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23  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: COMT_RAT (P22734)

Summary

This is the summary of UniProt entry COMT_RAT (P22734).

Description: Catechol O-methyltransferase EC=2.1.1.6
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
View Pfam proteome data.
Length: 264 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 25
low_complexity n/a 3 26
Pfam A Methyltransf_3 62 224

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P22734. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLAAVSLGL LLLALLLLLR HLGWGLVTIF WFEYVLQPVH NLIMGDTKEQ
50
51
RILRYVQQNA KPGDPQSVLE AIDTYCTQKE WAMNVGDAKG QIMDAVIREY
100
101
SPSLVLELGA YCGYSAVRMA RLLQPGARLL TMEMNPDYAA ITQQMLNFAG
150
151
LQDKVTILNG ASQDLIPQLK KKYDVDTLDM VFLDHWKDRY LPDTLLLEKC
200
201
GLLRKGTVLL ADNVIVPGTP DFLAYVRGSS SFECTHYSSY LEYMKVVDGL
250
251
EKAIYQGPSS PDKS                                       
264
 

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Checksums:
CRC64:F535DFF49C062854
MD5:f378c4a1ccfceaf3d2d736d5a0247444

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Methyltransf_3 62 - 224 1H1D A 19 - 181 Jmol AstexViewer SPICE
1JR4 A 19 - 181 Jmol AstexViewer SPICE
1VID A 19 - 181 Jmol AstexViewer SPICE
2CL5 A 19 - 181 Jmol AstexViewer SPICE
B 19 - 181 Jmol AstexViewer SPICE
2ZLB A 19 - 181 Jmol AstexViewer SPICE
2ZTH A 19 - 181 Jmol AstexViewer SPICE
2ZVJ A 19 - 181 Jmol AstexViewer SPICE
3A7D A 19 - 181 Jmol AstexViewer SPICE
3HVH A 62 - 224 Jmol AstexViewer SPICE
3HVI A 62 - 224 Jmol AstexViewer SPICE
3HVJ A 62 - 224 Jmol AstexViewer SPICE
B 62 - 224 Jmol AstexViewer SPICE
3HVK A 62 - 224 Jmol AstexViewer SPICE
3NW9 A 19 - 181 Jmol AstexViewer SPICE
3NWB A 19 - 181 Jmol AstexViewer SPICE
3NWE A 19 - 181 Jmol AstexViewer SPICE
3OE4 A 19 - 181 Jmol AstexViewer SPICE
3OE5 A 19 - 181 Jmol AstexViewer SPICE
3OZR A 19 - 181 Jmol AstexViewer SPICE
3OZS A 19 - 181 Jmol AstexViewer SPICE
3OZT A 19 - 181 Jmol AstexViewer SPICE
3R6T A 62 - 224 Jmol AstexViewer SPICE
3S68 A 19 - 181 Jmol AstexViewer SPICE
3U81 A 19 - 181 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.