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20  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CBL_HUMAN (P22681)

Summary

This is the summary of UniProt entry CBL_HUMAN (P22681).

Description: E3 ubiquitin-protein ligase CBL EC=6.3.2.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 906 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 21
low_complexity n/a 8 24
disorder n/a 28 31
disorder n/a 35 50
low_complexity n/a 35 48
Pfam A Cbl_N 47 176
Pfam A Cbl_N2 178 262
Pfam A Cbl_N3 264 349
disorder n/a 349 351
disorder n/a 355 356
Pfam A zf-C3HC4 381 419
disorder n/a 434 476
low_complexity n/a 456 465
disorder n/a 478 667
low_complexity n/a 493 504
Pfam B Pfam-B_30089 506 568
low_complexity n/a 532 551
disorder n/a 670 719
disorder n/a 733 735
disorder n/a 737 738
disorder n/a 740 790
disorder n/a 801 802
disorder n/a 804 859
low_complexity n/a 837 859
Pfam A UBA 857 892
disorder n/a 861 862
disorder n/a 864 865
coiled_coil n/a 871 891

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P22681. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGNVKKSSG AGGGSGSGGS GSGGLIGLMK DAFQPHHHHH HHLSPHPPGT
50
51
VDKKMVEKCW KLMDKVVRLC QNPKLALKNS PPYILDLLPD TYQHLRTILS
100
101
RYEGKMETLG ENEYFRVFME NLMKKTKQTI SLFKEGKERM YEENSQPRRN
150
151
LTKLSLIFSH MLAELKGIFP SGLFQGDTFR ITKADAAEFW RKAFGEKTIV
200
201
PWKSFRQALH EVHPISSGLE AMALKSTIDL TCNDYISVFE FDIFTRLFQP
250
251
WSSLLRNWNS LAVTHPGYMA FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL
300
301
GQWAIGYVTA DGNILQTIPH NKPLFQALID GFREGFYLFP DGRNQNPDLT
350
351
GLCEPTPQDH IKVTQEQYEL YCEMGSTFQL CKICAENDKD VKIEPCGHLM
400
401
CTSCLTSWQE SEGQGCPFCR CEIKGTEPIV VDPFDPRGSG SLLRQGAEGA
450
451
PSPNYDDDDD ERADDTLFMM KELAGAKVER PPSPFSMAPQ ASLPPVPPRL
500
501
DLLPQRVCVP SSASALGTAS KAASGSLHKD KPLPVPPTLR DLPPPPPPDR
550
551
PYSVGAESRP QRRPLPCTPG DCPSRDKLPP VPSSRLGDSW LPRPIPKVPV
600
601
SAPSSSDPWT GRELTNRHSL PFSLPSQMEP RPDVPRLGST FSLDTSMSMN
650
651
SSPLVGPECD HPKIKPSSSA NAIYSLAARP LPVPKLPPGE QCEGEEDTEY
700
701
MTPSSRPLRP LDTSQSSRAC DCDQQIDSCT YEAMYNIQSQ APSITESSTF
750
751
GEGNLAAAHA NTGPEESENE DDGYDVPKPP VPAVLARRTL SDISNASSSF
800
801
GWLSLDGDPT TNVTEGSQVP ERPPKPFPRR INSERKAGSC QQGSGPAASA
850
851
ATASPQLSSE IENLMSQGYS YQDIQKALVI AQNNIEMAKN ILREFVSISS
900
901
PAHVAT                                                
906
 

Show the unformatted sequence.

