK NANQAFSEIS GIITMYYVVR ALSPYTEYEF YVIAVNNIGR
400
401
GPPSAPATCT TGETKMESAP RNVQVRTLSS STMVITWEPP ETPNGQVTGY
450
451
KVYYTTNSNQ PEASWNSQMV DNSELTTVSE LTPHAIYTVR VQAYTSMGAG
500
501
PMSTPVQVKA QQGVPSQPSN FRATDIGETA VTLQWTKPTH SSENIVHYEL
550
551
YWNDTYANQA HHKRISNSEA YTLDGLYPDT LYYIWLAARS QRGEGATTPP
600
601
IPVRTKQYVP GAPPRNITAI ATSSTTISLS WLPPPVERSN GRIIYYKVFF
650
651
VEVGREDDEA TTMTLNMTSI VLDELKRWTE YKIWVLAGTS VGDGPRSHPI
700
701
ILRTQEDVPG DPQDVKATPL NSTSIHVSWK PPLEKDRNGI IRGYHIHAQE
750
751
LRDEGKGFLN EPFKFDVVDT LEFNVTGLQP DTKYSIQVAA LTRKGDGDRS
800
801
AAIVVKTPGG VPVRPTVSLK IMEREPIVSI ELEWERPAQT YGELRGYRLR
850
851
WGVKDQALKE EMLSGPQMTK KRFDNLERGV EYEFRVAGSN HIGIGQETVK
900
901
IFQTPEGTPG GPPSNITIRF QTPDVLCVTW DPPTREHRNG IITRYDVQFH
950
951
KKIDHGLGSE RNMTLRKAVF TNLEENTEYI FRVRAYTKQG AGPFSDKLIV
1000
1001
ETERDMGRAP MSLQAEATSE QTAEIWWEPV TSRGKLLGYK IFYTMTAVED
1050
1051
LDDWQTKTVG LTESADLVNL EKFAQYAVAI AARFKNGLGR LSEKVTVRIK
1100
1101
PEDVPLNLRA HDVSTHSMTL SWSPPIRLTP VNYKISFDAM KVFVDSQGFS
1150
1151
QTQIVPKREI ILKHYVKTHT INELSPFTTY NVNVSAIPSD YSYRPPTKIT
1200
1201
VTTQMAAPQP MVKPDFYGVV NGEEILVILP QASEEYGPIS HYYLVVVPED
1250
1251
KSNLHKIPDQ FLTDDLLPGR NKPERPNAPY IAAKFPQRSI PFTFHLGSGD
1300
1301
DYHNFTNRKL EREKRYRIFV RAVVDTPQKH LYTSSPFSEF LSLDMREAPP
1350
1351
GERPHRPDPN WPAEPEVSVN RNKDEPEILW VVLPLMVSTF IVSTALIVLC
1400
1401
VVKRRRQPCK TPDQAAVTRP LMAADLGAGP TPSDPVDMRR LNFQTPGMIS
1450
1451
HPPIPISEFA NHIERLKSND NQKFSQEYES IEPGQQFTWD NSNLEHNKSK
1500
1501
NRYANVTAYD HSRVQLPAVE GVVGSDYINA NYCDGYRKHN AYVATQGPLQ
1550
1551
ETFVDFWRMC WELKTATIVM MTRLEERTRI KCDQYWPTRG TETYGQIFVT
1600
1601
ITETQELATY SIRTFQLCRQ GFNDRREIKQ LQFTAWPDHG VPDHPAPFLQ
1650
1651
FLRRCRALTP PESGPVIVHC SAGVGRTGCY IVIDSMLERM KHEKIIDIYG
1700
1701
HVTCLRAQRN YMVQTEDQYI FIHDAILEAI ICGVTEVPAR NLHTHLQKLL
1750
1751
ITEPGETISG MEVEFKKLSN VKMDSSKFVT ANLPCNKHKN RLVHILPYES
1800
1801
SRVYLTPIHG IEGSDYVNAS FIDGYRYRSA YIAAQGPVQD AAEDFWRMLW
1850
1851
EHNSTIVVML TKLKEMGREK CFQYWPHERS VRYQYYVVDP IAEYNMPQYK
1900
1901
LREFKVTDAR DGSSRTVRQF QFIDWPEQGV PKSGEGFIDF IGQVHKTKEQ
1950
1951
FGQDGPITVH CSAGVGRSGV FITLSIVLER MQYEGVLDVF QTVRILRSQR
2000
2001
PAMVQTEDQY HFCYRAALEY LGSFDNYTN                       
2029
 

Show the unformatted sequence.

Checksums:
CRC64:DF1F676A94050F2B
MD5:84c05cf586942a45f5807414d8f75702

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
I-set 140 - 227 2YD1 A 140 - 227 Jmol AstexViewer SPICE
3PXJ A 140 - 227 Jmol AstexViewer SPICE
B 140 - 227 Jmol AstexViewer SPICE
C 140 - 227 Jmol AstexViewer SPICE
D 140 - 227 Jmol AstexViewer SPICE
36 - 129 2YD1 A 36 - 129 Jmol AstexViewer SPICE
3PXJ A 36 - 129 Jmol AstexViewer SPICE
B 36 - 129 Jmol AstexViewer SPICE
C 36 - 129 Jmol AstexViewer SPICE
D 36 - 129 Jmol AstexViewer SPICE