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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DYHC_YEAST (P36022)

Summary

This is the summary of UniProt entry DYHC_YEAST (P36022).

Description: Dynein heavy chain, cytoplasmic
Source organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (NCBI taxonomy ID 559292)
View Pfam proteome data.
Length: 4092 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam B Pfam-B_4644 1 109
Pfam B Pfam-B_130586 111 169
Pfam A DHC_N1 215 768
Pfam B Pfam-B_102874 851 989
Pfam B Pfam-B_3655 991 1149
Pfam B Pfam-B_130592 1151 1209
Pfam A DHC_N2 1219 1631
coiled_coil n/a 1684 1704
Pfam A AAA_6 1758 1985
Pfam A AAA_5 2069 2210
Pfam B Pfam-B_130595 2271 2379
Pfam A AAA_7 2381 2651
low_complexity n/a 2690 2702
Pfam A AAA_8 2726 2956
coiled_coil n/a 2993 3013
Pfam A MT 3014 3352
coiled_coil n/a 3021 3051
low_complexity n/a 3036 3051
disorder n/a 3040 3068
disorder n/a 3072 3075
Pfam A AAA_9 3370 3598
coiled_coil n/a 3534 3572
low_complexity n/a 3550 3572
coiled_coil n/a 3580 3607
transmembrane n/a 3640 3658
Pfam A Dynein_heavy 3753 4032
low_complexity n/a 4038 4041

