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118  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTN1_HUMAN (P18031)

Summary

This is the summary of UniProt entry PTN1_HUMAN (P18031).

Description: Tyrosine-protein phosphatase non-receptor type 1 EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 435 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 3 4
Pfam A Y_phosphatase 40 276
disorder n/a 291 321
low_complexity n/a 299 320
disorder n/a 328 330
disorder n/a 338 352
disorder n/a 355 363
disorder n/a 365 367
disorder n/a 370 398
Pfam B Pfam-B_20538 371 433
transmembrane n/a 409 430

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P18031. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS
50
51
PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW
100
101
EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK
150
151
SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE
200
201
SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL
250
251
LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE
300
301
PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK
350
351
GSPLNAAPYG IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED
400
401
HALSYWKPFL VNMCVATVLT AGAYLCYRFL FNSNT                
435
 

Show the unformatted sequence.

Checksums:
CRC64:802377DCD33F41FD
MD5:d750635190b881751ca92080a6bf24fe

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Y_phosphatase 40 - 276 1A5Y A 40 - 276 Jmol AstexViewer SPICE
1AAX A 40 - 276 Jmol AstexViewer SPICE
1BZC A 40 - 276 Jmol AstexViewer SPICE
1BZH A 40 - 276 Jmol AstexViewer SPICE
1BZJ A 40 - 276 Jmol AstexViewer SPICE
1C83 A 40 - 276 Jmol AstexViewer SPICE
1C84 A 40 - 276 Jmol AstexViewer SPICE
1C85 A 40 - 276 Jmol AstexViewer SPICE
1C86 A 40 - 276 Jmol AstexViewer SPICE
1C87 A 40 - 276 Jmol AstexViewer SPICE
1C88 A 40 - 276 Jmol AstexViewer SPICE
1ECV A 40 - 276 Jmol AstexViewer SPICE
1EEN A 40 - 276 Jmol AstexViewer SPICE
1EEO A 40 - 276 Jmol AstexViewer SPICE
1G1F A 40 - 276 Jmol AstexViewer SPICE
1G1G A 40 - 276 Jmol AstexViewer SPICE
1G1H A 40 - 276 Jmol AstexViewer SPICE
1G7F A 40 - 276 Jmol AstexViewer SPICE
1G7G A 40 - 276 Jmol AstexViewer SPICE
1GFY A 40 - 276 Jmol AstexViewer SPICE
1I57 A 40 - 276 Jmol AstexViewer SPICE
1JF7 A 40 - 276 Jmol AstexViewer SPICE
B 40 - 276 Jmol AstexViewer SPICE
1KAK A 40 - 276 Jmol AstexViewer SPICE
1KAV A 40 - 276 Jmol AstexViewer SPICE
1L8G A 40 - 276 Jmol AstexViewer SPICE
1LQF A 540 - 776 Jmol AstexViewer SPICE
B 540 - 776 Jmol AstexViewer SPICE
C 540 - 776 Jmol AstexViewer SPICE
D 540 - 776 Jmol AstexViewer SPICE
1NL9 A 40 - 276 Jmol AstexViewer SPICE
1NNY A 40 - 276 Jmol AstexViewer SPICE
1NO6 A 40 - 276 Jmol AstexViewer SPICE
1NWE A 40 - 276 Jmol AstexViewer SPICE
1NWL A 40 - 276 Jmol AstexViewer SPICE
1NZ7 A 40 - 276 Jmol AstexViewer SPICE
1OEM X 40 - 276 Jmol AstexViewer SPICE
1OEO X 40 - 276 Jmol AstexViewer SPICE
1OES A 40 - 276 Jmol AstexViewer SPICE
1OET A 40 - 276 Jmol AstexViewer SPICE
1OEU A 40 - 276 Jmol AstexViewer SPICE
1OEV A 40 - 276 Jmol AstexViewer SPICE
1ONY A 40 - 276 Jmol AstexViewer SPICE
1ONZ A 40 - 276 Jmol AstexViewer SPICE
1PA1 A 540 - 776 Jmol AstexViewer SPICE
1PH0 A 40 - 276 Jmol AstexViewer SPICE
1PTT A 40 - 276 Jmol AstexViewer SPICE
