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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTPRG_HUMAN (P23470)

Summary

This is the summary of UniProt entry PTPRG_HUMAN (P23470).

Description: Receptor-type tyrosine-protein phosphatase gamma EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1445 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
transmembrane n/a 7 25
Pfam A Carb_anhydrase 60 321
disorder n/a 163 164
disorder n/a 299 300
Pfam A fn3 348 436
disorder n/a 393 406
disorder n/a 460 461
disorder n/a 465 475
low_complexity n/a 474 484
disorder n/a 491 496
disorder n/a 498 507
low_complexity n/a 515 525
disorder n/a 528 730
low_complexity n/a 572 610
transmembrane n/a 737 762
disorder n/a 776 789
disorder n/a 860 873
Pfam A Y_phosphatase 874 1118
disorder n/a 1000 1009
Pfam A Y_phosphatase 1175 1409
disorder n/a 1178 1182
disorder n/a 1423 1429
disorder n/a 1442 1445

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23470. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR
50
51
RRKASGDPYW AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ
100
101
ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF
150
151
HWGHSNGSAG SEHSINGRRF PVEMQIFFYN PDDFDSFQTA ISENRIIGAM
200
201
AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD LLPASLGSYY
250
251
RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE
300
301
YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP
350
351
IHMKVQPLNQ TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK
400
401
DSDKDLKATI SHVSPDSLYL FRVQAVCRND MRSDFSQTML FQANTTRIFQ
450
451
GTRIVKTGVP TASPASSADM APISSGSSTW TSSGIPFSFV SMATGMGPSS
500
501
SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT AASASKQAAR
550
551
PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE
600
601
KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA
650
651
VPTDQTGGRR DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP
700
701
MSRGDRFSED SRFITVNPAE KNTSGMISRP APGRMEWIIP LIVVSALTFV
750
751
CLILLIAVLV YWRGCNKIKS KGFPRRFREV PSSGERGEKG SRKCFQTAHF
800
801
YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL YSNNQHGFSE
850
851
DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD
900
901
SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI
950
951
TNLVEKGRRK CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK
1000
1001
VKKGQKGNPK GRQNERVVIQ YHYTQWPDMG VPEYALPVLT FVRRSSAARM
1050
1051
PETGPVLVHC SAGVGRTGTY IVIDSMLQQI KDKSTVNVLG FLKHIRTQRN
1100
1101
YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL IPGVGGKTRL
1150
1151
EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM
1200
1201
KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP
1250
1251
DNQSLAEDEF VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL
1300
1301
EATQDDYVLE VRHFQCPKWP NPDAPISSTF ELINVIKEEA LTRDGPTIVH
1350
1351
DEYGAVSAGM LCALTTLSQQ LENENAVDVF QVAKMINLMR PGVFTDIEQY
1400
1401
QFIYKAMLSL VSTKENGNGP MTVDKNGAVL IADESDPAES MESLV     
1445
 

Show the unformatted sequence.

Checksums:
CRC64:A48A007BA14082BC
MD5:a990f827db4eb6af783807dbe47e58c5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Carb_anhydrase 60 - 320 3JXH C 60 - 320 Jmol AstexViewer SPICE
Y_phosphatase 1175 - 1409 2NLK A 1175 - 1409 Jmol AstexViewer SPICE
874 - 1118 2H4V A 874 - 1118 Jmol AstexViewer SPICE
B 874 - 1118 Jmol AstexViewer SPICE
2HY3 A 874 - 1118 Jmol AstexViewer SPICE
B 874 - 1118 Jmol AstexViewer SPICE
2NLK A 874 - 1118 Jmol AstexViewer SPICE
2PBN A 874 - 1118 Jmol AstexViewer SPICE
3QCB A 874 - 1118 Jmol AstexViewer SPICE
B 874 - 1118 Jmol AstexViewer SPICE
3QCC A 874 - 1118 Jmol AstexViewer SPICE
B 874 - 1118 Jmol AstexViewer SPICE
3QCD A 874 - 1118 Jmol AstexViewer SPICE
3QCE A 874 - 1118 Jmol AstexViewer SPICE
B 874 - 1118 Jmol AstexViewer SPICE
3QCF A 874 - 1118 Jmol AstexViewer SPICE
B 874 - 1118 Jmol AstexViewer SPICE
3QCG A 874 - 1118 Jmol AstexViewer SPICE
3QCH A 874 - 1118 Jmol AstexViewer SPICE
3QCI A 874 - 1118 Jmol AstexViewer SPICE
3QCJ A 874 - 1118 Jmol AstexViewer SPICE
3QCK A 874 - 1118 Jmol AstexViewer SPICE
3QCL A 874 - 1118 Jmol AstexViewer SPICE
3QCM A 874 - 1118 Jmol AstexViewer SPICE
B 874 - 1118 Jmol AstexViewer SPICE
3QCN A 874 - 1118 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.