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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CAH4_HUMAN (P22748)

Summary

This is the summary of UniProt entry CAH4_HUMAN (P22748).

Description: Carbonic anhydrase 4 EC=4.2.1.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 312 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 19
low_complexity n/a 4 21
Pfam A Carb_anhydrase 23 285
disorder n/a 53 55
disorder n/a 57 58
disorder n/a 146 156
disorder n/a 191 192
disorder n/a 201 202
low_complexity n/a 285 309
transmembrane n/a 293 311

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P22748. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRMLLALLAL SAARPSASAE SHWCYEVQAE SSNYPCLVPV KWGGNCQKDR
50
51
QSPINIVTTK AKVDKKLGRF FFSGYDKKQT WTVQNNGHSV MMLLENKASI
100
101
SGGGLPAPYQ AKQLHLHWSD LPYKGSEHSL DGEHFAMEMH IVHEKEKGTS
150
151
RNVKEAQDPE DEIAVLAFLV EAGTQVNEGF QPLVEALSNI PKPEMSTTMA
200
201
ESSLLDLLPK EEKLRHYFRY LGSLTTPTCD EKVVWTVFRE PIQLHREQIL
250
251
AFSQKLYYDK EQTVSMKDNV RPLQQLGQRT VIKSGAPGRP LPWALPALLG
300
301
PMLACLLAGF LR                                         
312
 

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Checksums:
CRC64:EF5F182474ABE9B0
MD5:fa54b8425c9e867258d33389833c4613

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Carb_anhydrase 23 - 284 1ZNC A 5 - 259 Jmol AstexViewer SPICE
B 5 - 259 Jmol AstexViewer SPICE
3F7B A 5 - 259 Jmol AstexViewer SPICE
B 5 - 259 Jmol AstexViewer SPICE
3F7U A 5 - 259 Jmol AstexViewer SPICE
B 5 - 259 Jmol AstexViewer SPICE
C 5 - 259 Jmol AstexViewer SPICE
D 5 - 259 Jmol AstexViewer SPICE
3FW3 A 5 - 259 Jmol AstexViewer SPICE
B 5 - 259 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.