Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: TNR1B_HUMAN (P20333)

Summary

This is the summary of UniProt entry TNR1B_HUMAN (P20333).

Description: Tumor necrosis factor receptor superfamily member 1B
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 461 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 22
Pfam A TNFR_c6 40 75
Pfam A TNFR_c6 78 118
Pfam B Pfam-B_295 153 204
disorder n/a 201 202
disorder n/a 210 257
low_complexity n/a 227 240
transmembrane n/a 258 283
disorder n/a 294 379
low_complexity n/a 325 338
disorder n/a 381 382
low_complexity n/a 388 403
disorder n/a 394 461

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P20333. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA
50
51
QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC
100
101
SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA
150
151
RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC
200
201
TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS FLLPMGPSPP
250
251
AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV
300
301
PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA
350
351
PGVEASGAGE ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ
400
401
ASSTMGDTDS SPSESPKDEQ VPFSKEECAF RSQLETPETL LGSTEEKPLP
450
451
LGVPDAGMKP S                                          
461
 

Show the unformatted sequence.

Checksums:
CRC64:603D0AE1CD69ACBF
MD5:4127b3aecbc06673a350274fe6615fe5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TNFR_c6 40 - 75 3ALQ R 18 - 53 Jmol AstexViewer SPICE
S 18 - 53 Jmol AstexViewer SPICE
T 18 - 53 Jmol AstexViewer SPICE
U 18 - 53 Jmol AstexViewer SPICE
V 18 - 53 Jmol AstexViewer SPICE
W 18 - 53 Jmol AstexViewer SPICE
78 - 118 3ALQ R 56 - 96 Jmol AstexViewer SPICE
S 56 - 96 Jmol AstexViewer SPICE
T 56 - 96 Jmol AstexViewer SPICE
U 56 - 96 Jmol AstexViewer SPICE
V 56 - 96 Jmol AstexViewer SPICE
W 56 - 96 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.