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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DMB_HUMAN (P28068)

Summary

This is the summary of UniProt entry DMB_HUMAN (P28068).

Description: HLA class II histocompatibility antigen, DM beta chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 263 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 17
low_complexity n/a 5 20
Pfam A MHC_II_beta 27 106
disorder n/a 116 122
Pfam A C1-set 121 204
disorder n/a 158 162
transmembrane n/a 219 240

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P28068. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MITFLPLLLG LSLGCTGAGG FVAHVESTCL LDDAGTPKDF TYCISFNKDL
50
51
LTCWDPEENK MAPCEFGVLN SLANVLSQHL NQKDTLMQRL RNGLQNCATH
100
101
TQPFWGSLTN RTRPPSVQVA KTTPFNTREP VMLACYVWGF YPAEVTITWR
150
151
KNGKLVMPHS SAHKTAQPNG DWTYQTLSHL ALTPSYGDTY TCVVEHIGAP
200
201
EPILRDWTPG LSPMQTLKVS VSAVTLGLGL IIFSLGVISW RRAGHSSYTP
250
251
LPGSNYSEGW HIS                                        
263
 

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Checksums:
CRC64:9B50F6CC22B3A4BA
MD5:9f70b36b3216b6f236bedcc2a706fd7f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1-set 121 - 204 1HDM B 97 - 179 Jmol AstexViewer SPICE
2BC4 B 103 - 186 Jmol AstexViewer SPICE
D 103 - 186 Jmol AstexViewer SPICE
MHC_II_beta 27 - 106 1HDM B 9 - 82 Jmol AstexViewer SPICE
2BC4 B 9 - 88 Jmol AstexViewer SPICE
D 9 - 88 Jmol AstexViewer SPICE