Summary
This is the summary of UniProt entry HNF1B_HUMAN (P35680).
| Description: | Hepatocyte nuclear factor 1-beta |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 557 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | HNF-1_N | 1 | 182 |
| low_complexity | n/a | 5 | 19 |
| disorder | n/a | 41 | 116 |
| low_complexity | n/a | 75 | 85 |
| disorder | n/a | 121 | 122 |
| disorder | n/a | 124 | 128 |
| disorder | n/a | 132 | 133 |
| disorder | n/a | 135 | 159 |
| disorder | n/a | 183 | 194 |
| disorder | n/a | 215 | 235 |
| Pfam A | Homeobox | 232 | 307 |
| disorder | n/a | 247 | 266 |
| disorder | n/a | 276 | 282 |
| disorder | n/a | 284 | 285 |
| disorder | n/a | 310 | 318 |
| Pfam A | HNF-1B_C | 314 | 551 |
| disorder | n/a | 320 | 369 |
| low_complexity | n/a | 328 | 344 |
| disorder | n/a | 371 | 410 |
| disorder | n/a | 413 | 436 |
| disorder | n/a | 473 | 475 |
| disorder | n/a | 477 | 495 |
| disorder | n/a | 497 | 501 |
| disorder | n/a | 507 | 529 |
| low_complexity | n/a | 537 | 549 |
| disorder | n/a | 539 | 540 |
| disorder | n/a | 544 | 545 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P35680. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MVSKLTSLQQ ELLSALLSSG VTKEVLVQAL EELLPSPNFG VKLETLPLSP
50 51
GSGAEPDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT
100 101
EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL
150 151
SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD
200 201
QLLFLFPEFS QQSHGPGQSD DACSEPTNKK MRRNRFKWGP ASQQILYQAY
250 251
DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF
300 301
ANRRKEEAFR QKLAMDAYSS NQTHSLNPLL SHGSPHHQPS SSPPNKLSGV
350 351
RYSQQGNNEI TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHNLLSPDG
400 401
KMISVSGGGL PPVSTLTNIH SLSHHNPQQS QNLIMTPLSG VMAIAQSLNT
450 451
SQAQSVPVIN SVAGSLAALQ PVQFSQQLHS PHQQPLMQQS PGSHMAQQPF
500 501
MAAVTQLQNS HMYAHKQEPP QYSHTSRFPS AMVVTDTSSI STLTNMSSSK
550 551
QCPLQAW
557
Show the unformatted sequence. |
| Checksums: |
CRC64:9E1ECC7423B73980
MD5:96376ec07d248fed4afb6fa38c6670e7
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| HNF-1_N | 91 - 182 | 2H8R | A | 91 - 182 | Jmol AstexViewer SPICE |
| B | 91 - 182 | Jmol AstexViewer SPICE | |||
| HNF-1B_C | 314 - 321 | 2DA6 | A | 89 - 96 | Jmol AstexViewer SPICE |
| Homeobox | 232 - 307 | 2H8R | A | 232 - 307 | Jmol AstexViewer SPICE |
| B | 232 - 307 | Jmol AstexViewer SPICE | |||
| 233 - 307 | 2DA6 | A | 8 - 82 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.