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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: FSHR_HUMAN (P23945)

Summary

This is the summary of UniProt entry FSHR_HUMAN (P23945).

Description: Follicle-stimulating hormone receptor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 695 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 17
low_complexity n/a 2 14
Pfam A LRRNT 17 45
Pfam A LRR_8 95 150
Pfam A LRR_8 193 246
low_complexity n/a 195 212
Pfam A GnHR_trans 280 349
transmembrane n/a 367 387
Pfam A 7tm_1 379 626
transmembrane n/a 399 424
transmembrane n/a 444 465
transmembrane n/a 486 509
low_complexity n/a 495 508
transmembrane n/a 529 554
transmembrane n/a 575 597
transmembrane n/a 609 629
disorder n/a 665 667
disorder n/a 670 672

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23945. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE
50
51
LRFVLTKLRV IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI
100
101
RIEKANNLLY INPEAFQNLP NLQYLLISNT GIKHLPDVHK IHSLQKVLLD
150
151
IQDNINIHTI ERNSFVGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL
200
201
SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN LKKLRARSTY
250
251
NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE
300
301
VDYMTQARGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP
350
351
DAFNPCEDIM GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL
400
401
MCNLAFADLC IGIYLLLIAS VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV
450
451
FASELSVYTL TAITLERWHT ITHAMQLDCK VQLRHAASVM VMGWIFAFAA
500
501
ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL AFVVICGCYI
550
551
HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP
600
601
LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ
650
651
AQIYRTETSS TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN     
695
 

Show the unformatted sequence.

Checksums:
CRC64:766BC421014CD5A4
MD5:a68e26905ba58a65e0870841cfd6ec44

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LRR_8 193 - 246 1XWD C 193 - 246 Jmol AstexViewer SPICE
F 193 - 246 Jmol AstexViewer SPICE
95 - 150 1XWD C 95 - 150 Jmol AstexViewer SPICE
F 95 - 150 Jmol AstexViewer SPICE
LRRNT 18 - 45 1XWD C 18 - 45 Jmol AstexViewer SPICE
F 18 - 45 Jmol AstexViewer SPICE