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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MK01_HUMAN (P28482)

Summary

This is the summary of UniProt entry MK01_HUMAN (P28482).

Description: Mitogen-activated protein kinase 1 EC=2.7.11.24
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 360 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 16
low_complexity n/a 2 10
Pfam A Pkinase 25 313
low_complexity n/a 332 346

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P28482. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR
50
51
VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD
100
101
VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL
150
151
KPSNLLLNTT CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML
200
201
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE
250
251
DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK
300
301
RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE
350
351
TARFQPGYRS                                            
360
 

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Checksums:
CRC64:E85D0B2A5D2D724E
MD5:ccb174681d880da0eae8c0c11a73434c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 25 - 313 1PME A 25 - 313 Jmol AstexViewer SPICE
1TVO A 25 - 313 Jmol AstexViewer SPICE
1WZY A 25 - 313 Jmol AstexViewer SPICE
2E14 A 25 - 313 Jmol AstexViewer SPICE
2OJG A 23 - 311 Jmol AstexViewer SPICE
2OJI A 23 - 311 Jmol AstexViewer SPICE
2OJJ A 23 - 311 Jmol AstexViewer SPICE
2Y9Q A 25 - 313 Jmol AstexViewer SPICE
3I5Z A 23 - 311 Jmol AstexViewer SPICE
3I60 A 23 - 311 Jmol AstexViewer SPICE
3SA0 A 25 - 313 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.