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17  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: VINC_HUMAN (P18206)

Summary

This is the summary of UniProt entry VINC_HUMAN (P18206).

Description: Vinculin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1134 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Vinculin 3 485
disorder n/a 65 66
disorder n/a 175 177
disorder n/a 224 225
disorder n/a 270 271
disorder n/a 281 291
disorder n/a 294 300
disorder n/a 336 355
coiled_coil n/a 360 387
disorder n/a 371 372
disorder n/a 374 376
disorder n/a 378 379
disorder n/a 381 382
disorder n/a 387 410
disorder n/a 446 468
disorder n/a 473 492
Pfam A Vinculin 481 921
disorder n/a 501 502
disorder n/a 504 508
disorder n/a 515 517
low_complexity n/a 549 560
disorder n/a 556 578
coiled_coil n/a 573 593
disorder n/a 582 587
disorder n/a 591 597
disorder n/a 609 614
disorder n/a 617 634
disorder n/a 636 638
low_complexity n/a 638 655
disorder n/a 641 649
disorder n/a 651 653
disorder n/a 661 664
disorder n/a 694 696
disorder n/a 776 787
disorder n/a 790 792
disorder n/a 794 796
disorder n/a 798 806
disorder n/a 809 810
disorder n/a 829 830
disorder n/a 833 917
low_complexity n/a 835 852
low_complexity n/a 860 887
low_complexity n/a 917 943
Pfam A Vinculin 918 1134
disorder n/a 923 927
disorder n/a 932 958
disorder n/a 960 961
disorder n/a 964 971
disorder n/a 973 975
disorder n/a 1077 1080
disorder n/a 1085 1087
disorder n/a 1090 1091
coiled_coil n/a 1092 1112

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P18206. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA
50
51
VSNLVRVGKE TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY
100
101
SVPARDYLID GSRGILSGTS DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV
150
151
VETMEDLVTY TKNLGPGMTK MAKMIDERQQ ELTHQEHRVM LVNSMNTVKE
200
201
LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE INEIIRVLQL
250
251
TSWDEDAWAS KDTEAMKRAL ASIDSKLNQA KGWLRDPSAS PGDAGEQAIR
300
301
QILDEAGKVG ELCAGKERRE ILGTCKMLGQ MTDQVADLRA RGQGSSPVAM
350
351
QKAQQVSQGL DVLTAKVENA ARKLEAMTNS KQSIAKKIDA AQNWLADPNG
400
401
GPEGEEQIRG ALAEARKIAE LCDDPKERDD ILRSLGEISA LTSKLADLRR
450
451
QGKGDSPEAR ALAKQVATAL QNLQTKTNRA VANSRPAKAA VHLEGKIEQA
500
501
QRWIDNPTVD DRGVGQAAIR GLVAEGHRLA NVMMGPYRQD LLAKCDRVDQ
550
551
LTAQLADLAA RGEGESPQAR ALASQLQDSL KDLKARMQEA MTQEVSDVFS
600
601
DTTTPIKLLA VAATAPPDAP NREEVFDERA ANFENHSGKL GATAEKAAAV
650
651
GTANKSTVEG IQASVKTARE LTPQVVSAAR ILLRNPGNQA AYEHFETMKN
700
701
QWIDNVEKMT GLVDEAIDTK SLLDASEEAI KKDLDKCKVA MANIQPQMLV
750
751
AGATSIARRA NRILLVAKRE VENSEDPKFR EAVKAASDEL SKTISPMVMD
800
801
AKAVAGNISD PGLQKSFLDS GYRILGAVAK VREAFQPQEP DFPPPPPDLE
850
851
QLRLTDELAP PKPPLPEGEV PPPRPPPPEE KDEEFPEQKA GEVINQPMMM
900
901
AARQLHDEAR KWSSKPGIPA AEVGIGVVAE ADAADAAGFP VPPDMEDDYE
950
951
PELLLMPSNQ PVNQPILAAA QSLHREATKW SSKGNDIIAA AKRMALLMAE
1000
1001
MSRLVRGGSG TKRALIQCAK DIAKASDEVT RLAKEVAKQC TDKRIRTNLL
1050
1051
QVCERIPTIS TQLKILSTVK ATMLGRTNIS DEESEQATEM LVHNAQNLMQ
1100
1101
SVKETVREAE AASIKIRTDA GFTLRWVRKT PWYQ                 
1134
 

Show the unformatted sequence.

Checksums:
CRC64:BFBD687DA836B0FA
MD5:b2385af45cf68a62681c6fe17d3e8c6d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Vinculin 3 - 250 3S90 A 3 - 250 Jmol AstexViewer SPICE
3 - 252 3S90 B 3 - 252 Jmol AstexViewer SPICE
4EHP A 3 - 252 Jmol AstexViewer SPICE
3 - 254 4DJ9 A 3 - 254 Jmol AstexViewer SPICE
3 - 255 3TJ5 A 3 - 255 Jmol AstexViewer SPICE
3 - 257 2GWW A 3 - 257 Jmol AstexViewer SPICE
2HSQ A 3 - 257 Jmol AstexViewer SPICE
3TJ6 A 3 - 257 Jmol AstexViewer SPICE
3 - 258 1RKC A 3 - 258 Jmol AstexViewer SPICE
1RKE A 3 - 258 Jmol AstexViewer SPICE
1SYQ A 3 - 258 Jmol AstexViewer SPICE
1YDI A 3 - 258 Jmol AstexViewer SPICE
2IBF A 3 - 258 Jmol AstexViewer SPICE
3RF3 A 3 - 258 Jmol AstexViewer SPICE
B 3 - 258 Jmol AstexViewer SPICE
3 - 485 1TR2 A 3 - 485 Jmol AstexViewer SPICE
B 3 - 485 Jmol AstexViewer SPICE
481 - 910 1TR2 A 481 - 910 Jmol AstexViewer SPICE
B 481 - 910 Jmol AstexViewer SPICE
882 - 904 1RKE B 882 - 904 Jmol AstexViewer SPICE
3H2U A 882 - 904 Jmol AstexViewer SPICE
883 - 904 3H2U C 883 - 904 Jmol AstexViewer SPICE
884 - 904 3H2V A 884 - 904 Jmol AstexViewer SPICE
B 884 - 904 Jmol AstexViewer SPICE
C 884 - 904 Jmol AstexViewer SPICE
D 884 - 904 Jmol AstexViewer SPICE
961 - 1129 3MYI A 961 - 1129 Jmol AstexViewer SPICE
973 - 1129 3H2V A 905 - 1061 Jmol AstexViewer SPICE
973 - 1131 1RKE B 905 - 1063 Jmol AstexViewer SPICE
3H2U A 905 - 1063 Jmol AstexViewer SPICE
C 905 - 1063 Jmol AstexViewer SPICE
3H2V B 905 - 1063 Jmol AstexViewer SPICE
C 905 - 1063 Jmol AstexViewer SPICE
D 905 - 1063 Jmol AstexViewer SPICE
979 - 1129 1TR2 A 911 - 1061 Jmol AstexViewer SPICE
979 - 1130 1TR2 B 911 - 1062 Jmol AstexViewer SPICE