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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTPRB_HUMAN (P23467)

Summary

This is the summary of UniProt entry PTPRB_HUMAN (P23467).

Description: Receptor-type tyrosine-protein phosphatase beta EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1997 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 22
Pfam A fn3 25 103
Pfam A fn3 112 194
disorder n/a 116 117
Pfam A fn3 290 368
Pfam A fn3 378 460
Pfam A fn3 468 547
Pfam A fn3 555 633
low_complexity n/a 615 632
low_complexity n/a 639 657
Pfam A fn3 644 725
disorder n/a 646 648
disorder n/a 721 727
disorder n/a 730 736
Pfam A fn3 732 812
disorder n/a 806 825
Pfam A fn3 819 899
Pfam A fn3 908 985
Pfam A fn3 996 1077
disorder n/a 1042 1043
disorder n/a 1047 1051
disorder n/a 1085 1089
Pfam A fn3 1086 1165
Pfam A fn3 1174 1252
disorder n/a 1252 1257
Pfam A fn3 1262 1344
Pfam A fn3 1356 1435
disorder n/a 1358 1360
disorder n/a 1438 1459
low_complexity n/a 1448 1453
disorder n/a 1499 1509
transmembrane n/a 1616 1642
disorder n/a 1653 1655
Pfam A Y_phosphatase 1727 1962
disorder n/a 1992 1993
disorder n/a 1995 1996

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23467. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLSHGAGLAL WITLSLLQTG LAEPERCNFT LAESKASSHS VSIQWRILGS
50
51
PCNFSLIYSS DTLGAALCPT FRIDNTTYGC NLQDLQAGTI YNFRIISLDE
100
101
ERTVVLQTDP LPPARFGVSK EKTTSTSLHV WWTPSSGKVT SYEVQLFDEN
150
151
NQKIQGVQIQ ESTSWNEYTF FNLTAGSKYN IAITAVSGGK RSFSVYTNGS
200
201
TVPSPVKDIG ISTKANSLLI SWSHGSGNVE RYRLMLMDKG ILVHGGVVDK
250
251
HATSYAFHGL TPGYLYNLTV MTEAAGLQNY RWKLVRTAPM EVSNLKVTND
300
301
GSLTSLKVKW QRPPGNVDSY NITLSHKGTI KESRVLAPWI TETHFKELVP
350
351
GRLYQVTVSC VSGELSAQKM AVGRTFPDKV ANLEANNNGR MRSLVVSWSP
400
401
PAGDWEQYRI LLFNDSVVLL NITVGKEETQ YVMDDTGLVP GRQYEVEVIV
450
451
ESGNLKNSER CQGRTVPLAV LQLRVKHANE TSLSIMWQTP VAEWEKYIIS
500
501
LADRDLLLIH KSLSKDAKEF TFTDLVPGRK YMATVTSISG DLKNSSSVKG
550
551
RTVPAQVTDL HVANQGMTSS LFTNWTQAQG DVEFYQVLLI HENVVIKNES
600
601
ISSETSRYSF HSLKSGSLYS VVVTTVSGGI SSRQVVVEGR TVPSSVSGVT
650
651
VNNSGRNDYL SVSWLLAPGD VDNYEVTLSH DGKVVQSLVI AKSVRECSFS
700
701
SLTPGRLYTV TITTRSGKYE NHSFSQERTV PDKVQGVSVS NSARSDYLRV
750
751
SWVHATGDFD HYEVTIKNKN NFIQTKSIPK SENECVFVQL VPGRLYSVTV
800
801
TTKSGQYEAN EQGNGRTIPE PVKDLTLRNR STEDLHVTWS GANGDVDQYE
850
851
IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT ISGDVQQSAF
900
901
IEGFTVPSAV KNIHISPNGA TDSLTVNWTP GGGDVDSYTV SAFRHSQKVD
950
951
SQTIPKHVFE HTFHRLEAGE QYQIMIASVS GSLKNQINVV GRTVPASVQG
1000
1001
VIADNAYSSY SLIVSWQKAA GVAERYDILL LTENGILLRN TSEPATTKQH
1050
1051
KFEDLTPGKK YKIQILTVSG GLFSKEAQTE GRTVPAAVTD LRITENSTRH
1100
1101
LSFRWTASEG ELSWYNIFLY NPDGNLQERA QVDPLVQSFS FQNLLQGRMY
1150
1151
KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNTTDSL WFNWSPASGD
1200
1201
FDFYELILYN PNGTKKENWK DKDLTEWRFQ GLVPGRKYVL WVVTHSGDLS
1250
1251
NKVTAESRTA PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR
1300
1301
DALTVFNPYN NRKSEGRIVY GLRPGRSYQF NVKTVSGDSW KTYSKPIFGS
1350
1351
VRTKPDKIQN LHCRPQNSTA IACSWIPPDS DFDGYSIECR KMDTQEVEFS
1400
1401
RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMTSEVVEDS TITMIDRPPP
1450
1451
PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV VVREADGSDE
1500
1501
LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA
1550
1551
EMESLGGKCD PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY
1600
1601
SDTFFSLPIT TESEPLFGAI EGVSAGLFLI GMLVAVVALL ICRQKVSHGR
1650
1651
ERPSARLSIR RDRPLSVHLN LGQKGNRKTS CPIKINQFEG HFMKLQADSN
1700
1701
YLLSKEYEEL KDVGRNQSCD IALLPENRGK NRYNNILPYD ATRVKLSNVD
1750
1751
DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV WEQNVHNIVM
1800
1801
VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFKICG
1850
1851
EEQLDAHRLI RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT
1900
1901
VVHCSAGVGR TGTFIALDRI LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE
1950
1951
CQYVYLHQCV RDVLRARKLR SEQENPLFPI YENVNPEYHR DPVYSRH   
1997
 

Show the unformatted sequence.

Checksums:
CRC64:76E67B4A6109AA0F
MD5:4f0b3a2f80c11316a464d833916234ce

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Y_phosphatase 1727 - 1962 2AHS A 1727 - 1962 Jmol AstexViewer SPICE
B 1727 - 1962 Jmol AstexViewer SPICE
2H02 A 1727 - 1962 Jmol AstexViewer SPICE
B 1727 - 1962 Jmol AstexViewer SPICE
2H03 A 1727 - 1962 Jmol AstexViewer SPICE
2H04 A 1727 - 1962 Jmol AstexViewer SPICE
2HC1 A 1727 - 1962 Jmol AstexViewer SPICE
2HC2 A 1727 - 1962 Jmol AstexViewer SPICE
2I3R A 1727 - 1962 Jmol AstexViewer SPICE
B 1727 - 1962 Jmol AstexViewer SPICE
2I3U A 1727 - 1962 Jmol AstexViewer SPICE
2I4E A 1727 - 1962 Jmol AstexViewer SPICE
B 1727 - 1962 Jmol AstexViewer SPICE
2I4G A 1727 - 1962 Jmol AstexViewer SPICE
2I4H A 1727 - 1962 Jmol AstexViewer SPICE
2I5X A 1727 - 1962 Jmol AstexViewer SPICE
B 1727 - 1962 Jmol AstexViewer SPICE