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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HXK4_HUMAN (P35557)

Summary

This is the summary of UniProt entry HXK4_HUMAN (P35557).

Description: Glucokinase EC=2.7.1.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 465 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 3 4
disorder n/a 6 7
Pfam A Hexokinase_1 10 217
coiled_coil n/a 13 40
disorder n/a 41 46
disorder n/a 48 49
disorder n/a 56 62
disorder n/a 102 103
Pfam A Hexokinase_2 219 458
low_complexity n/a 301 310

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P35557. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLDDRARMEA AKKEKVEQIL AEFQLQEEDL KKVMRRMQKE MDRGLRLETH
50
51
EEASVKMLPT YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEEGQWS
100
101
VKTKHQMYSI PEDAMTGTAE MLFDYISECI SDFLDKHQMK HKKLPLGFTF
150
151
SFPVRHEDID KGILLNWTKG FKASGAEGNN VVGLLRDAIK RRGDFEMDVV
200
201
AMVNDTVATM ISCYYEDHQC EVGMIVGTGC NACYMEEMQN VELVEGDEGR
250
251
MCVNTEWGAF GDSGELDEFL LEYDRLVDES SANPGQQLYE KLIGGKYMGE
300
301
LVRLVLLRLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DTGDRKQIYN
350
351
ILSTLGLRPS TTDCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED
400
401
VMRITVGVDG SVYKLHPSFK ERFHASVRRL TPSCEITFIE SEEGSGRGAA
450
451
LVSAVACKKA CMLGQ                                      
465
 

Show the unformatted sequence.

Checksums:
CRC64:094D4A2F78096724
MD5:3a1a81c56bb6632f341321c6ee146554

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Hexokinase_1 10 - 217 4DCH A 10 - 217 Jmol AstexViewer SPICE
12 - 217 3F9M A 12 - 217 Jmol AstexViewer SPICE
3FGU A 12 - 217 Jmol AstexViewer SPICE
3ID8 A 12 - 217 Jmol AstexViewer SPICE
3IDH A 12 - 217 Jmol AstexViewer SPICE
3QIC A 12 - 217 Jmol AstexViewer SPICE
3S41 A 12 - 217 Jmol AstexViewer SPICE
3VEV A 12 - 217 Jmol AstexViewer SPICE
3VF6 A 12 - 217 Jmol AstexViewer SPICE
4DHY A 12 - 217 Jmol AstexViewer SPICE
16 - 217 1V4S A 16 - 217 Jmol AstexViewer SPICE
1V4T A 16 - 217 Jmol AstexViewer SPICE
3A0I X 16 - 217 Jmol AstexViewer SPICE
3FR0 A 16 - 217 Jmol AstexViewer SPICE
3GOI A 16 - 217 Jmol AstexViewer SPICE
3H1V X 16 - 217 Jmol AstexViewer SPICE
3IMX A 16 - 217 Jmol AstexViewer SPICE
3VEY A 16 - 217 Jmol AstexViewer SPICE
Hexokinase_2 219 - 457 3ID8 A 219 - 457 Jmol AstexViewer SPICE
3IDH A 219 - 457 Jmol AstexViewer SPICE
219 - 458 1V4S A 219 - 458 Jmol AstexViewer SPICE
1V4T A 219 - 458 Jmol AstexViewer SPICE
3A0I X 219 - 458 Jmol AstexViewer SPICE
3F9M A 219 - 458 Jmol AstexViewer SPICE
3FGU A 219 - 458 Jmol AstexViewer SPICE
3FR0 A 219 - 458 Jmol AstexViewer SPICE
3GOI A 219 - 458 Jmol AstexViewer SPICE
3H1V X 219 - 458 Jmol AstexViewer SPICE
3IMX A 219 - 458 Jmol AstexViewer SPICE
3QIC A 219 - 458 Jmol AstexViewer SPICE
3S41 A 219 - 458 Jmol AstexViewer SPICE
3VEV A 219 - 458 Jmol AstexViewer SPICE
3VEY A 219 - 458 Jmol AstexViewer SPICE
3VF6 A 219 - 458 Jmol AstexViewer SPICE
4DCH A 219 - 458 Jmol AstexViewer SPICE
4DHY A 219 - 458 Jmol AstexViewer SPICE