Checksums:
CRC64:1AA6BF67377322CA
MD5:c615e733e9af5b2c2cda9b0a3e197b05

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cbl_N 47 - 176 1B47 A 47 - 176 Jmol AstexViewer SPICE
B 47 - 176 Jmol AstexViewer SPICE
C 47 - 176 Jmol AstexViewer SPICE
1FBV A 47 - 176 Jmol AstexViewer SPICE
2CBL A 47 - 176 Jmol AstexViewer SPICE
2Y1M A 47 - 176 Jmol AstexViewer SPICE
B 47 - 176 Jmol AstexViewer SPICE
C 47 - 176 Jmol AstexViewer SPICE
D 47 - 176 Jmol AstexViewer SPICE
E 47 - 176 Jmol AstexViewer SPICE
F 47 - 176 Jmol AstexViewer SPICE
3BUW B 47 - 176 Jmol AstexViewer SPICE
D 47 - 176 Jmol AstexViewer SPICE
3BUX B 47 - 176 Jmol AstexViewer SPICE
D 47 - 176 Jmol AstexViewer SPICE
48 - 176 1YVH A 48 - 176 Jmol AstexViewer SPICE
3BUM B 48 - 176 Jmol AstexViewer SPICE
3BUN B 48 - 176 Jmol AstexViewer SPICE
3BUO B 48 - 176 Jmol AstexViewer SPICE
D 48 - 176 Jmol AstexViewer SPICE
4A4B A 48 - 176 Jmol AstexViewer SPICE
4A4C A 48 - 176 Jmol AstexViewer SPICE
49 - 176 3PLF B 49 - 176 Jmol AstexViewer SPICE
D 49 - 176 Jmol AstexViewer SPICE
52 - 176 2Y1N A 52 - 176 Jmol AstexViewer SPICE
C 52 - 176 Jmol AstexViewer SPICE
55 - 176 3OB1 B 55 - 176 Jmol AstexViewer SPICE
3OB2 B 55 - 176 Jmol AstexViewer SPICE
Cbl_N2 178 - 262 1B47 A 178 - 262 Jmol AstexViewer SPICE
B 178 - 262 Jmol AstexViewer SPICE
C 178 - 262 Jmol AstexViewer SPICE
1FBV A 178 - 262 Jmol AstexViewer SPICE
1YVH A 178 - 262 Jmol AstexViewer SPICE
2CBL A 178 - 262 Jmol AstexViewer SPICE
2Y1M A 178 - 262 Jmol AstexViewer SPICE
B 178 - 262 Jmol AstexViewer SPICE
C 178 - 262 Jmol AstexViewer SPICE
D 178 - 262 Jmol AstexViewer SPICE
E 178 - 262 Jmol AstexViewer SPICE
F 178 - 262 Jmol AstexViewer SPICE
2Y1N A 178 - 262 Jmol AstexViewer SPICE
C 178 - 262 Jmol AstexViewer SPICE
3BUM B 178 - 262 Jmol AstexViewer SPICE
3BUN B 178 - 262 Jmol AstexViewer SPICE
3BUO B 178 - 262 Jmol AstexViewer SPICE
D 178 - 262 Jmol AstexViewer SPICE
3BUW B 178 - 262 Jmol AstexViewer SPICE
D 178 - 262 Jmol AstexViewer SPICE
3BUX B 178 - 262 Jmol AstexViewer SPICE
D 178 - 262 Jmol AstexViewer SPICE
3OB1 B 178 - 262 Jmol AstexViewer SPICE
3OB2 B 178 - 262 Jmol AstexViewer SPICE
3PLF B 178 - 262 Jmol AstexViewer SPICE
D 178 - 262 Jmol AstexViewer SPICE
4A4B A 178 - 262 Jmol AstexViewer SPICE
4A4C A 178 - 262 Jmol AstexViewer SPICE
Cbl_N3 264 - 349 1B47 A 264 - 349 Jmol AstexViewer SPICE
B 264 - 349 Jmol AstexViewer SPICE
C 264 - 349 Jmol AstexViewer SPICE
1FBV A 264 - 349 Jmol AstexViewer SPICE
1YVH A 264 - 349 Jmol AstexViewer SPICE
2CBL A 264 - 349 Jmol AstexViewer SPICE
2Y1M A 264 - 349 Jmol AstexViewer SPICE
B 264 - 349 Jmol AstexViewer SPICE
C 264 - 349 Jmol AstexViewer SPICE
D 264 - 349 Jmol AstexViewer SPICE
E 264 - 349 Jmol AstexViewer SPICE
F 264 - 349 Jmol AstexViewer SPICE
2Y1N A 264 - 349 Jmol AstexViewer SPICE
C 264 - 349 Jmol AstexViewer SPICE
3BUM B 264 - 349 Jmol AstexViewer SPICE
3BUN B 264 - 349 Jmol AstexViewer SPICE
3BUO B 264 - 349 Jmol AstexViewer SPICE
D 264 - 349 Jmol AstexViewer SPICE
3BUW B 264 - 349 Jmol AstexViewer SPICE
D 264 - 349 Jmol AstexViewer SPICE
3BUX B 264 - 349 Jmol AstexViewer SPICE
D 264 - 349 Jmol AstexViewer SPICE
3OB1 B 264 - 349 Jmol AstexViewer SPICE
3OB2 B 264 - 349 Jmol AstexViewer SPICE
3PLF B 264 - 349 Jmol AstexViewer SPICE
D 264 - 349 Jmol AstexViewer SPICE
4A4B A 264 - 349 Jmol AstexViewer SPICE
4A4C A 264 - 349 Jmol AstexViewer SPICE
UBA 857 - 892 2JUJ A 7 - 42 Jmol AstexViewer SPICE
2OO9 A 857 - 892 Jmol AstexViewer SPICE
B 857 - 892 Jmol AstexViewer SPICE
858 - 892 2OO9 C 858 - 892 Jmol AstexViewer SPICE
zf-C3HC4 381 - 419 1FBV A 381 - 419 Jmol AstexViewer SPICE
2K4D A 381 - 419 Jmol AstexViewer SPICE
2Y1M A 381 - 419 Jmol AstexViewer SPICE
B 381 - 419 Jmol AstexViewer SPICE
C 381 - 419 Jmol AstexViewer SPICE
D 381 - 419 Jmol AstexViewer SPICE
E 381 - 419 Jmol AstexViewer SPICE
F 381 - 419 Jmol AstexViewer SPICE
2Y1N A 381 - 419 Jmol AstexViewer SPICE
C 381 - 419 Jmol AstexViewer SPICE
4A49 A 381 - 419 Jmol AstexViewer SPICE
4A4B A 381 - 419 Jmol AstexViewer SPICE
4A4C A 381 - 419 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.