Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DMA_HUMAN (P28067)

Summary

This is the summary of UniProt entry DMA_HUMAN (P28067).

Description: HLA class II histocompatibility antigen, DM alpha chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 261 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 26
low_complexity n/a 11 21
Pfam A MHC_II_alpha 41 124
Pfam A C1-set 133 212
transmembrane n/a 234 254
low_complexity n/a 238 252

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P28067. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC
50
51
QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF
100
101
DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS
150
151
NLFPPMLTVN WHDHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF
200
201
SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL
250
251
IIYFRKPCSG D                                          
261
 

Show the unformatted sequence.

Checksums:
CRC64:1986C3C1989F02E9
MD5:f57ebe41648962e4cef2b4141875b42d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1-set 133 - 212 1HDM A 104 - 183 Jmol AstexViewer SPICE
2BC4 A 107 - 186 Jmol AstexViewer SPICE
C 107 - 186 Jmol AstexViewer SPICE
MHC_II_alpha 41 - 124 1HDM A 15 - 95 Jmol AstexViewer SPICE
2BC4 A 15 - 98 Jmol AstexViewer SPICE
C 15 - 98 Jmol AstexViewer SPICE