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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTPRM_HUMAN (P28827)

Summary

This is the summary of UniProt entry PTPRM_HUMAN (P28827).

Description: Receptor-type tyrosine-protein phosphatase mu EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1452 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 20
low_complexity n/a 3 22
Pfam A MAM 27 184
disorder n/a 49 51
disorder n/a 82 84
Pfam A ig 199 262
Pfam A fn3 283 366
disorder n/a 334 339
disorder n/a 351 358
disorder n/a 360 377
disorder n/a 381 384
disorder n/a 431 448
disorder n/a 471 478
disorder n/a 485 488
Pfam A fn3 487 575
disorder n/a 534 537
disorder n/a 590 592
disorder n/a 635 636
disorder n/a 725 738
transmembrane n/a 743 764
low_complexity n/a 745 763
low_complexity n/a 765 774
disorder n/a 772 784
disorder n/a 788 790
disorder n/a 819 828
disorder n/a 836 844
disorder n/a 847 849
disorder n/a 851 874
disorder n/a 919 921
Pfam A Y_phosphatase 923 1153
Pfam A Y_phosphatase 1213 1447

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P28827. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ
50
51
VNTLTKPTSD PWMPSGSFML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH
100
101
YFVSSKSNSP PGLLNVYVKV NNGPLGNPIW NISGDPTRTW NRAELAISTF
150
151
WPNFYQVIFE VITSGHQGYL AIDEVKVLGH PCTRTPHFLR IQNVEVNAGQ
200
201
FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR FIASFNVVNT
250
251
TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI
300
301
QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE
350
351
ISVLLTRPGE GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW
400
401
EPFGYNVTRC HSYNLTVHYC YQVGGQEQVR EEVSWDTENS HPQHTITNLS
450
451
PYTNVSVKLI LMNPEGRKES QELIVQTDED LPGAVPTESI QGSTFEEKIF
500
501
LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS KLGNETHFLF
550
551
FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT
600
601
DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ
650
651
NASLLNSQYY FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI
700
701
YFQAASRANG ETKIDCVQVA TKGAATPKPV PEPEKQTDHT VKIAGVIAGI
750
751
LLFVIIFLGV VLVMKKRKLA KKRKETMSST RQEMTVMVNS MDKSYAEQGT
800
801
NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY YPDETHTMAS
850
851
DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF
900
901
KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN
950
951
SDYINGNYID GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL
1000
1001
VEVGRVKCCK YWPDDTEIYK DIKVTLIETE LLAEYVIRTF AVEKRGVHEI
1050
1051
REIRQFHFTG WPDHGVPYHA TGLLGFVRQV KSKSPPSAGP LVVHCSAGAG
1100
1101
RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT EEQYVFIHDA
1150
1151
ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL
1200
1201
RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS
1250
1251
YKQPSAFIVT QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP
1300
1301
ENGVHRHGPI QVEFVSADLE EDIISRIFRI YNAARPQDGY RMVQQFQFLG
1350
1351
WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG GEGRTVVHCL NGGGRSGTFC
1400
1401
AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF CYEVALEYLN
1450
1451
SG                                                    
1452
 

Show the unformatted sequence.

Checksums:
CRC64:8319E3D3A583E992
MD5:ec45c27087b0a314e4fe033fc490b38a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
fn3 283 - 366 2V5Y A 263 - 346 Jmol AstexViewer SPICE
487 - 575 2V5Y A 467 - 555 Jmol AstexViewer SPICE
ig 199 - 262 2C9A A 199 - 262 Jmol AstexViewer SPICE
2V5Y A 179 - 242 Jmol AstexViewer SPICE
MAM 27 - 184 2C9A A 27 - 184 Jmol AstexViewer SPICE
2V5Y A 7 - 164 Jmol AstexViewer SPICE
Y_phosphatase 923 - 1153 1RPM A 923 - 1153 Jmol AstexViewer SPICE
B 923 - 1153 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.