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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTPRZ_HUMAN (P23471)

Summary

This is the summary of UniProt entry PTPRZ_HUMAN (P23471).

Description: Receptor-type tyrosine-protein phosphatase zeta EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2315 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 22
Pfam A Carb_anhydrase 38 300
disorder n/a 311 314
Pfam A fn3 313 401
disorder n/a 415 416
disorder n/a 419 423
low_complexity n/a 420 442
disorder n/a 428 430
disorder n/a 432 565
Pfam B Pfam-B_19963 441 519
Pfam B Pfam-B_21409 521 639
disorder n/a 573 596
disorder n/a 618 661
low_complexity n/a 631 642
Pfam B Pfam-B_25585 641 1660
disorder n/a 664 681
disorder n/a 684 706
disorder n/a 729 732
disorder n/a 739 740
disorder n/a 750 751
disorder n/a 754 758
disorder n/a 787 788
low_complexity n/a 817 829
disorder n/a 911 932
disorder n/a 988 989
disorder n/a 991 995
disorder n/a 1000 1003
disorder n/a 1058 1062
disorder n/a 1075 1078
disorder n/a 1110 1111
disorder n/a 1116 1119
disorder n/a 1121 1132
disorder n/a 1134 1158
low_complexity n/a 1145 1159
disorder n/a 1297 1300
disorder n/a 1304 1305
disorder n/a 1361 1363
disorder n/a 1371 1381
disorder n/a 1387 1395
disorder n/a 1398 1400
disorder n/a 1403 1444
low_complexity n/a 1409 1436
disorder n/a 1447 1577
disorder n/a 1579 1615
low_complexity n/a 1612 1623
disorder n/a 1620 1626
transmembrane n/a 1637 1662
low_complexity n/a 1682 1693
Pfam A Y_phosphatase 1750 1991
disorder n/a 1881 1884
Pfam A Y_phosphatase 2048 2281
disorder n/a 2218 2221
disorder n/a 2290 2301

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23471. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG
50
51
KKYPTCNSPK QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK
100
101
TVEINLTNDY RVSGGVSEMV FKASKITFHW GKCNMSSDGS EHSLEGQKFP
150
151
LEMQIYCFDA DRFSSFEEAV KGKGKLRALS ILFEVGTEEN LDFKAIIDGV
200
201
ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC TDTVDWIVFK
250
251
DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY
300
301
TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRVVYD TMIEKFAVLY
350
351
QQLDGEDQTK HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY
400
401
SDQLIVDMPT DNPELDLFPE LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA
450
451
TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN RSPTRGSEFS GKGDVPNTSL
500
501
NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND GSKTVLRSPH
550
551
MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS
600
601
ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG
650
651
NVWFPSSTDI TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS
700
701
QGPSVTDLEM PHYSTFAYFP TEVTPHAFTP SSRQQDLVST VNVVYSQTTQ
750
751
PVYNGETPLQ PSYSSEVFPL VTPLLLDNQI LNTTPAASSS DSALHATPVF
800
801
PSVDVSFESI LSSYDGAPLL PFSSASFSSE LFRHLHTVSQ ILPQVTSATE
850
851
SDKVPLHASL PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY
900
901
KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVSYSSAIPV
950
951
HDSVGVTYQG SLFSGPSHIP IPKSSLITPT ASLLQPTHAL SGDGEWSGAS
1000
1001
SDSEFLLPDT DGLTALNISS PVSVAEFTYT TSVFGDDNKA LSKSEIIYGN
1050
1051
ETELQIPSFN EMVYPSESTV MPNMYDNVNK LNASLQETSV SISSTKGMFP
1100
1101
GSLAHTTTKV FDHEISQVPE NNFSVQPTHT VSQASGDTSL KPVLSANSEP
1150
1151
ASSDPASSEM LSPSTQLLFY ETSASFSTEV LLQPSFQASD VDTLLKTVLP
1200
1201
AVPSDPILVE TPKVDKISST MLHLIVSNSA SSENMLHSTS VPVFDVSPTS
1250
1251
HMHSASLQGL TISYASEKYE PVLLKSESSH QVVPSLYSND ELFQTANLEI
1300
1301
NQAHPPKGRH VFATPVLSID EPLNTLINKL IHSDEILTST KSSVTGKVFA
1350
1351
GIPTVASDTF VSTDHSVPIG NGHVAITAVS PHRDGSVTST KLLFPSKATS
1400
1401
ELSHSAKSDA GLVGGGEDGD TDDDGDDDDD DRGSDGLSIH KCMSCSSYRE
1450
1451
SQEKVMNDSD THENSLMDQN NPISYSLSEN SEEDNRVTSV SSDSQTGMDR
1500
1501
SPGKSPSANG LSQKHNDGKE ENDIQTGSAL LPLSPESKAW AVLTSDEESG
1550
1551
SGQGTSDSLN ENETSTDFSF ADTNEKDADG ILAAGDSEIT PGFPQSPTSS
1600
1601
VTSENSEVFH VSEAEASNSS HESRIGLAEG LESEKKAVIP LVIVSALTFI
1650
1651
CLVVLVGILI YWRKCFQTAH FYLEDSTSPR VISTPPTPIF PISDDVGAIP
1700
1701
IKHFPKHVAD LHASSGFTEE FETLKEFYQE VQSCTVDLGI TADSSNHPDN
1750
1751
KHKNRYINIV AYDHSRVKLA QLAEKDGKLT DYINANYVDG YNRPKAYIAA
1800
1801
QGPLKSTAED FWRMIWEHNV EVIVMITNLV EKGRRKCDQY WPADGSEEYG
1850
1851
NFLVTQKSVQ VLAYYTVRNF TLRNTKIKKG SQKGRPSGRV VTQYHYTQWP
1900
1901
DMGVPEYSLP VLTFVRKAAY AKRHAVGPVV VHCSAGVGRT GTYIVLDSML
1950
1951
QQIQHEGTVN IFGFLKHIRS QRNYLVQTEE QYVFIHDTLV EAILSKETEV
2000
2001
LDSHIHAYVN ALLIPGPAGK TKLEKQFQLL SQSNIQQSDY SAALKQCNRE
2050
2051
KNRTSSIIPV ERSRVGISSL SGEGTDYINA SYIMGYYQSN EFIITQHPLL
2100
2101
HTIKDFWRMI WDHNAQLVVM IPDGQNMAED EFVYWPNKDE PINCESFKVT
2150
2151
LMAEEHKCLS NEEKLIIQDF ILEATQDDYV LEVRHFQCPK WPNPDSPISK
2200
2201
TFELISVIKE EAANRDGPMI VHDEHGGVTA GTFCALTTLM HQLEKENSVD
2250
2251
VYQVAKMINL MRPGVFADIE QYQFLYKVIL SLVSTRQEEN PSTSLDSNGA
2300
2301
ALPDGNIAES LESLV                                      
2315
 

Show the unformatted sequence.

Checksums:
CRC64:ED9DD98D4CCA2883
MD5:09a571e256ba5d0c9c7170490ba379ab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Carb_anhydrase 38 - 300 3JXF A 38 - 300 Jmol AstexViewer SPICE
B 38 - 300 Jmol AstexViewer SPICE
3S97 A 38 - 300 Jmol AstexViewer SPICE
B 38 - 300 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.