1PTU A 40 - 276 Jmol AstexViewer SPICE
1PTV A 40 - 276 Jmol AstexViewer SPICE
1PTY A 40 - 276 Jmol AstexViewer SPICE
1PXH A 40 - 276 Jmol AstexViewer SPICE
1PYN A 40 - 276 Jmol AstexViewer SPICE
1Q1M A 40 - 276 Jmol AstexViewer SPICE
1Q6J A 40 - 276 Jmol AstexViewer SPICE
1Q6M A 40 - 276 Jmol AstexViewer SPICE
1Q6N A 540 - 776 Jmol AstexViewer SPICE
B 1040 - 1276 Jmol AstexViewer SPICE
1Q6P A 540 - 776 Jmol AstexViewer SPICE
B 1040 - 1276 Jmol AstexViewer SPICE
1Q6S A 540 - 776 Jmol AstexViewer SPICE
B 1040 - 1276 Jmol AstexViewer SPICE
1Q6T A 540 - 776 Jmol AstexViewer SPICE
B 1040 - 1276 Jmol AstexViewer SPICE
1QXK A 40 - 276 Jmol AstexViewer SPICE
1SUG A 40 - 276 Jmol AstexViewer SPICE
1T48 A 40 - 276 Jmol AstexViewer SPICE
1T49 A 40 - 276 Jmol AstexViewer SPICE
1T4J A 40 - 276 Jmol AstexViewer SPICE
1WAX A 40 - 276 Jmol AstexViewer SPICE
1XBO A 40 - 276 Jmol AstexViewer SPICE
2AZR A 40 - 276 Jmol AstexViewer SPICE
2B07 A 40 - 276 Jmol AstexViewer SPICE
2B4S A 40 - 276 Jmol AstexViewer SPICE
C 40 - 276 Jmol AstexViewer SPICE
2BGD A 40 - 276 Jmol AstexViewer SPICE
2BGE A 40 - 276 Jmol AstexViewer SPICE
2CM2 A 40 - 276 Jmol AstexViewer SPICE
2CM3 A 40 - 276 Jmol AstexViewer SPICE
B 40 - 276 Jmol AstexViewer SPICE
2CM7 A 40 - 276 Jmol AstexViewer SPICE
2CM8 A 40 - 276 Jmol AstexViewer SPICE
2CMA A 40 - 276 Jmol AstexViewer SPICE
2CMB A 40 - 276 Jmol AstexViewer SPICE
2CMC A 40 - 276 Jmol AstexViewer SPICE
2CNE A 40 - 276 Jmol AstexViewer SPICE
2CNF A 40 - 276 Jmol AstexViewer SPICE
2CNG A 40 - 276 Jmol AstexViewer SPICE
2CNH A 40 - 276 Jmol AstexViewer SPICE
2CNI A 40 - 276 Jmol AstexViewer SPICE
2F6F A 40 - 276 Jmol AstexViewer SPICE
2F6T A 40 - 276 Jmol AstexViewer SPICE
2F6V A 40 - 276 Jmol AstexViewer SPICE
2F6W A 40 - 276 Jmol AstexViewer SPICE
2F6Y A 40 - 276 Jmol AstexViewer SPICE
2F6Z A 40 - 276 Jmol AstexViewer SPICE
2F70 A 40 - 276 Jmol AstexViewer SPICE
2F71 A 40 - 276 Jmol AstexViewer SPICE
2FJM A 540 - 776 Jmol AstexViewer SPICE
B 540 - 776 Jmol AstexViewer SPICE
2FJN A 540 - 776 Jmol AstexViewer SPICE
B 540 - 776 Jmol AstexViewer SPICE
2H4G A 40 - 276 Jmol AstexViewer SPICE
2H4K A 40 - 276 Jmol AstexViewer SPICE
2HB1 A 40 - 276 Jmol AstexViewer SPICE
2HNP A 40 - 276 Jmol AstexViewer SPICE
2HNQ A 40 - 276 Jmol AstexViewer SPICE
2NT7 A 40 - 276 Jmol AstexViewer SPICE
2NTA A 40 - 276 Jmol AstexViewer SPICE
2QBP A 40 - 276 Jmol AstexViewer SPICE
2QBQ A 40 - 276 Jmol AstexViewer SPICE
2QBR A 40 - 276 Jmol AstexViewer SPICE
2QBS A 40 - 276 Jmol AstexViewer SPICE
2VEU A 40 - 276 Jmol AstexViewer SPICE
2VEV A 40 - 276 Jmol AstexViewer SPICE
2VEW A 40 - 276 Jmol AstexViewer SPICE
2VEX A 40 - 276 Jmol AstexViewer SPICE
2VEY A 40 - 276 Jmol AstexViewer SPICE
2ZMM A 40 - 276 Jmol AstexViewer SPICE
2ZN7 A 40 - 276 Jmol AstexViewer SPICE
3A5J A 40 - 276 Jmol AstexViewer SPICE
3A5K A 40 - 276 Jmol AstexViewer SPICE
3CWE A 540 - 776 Jmol AstexViewer SPICE
3D9C A 40 - 276 Jmol AstexViewer SPICE
3EAX A 40 - 276 Jmol AstexViewer SPICE
3EB1 A 40 - 276 Jmol AstexViewer SPICE
3EU0 A 40 - 276 Jmol AstexViewer SPICE
3I7Z A 40 - 276 Jmol AstexViewer SPICE
3I80 A 40 - 276 Jmol AstexViewer SPICE
3SME A 40 - 276 Jmol AstexViewer SPICE
3ZV2 A 40 - 276 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.