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23  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MMP8_HUMAN (P22894)

Summary

This is the summary of UniProt entry MMP8_HUMAN (P22894).

Description: Neutrophil collagenase EC=3.4.24.34
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 467 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 20
low_complexity n/a 4 13
Pfam A PG_binding_1 26 86
disorder n/a 83 88
disorder n/a 95 96
disorder n/a 98 99
Pfam A Peptidase_M10 107 262
disorder n/a 174 180
disorder n/a 193 197
disorder n/a 267 277
Pfam A Hemopexin 285 327
Pfam A Hemopexin 329 372
Pfam A Hemopexin 377 422

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P22894. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFSLKTLPFL LLLHVQISKA FPVSSKEKNT KTVQDYLEKF YQLPSNQYQS
50
51
TRKNGTNVIV EKLKEMQRFF GLNVTGKPNE ETLDMMKKPR CGVPDSGGFM
100
101
LTPGNPKWER TNLTYRIRNY TPQLSEAEVE RAIKDAFELW SVASPLIFTR
150
151
ISQGEADINI AFYQRDHGDN SPFDGPNGIL AHAFQPGQGI GGDAHFDAEE
200
201
TWTNTSANYN LFLVAAHEFG HSLGLAHSSD PGALMYPNYA FRETSNYSLP
250
251
QDDIDGIQAI YGLSSNPIQP TGPSTPKPCD PSLTFDAITT LRGEILFFKD
300
301
RYFWRRHPQL QRVEMNFISL FWPSLPTGIQ AAYEDFDRDL IFLFKGNQYW
350
351
ALSGYDILQG YPKDISNYGF PSSVQAIDAA VFYRSKTYFF VNDQFWRYDN
400
401
QRQFMEPGYP KSISGAFPGI ESKVDAVFQQ EHFFHVFSGP RYYAFDLIAQ
450
451
RVTRVARGNK WLNCRYG                                    
467
 

Show the unformatted sequence.

Checksums:
CRC64:4D4602A53AD7F8BC
MD5:9b1fa90a47b5a5572926013b922b7c5f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_M10 107 - 262 1A85 A 87 - 242 Jmol AstexViewer SPICE
1A86 A 87 - 242 Jmol AstexViewer SPICE
1BZS A 87 - 242 Jmol AstexViewer SPICE
1I73 A 87 - 242 Jmol AstexViewer SPICE
1I76 A 87 - 242 Jmol AstexViewer SPICE
1JAN A 87 - 242 Jmol AstexViewer SPICE
1JAO A 87 - 242 Jmol AstexViewer SPICE
1JAP A 87 - 242 Jmol AstexViewer SPICE
1JAQ A 87 - 242 Jmol AstexViewer SPICE
1JH1 A 87 - 242 Jmol AstexViewer SPICE
1JJ9 A 87 - 242 Jmol AstexViewer SPICE
1KBC A 87 - 242 Jmol AstexViewer SPICE
B 87 - 242 Jmol AstexViewer SPICE
1MMB A 87 - 242 Jmol AstexViewer SPICE
1MNC A 108 - 263 Jmol AstexViewer SPICE
1ZP5 A 87 - 242 Jmol AstexViewer SPICE
1ZS0 A 87 - 242 Jmol AstexViewer SPICE
1ZVX A 87 - 242 Jmol AstexViewer SPICE
2OY2 A 87 - 242 Jmol AstexViewer SPICE
F 87 - 242 Jmol AstexViewer SPICE
2OY4 A 87 - 242 Jmol AstexViewer SPICE
F 87 - 242 Jmol AstexViewer SPICE
3DNG A 87 - 242 Jmol AstexViewer SPICE
B 87 - 242 Jmol AstexViewer SPICE
3DPE A 87 - 242 Jmol AstexViewer SPICE
3DPF A 87 - 242 Jmol AstexViewer SPICE
B 87 - 242 Jmol AstexViewer SPICE
3TT4 A 87 - 242 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.