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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCF_HUMAN (P21583)

Summary

This is the summary of UniProt entry SCF_HUMAN (P21583).

Description: Kit ligand
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 273 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A SCF 1 273
sig_p n/a 1 25
low_complexity n/a 191 202
disorder n/a 195 208
transmembrane n/a 213 237
disorder n/a 247 251
low_complexity n/a 249 260
coiled_coil n/a 253 273
disorder n/a 255 267

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P21583. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD
50
51
YMITLKYVPG MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI
100
101
IDKLVNIVDD LVECVKENSS KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA
150
151
FKDFVVASET SDCVVSSTLS PEKDSRVSVT KPFMLPPVAA SSLRNDSSSS
200
201
NRKAKNPPGD SSLHWAAMAL PALFSLIIGF AFGALYWKKR QPSLTRAVEN
250
251
IQINEEDNEI SMLQEKEREF QEV                             
273
 

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Checksums:
CRC64:19FD362CB59C6607
MD5:2f9759f9468e093934f80b3176a4621e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SCF 27 - 165 2E9W C 2 - 140 Jmol AstexViewer SPICE
27 - 166 1EXZ B 202 - 341 Jmol AstexViewer SPICE
28 - 155 2E9W D 3 - 130 Jmol AstexViewer SPICE
29 - 164 1EXZ A 4 - 139 Jmol AstexViewer SPICE
34 - 157 1EXZ D 609 - 732 Jmol AstexViewer SPICE
34 - 164 1EXZ C 409 - 539 Jmol AstexViewer SPICE
36 - 151 1SCF C 11 - 126 Jmol AstexViewer SPICE
36 - 152 1SCF D 11 - 127 Jmol AstexViewer SPICE
36 - 163 1SCF B 11 - 138 Jmol AstexViewer SPICE
36 - 166 1SCF A 11 - 141 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.