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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTPRD_HUMAN (P23468)

Summary

This is the summary of UniProt entry PTPRD_HUMAN (P23468).

Description: Receptor-type tyrosine-protein phosphatase delta EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1912 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 20
low_complexity n/a 6 18
Pfam A I-set 24 115
disorder n/a 25 32
disorder n/a 56 57
disorder n/a 121 122
Pfam A I-set 126 225
disorder n/a 127 134
disorder n/a 145 148
disorder n/a 160 163
disorder n/a 174 180
disorder n/a 186 196
disorder n/a 199 209
low_complexity n/a 225 237
disorder n/a 235 245
Pfam A I-set 236 319
disorder n/a 281 288
Pfam A fn3 324 405
disorder n/a 325 331
disorder n/a 333 342
disorder n/a 354 355
disorder n/a 366 368
disorder n/a 402 424
Pfam A fn3 419 504
disorder n/a 435 436
disorder n/a 439 441
disorder n/a 449 454
disorder n/a 466 469
disorder n/a 506 510
disorder n/a 515 524
Pfam A fn3 517 597
disorder n/a 531 535
disorder n/a 547 550
disorder n/a 555 569
disorder n/a 594 619
Pfam A fn3 610 699
disorder n/a 621 623
disorder n/a 627 630
disorder n/a 648 650
disorder n/a 656 665
disorder n/a 685 692
disorder n/a 696 724
Pfam A fn3 713 812
disorder n/a 729 737
disorder n/a 743 753
disorder n/a 755 758
disorder n/a 760 765
disorder n/a 781 784
disorder n/a 798 804
disorder n/a 809 819
disorder n/a 821 824
Pfam A fn3 825 907
disorder n/a 826 829
disorder n/a 871 873
disorder n/a 914 915
disorder n/a 918 928
Pfam A fn3 921 1006
disorder n/a 930 932
disorder n/a 936 938
disorder n/a 992 993
disorder n/a 995 999
disorder n/a 1004 1007
disorder n/a 1094 1097
disorder n/a 1252 1255
transmembrane n/a 1267 1290
low_complexity n/a 1274 1289
disorder n/a 1300 1319
disorder n/a 1321 1325
Pfam A Y_phosphatase 1380 1611
Pfam A Y_phosphatase 1669 1902

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23468. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
50
51
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
100
101
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
150
151
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
200
201
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
250
251
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
300
301
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP
350
351
VSYYIIQHKP KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG
400
401
RGPPSEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
450
451
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
500
501
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV
550
551
YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI
600
601
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT
650
651
AVDGEDDKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
700
701
SVLIRTNEDV PSGPPRKVEV EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH
750
751
YVRMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
800
801
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
850
851
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
900
901
VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI
950
951
ITKYTLLYRD INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK
1000
1001
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1050
1051
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1100
1101
AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY YIIIVPLKKS
1150
1151
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1200
1201
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV
1250
1251
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR
1300
1301
KSSIPNNKEI PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1350
1351
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1400
1401
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1450
1451
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1500
1501
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1550
1551
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1600
1601
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1650
1651
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1700
1701
NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1750
1751
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1800
1801
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1850
1851
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA
1900
1901
LEYLGSFDHY AT                                         
1912
 

Show the unformatted sequence.

Checksums:
CRC64:3AE8CBCD32182E26
MD5:d832004c2b6ac2882d8310cbc0e113e8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
fn3 419 - 504 2DLH A 20 - 105 Jmol AstexViewer SPICE
517 - 597 1X5Z A 19 - 99 Jmol AstexViewer SPICE
I-set 126 - 225 2YD6 A 126 - 219 Jmol AstexViewer SPICE
2YD7 A 126 - 219 Jmol AstexViewer SPICE
B 126 - 219 Jmol AstexViewer SPICE
24 - 115 2YD6 A 24 - 115 Jmol AstexViewer SPICE
2YD7 A 24 - 115 Jmol AstexViewer SPICE
B 24 - 115 Jmol AstexViewer SPICE