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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ACTN2_HUMAN (P35609)

Summary

This is the summary of UniProt entry ACTN2_HUMAN (P35609).

Description: Alpha-actinin-2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 894 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam B Pfam-B_7425 19 40
Pfam A CH 41 142
Pfam A CH 154 257
low_complexity n/a 255 266
coiled_coil n/a 272 299
Pfam A Spectrin 281 391
disorder n/a 310 311
disorder n/a 314 319
disorder n/a 322 323
disorder n/a 326 327
low_complexity n/a 386 404
coiled_coil n/a 389 409
Pfam A Spectrin 401 506
coiled_coil n/a 437 471
coiled_coil n/a 493 520
Pfam A Spectrin 516 627
disorder n/a 562 563
disorder n/a 572 573
disorder n/a 629 631
Pfam A Spectrin 637 740
coiled_coil n/a 671 705
Pfam A EFhand_Ca_insen 824 890

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P35609. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNQIEPGVQY NYVYDEDEYM IQEEEWDRDL LLDPAWEKQQ RKTFTAWCNS
50
51
HLRKAGTQIE NIEEDFRNGL KLMLLLEVIS GERLPKPDRG KMRFHKIANV
100
101
NKALDYIASK GVKLVSIGAE EIVDGNVKMT LGMIWTIILR FAIQDISVEE
150
151
TSAKEGLLLW CQRKTAPYRN VNIQNFHTSW KDGLGLCALI HRHRPDLIDY
200
201
SKLNKDDPIG NINLAMEIAE KHLDIPKMLD AEDIVNTPKP DERAIMTYVS
250
251
CFYHAFAGAE QAETAANRIC KVLAVNQENE RLMEEYERLA SELLEWIRRT
300
301
IPWLENRTPE KTMQAMQKKL EDFRDYRRKH KPPKVQEKCQ LEINFNTLQT
350
351
KLRISNRPAF MPSEGKMVSD IAGAWQRLEQ AEKGYEEWLL NEIRRLERLE
400
401
HLAEKFRQKA STHETWAYGK EQILLQKDYE SASLTEVRAL LRKHEAFESD
450
451
LAAHQDRVEQ IAAIAQELNE LDYHDAVNVN DRCQKICDQW DRLGTLTQKR
500
501
REALERMEKL LETIDQLHLE FAKRAAPFNN WMEGAMEDLQ DMFIVHSIEE
550
551
IQSLITAHEQ FKATLPEADG ERQSIMAIQN EVEKVIQSYN IRISSSNPYS
600
601
TVTMDELRTK WDKVKQLVPI RDQSLQEELA RQHANERLRR QFAAQANAIG
650
651
PWIQNKMEEI ARSSIQITGA LEDQMNQLKQ YEHNIINYKN NIDKLEGDHQ
700
701
LIQEALVFDN KHTNYTMEHI RVGWELLLTT IARTINEVET QILTRDAKGI
750
751
TQEQMNEFRA SFNHFDRRKN GLMDHEDFRA CLISMGYDLG EAEFARIMTL
800
801
VDPNGQGTVT FQSFIDFMTR ETADTDTAEQ VIASFRILAS DKPYILAEEL
850
851
RRELPPDQAQ YCIKRMPAYS GPGSVPGALD YAAFSSALYG ESDL      
894
 

Show the unformatted sequence.

Checksums:
CRC64:7F612C1C3B3E2299
MD5:0032b33b80d951c763190fadc27791f2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EFhand_Ca_insen 824 - 890 1H8B A 3 - 69 Jmol AstexViewer SPICE
Spectrin 281 - 391 1HCI A 281 - 391 Jmol AstexViewer SPICE
B 281 - 391 Jmol AstexViewer SPICE
401 - 506 1HCI A 401 - 506 Jmol AstexViewer SPICE
B 401 - 506 Jmol AstexViewer SPICE
1QUU A 14 - 119 Jmol AstexViewer SPICE
516 - 627 1HCI A 516 - 627 Jmol AstexViewer SPICE
B 516 - 627 Jmol AstexViewer SPICE
1QUU A 129 - 240 Jmol AstexViewer SPICE
637 - 740 1HCI A 637 - 740 Jmol AstexViewer SPICE
B 637 - 740 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.