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P36022. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MCKNEARLAN ELIEFVAATV TGIKNSPKEN EQAFIDYLHC QYLERFQFFL
50
51
GLLDGREFDT LFVFLFEELD RTIVTIDIGE EAIYDANLAN KKYSTLLIIK
100
101
SRSVIVDAEP IATQISAIYL PGPVNAGNLA SIITHGVSSV FGQLIKSDTK
150
151
TYSVETIDKT RRKLDDISKQ FQQLHTSIET PDLLAMVPSI IKLAVSKGAT
200
201
SHDYANYLPS NDLESMRFLN ILQSIANKWF LVLKQTLAID RDIKNGSFLD
250
251
EVEFWSNFYE VLKSLIEQTQ SQEFQVCLSV LTNAKRFHNL TNLLNEGSLS
300
301
DKFKLADKYN QFLSSIPIDE VRQASNLEDL QELFPVLASS LKKFRYSGYP
350
351
VQRFVVLMDK ISQEVMDAIL SNLSDLFQLE YGSFLGLYEK SAGMIEEWDD
400
401
IVQDVNLLIR EDLRKRAPQE LLIQKLTFTS ASVKATLDEI LSTRKRFFSL
450
451
AETIKSISPS TYHEEIQRLY HPFEQIHDIS VNFRLKLEQA ESEFSKNMLD
500
501
LEKKLQNTLA SFMDSDHCPT EKLSYLVKFK PLMELCPRIK VKVLENQQIL
550
551
LLEIKKDIRQ LETGLELLPK ILHVEALNNI PPISARISYF LNVQSRIDNI
600
601
VQYLEALFGS NWNDTLEGRS ISTSIVQLRK ETNPHDVFLH WLGNFPEKAT
650
651
ANLLTTPILK LIRNNEDDYE LKVNFDFALA AAYSELRSLT YMAFQVPSHI
700
701
VRIARTYMYL YPRAINLVEL IQTFFSLSKS LSYTFYTNIF LKRNVQTVWL
750
751
LLQQILITPW ESLQEESSEM SCSVHSLARL EKSIDGILSD YQILKNSEPQ
800
801
FAKEFSGLKS FDGTADDLHE VEEIISNIQA IFENLFTKGL TNVSDHISTF
850
851
NNLIISIILE KVRLNLKKMH FPKHVLKLSF NEGRITSSPS LAAMKRSLLK
900
901
DIEALLNKVV LINFLHDPDH PLSTTLTFNS LVIKLKDDIQ NCIEQVQNLH
950
951
CKINSYVKEW QKMEFLWQIT EEAFLEVVDN STQRCFGILK GLLDSQSKFD
1000
1001
LIISRNNFSK NLVLHTEDAQ RHIRSKMDSW ILYVSKHLLT IYERDARKLH
1050
1051
EDMNRDREAV EDMDINFTSL KNITVIIEAV NVNKRHLTER DIQIKLLGSV
1100
1101
MRALTKLKVR FPSHFVYIDQ LDNDFSSLRQ SLSYVEQELQ KHRVVIAKSL
1150
1151
EEGVENINNL SQSLNESWSV RKPISPTLTP PEALKILEFF NESITKLKKK
1200
1201
MHSVAAAAKM LLIPVVLNDQ LTHVVEEVKT YDLVWRSIKN LWEDVQRTFE
1250
1251
TPWCRVDVLL LQSDLANFLR RADELPRAVK QFEMYKSLFS QVNMLTSVNK
1300
1301
ILVELKDGAL KPRHWNMIFR DIGKRQIQKN LLDKLEFSLK DVMVLNLTLN
1350
1351
EILLTKIIER AQKEFVIEKS LNRIKKFWKE AQYEVIEHSS GLKLVREWDV
1400
1401
LEQACKEDLE ELVSMKASNY YKIFEQDCLD LESKLTKLSE IQVNWVEVQF
1450
1451
YWLDLYGILG ENLDIQNFLP LETSKFKSLT SEYKMITTRA FQLDTTIEVI
1500
1501
HIPNFDTTLK LTIDSLKMIK SSLSTFLERQ RRQFPRFYFL GNDDLLKIIG
1550
1551
SGKHHDQVSK FMKKMFGSIE SIIFLEDFIT GVRSVEGEVL NLNEKIELKD
1600
1601
SIQAQEWLNI LDTEIKLSVF TQFRDCLGQL KDGTDIEVVV SKYIFQAILL
1650
1651
SAQVMWTELV EKCLQTNQFS KYWKEVDMKI KGLLDKLNKS SDNVKKKIEA
1700
1701
LLVEYLHFNN VIGQLKNCST KEEARLLWAK VQKFYQKNDT LDDLNSVFIS
1750
1751
QSGYLLQYKF EYIGIPERLI YTPLLLIGFA TLTDSLHQKY GGCFFGPAGT
1800
1801
GKTETVKAFG QNLGRVVVVF NCDDSFDYQV LSRLLVGITQ IGAWGCFDEF
1850
1851
NRLDEKVLSA VSANIQQIQN GLQVGKSHIT LLEEETPLSP HTAVFITLNP
1900
1901
GYNGRSELPE NLKKSFREFS MKSPQSGTIA EMILQIMGFE DSKSLASKIV
1950
1951
HFLELLSSKC SSMNHYHFGL RTLKGVLRNC SPLISEFGEG EKTVVESLKR
2000
2001
VILPSLGDTD ELVFKDELSK IFDSAGTPLN SKAIVQCLKD AGQRSGFSMS
2050
2051
EEFLKKCMQF YYMQKTQQAL ILVGKAGCGK TATWKTVIDA MAIFDGHANV
2100
2101
VYVIDTKVLT KESLYGSMLK ATLEWRDGLF TSILRRVNDD ITGTFKNSRI
2150
2151
WVVFDSDLDP EYVEAMNSVL DDNKILTLPN GERLPIPPNF RILFETDNLD
2200
2201
HTTPATITRC GLLWFSTDVC SISSKIDHLL NKSYEALDNK LSMFELDKLK
2250
2251
DLISDSFDMA SLTNIFTCSN DLVHILGVRT FNKLETAVQL AVHLISSYRQ
2300
2301
WFQNLDDKSL KDVITLLIKR SLLYALAGDS TGESQRAFIQ TINTYFGHDS
2350
2351
QELSDYSTIV IANDKLSFSS FCSEIPSVSL EAHEVMRPDI VIPTIDTIKH
2400
2401
EKIFYDLLNS KRGIILCGPP GSGKTMIMNN ALRNSSLYDV VGINFSKDTT
2450
2451
TEHILSALHR HTNYVTTSKG LTLLPKSDIK NLVLFCDEIN LPKLDKYGSQ
2500
2501
NVVLFLRQLM EKQGFWKTPE NKWVTIERIH IVGACNPPTD PGRIPMSERF
2550
2551
TRHAAILYLG YPSGKSLSQI YEIYYKAIFK LVPEFRSYTE PFARASVHLY
2600
2601
NECKARYSTG LQSHYLFSPR ELTRLVRGVY TAINTGPRQT LRSLIRLWAY
2650
2651
EAWRIFADRL VGVKEKNSFE QLLYETVDKY LPNQDLGNIS STSLLFSGLL
2700
2701
SLDFKEVNKT DLVNFIEERF KTFCDEELEV PMVIHESMVD HILRIDRALK
2750
2751
QVQGHMMLIG ASRTGKTILT RFVAWLNGLK IVQPKIHRHS NLSDFDMILK
2800
2801
KAISDCSLKE SRTCLIIDES NILETAFLER MNTLLANADI PDLFQGEEYD
2850
2851
KLLNNLRNKT RSLGLLLDTE QELYDWFVGE IAKNLHVVFT ICDPTNNKSS
2900
2901
AMISSPALFN RCIINWMGDW DTKTMSQVAN NMVDVIPMEF TDFIVPEVNK
2950
2951
ELVFTEPIQT IRDAVVNILI HFDRNFYQKM KVGVNPRSPG YFIDGLRALV
3000
3001
KLVTAKYQDL QENQRFVNVG LEKLNESVLK VNELNKTLSK KSTELTEKEK
3050
3051
EARSTLDKML MEQNESERKQ EATEEIKKIL KVQEEDIRKR KEVVMKSIQD
3100
3101
IEPTILEAQR GVKNIKKQQL TEIRSMVNPP SGVKIVMEAV CAILGYQFSN
3150
3151
WRDIQQFIRK DDFIHNIVHY DTTLHMKPQI RKYMEEEFLS DPNFTYETIN
3200
3201
RASKACGPLY QWVNAQINFS KVLENVDPLR QEMKRIEFES LKTKANLLAA
3250
3251
EEMTQDLEAS IEVSKRKYSL LIRDVEAIKT EMSNVQANLD RSISLVKSLT
3300
3301
FEKERWLNTT KQFSKTSQEL IGNCIISSIY ETYFGHLNER ERADMLVILK
3350
3351
RLLGKFAVKY DVNYRFIDYL VTLDEKMKWL ECGLDKNDYF LENMSIVMNS
3400
3401
QDAVPFLLDP SSHMITVISN YYGNKTVLLS FLEEGFVKRL ENAIRFGSVV
3450
3451
IIQDGEFFDP IISRLISREF NHAGNRVTVE IGDHEVDVSG DFKLFIHSCD
3500
3501
PSGDIPIFLR SRVRLVHFVT NKESIETRIF DITLTEENAE MQRKREDLIK
3550
3551
LNTEYKLKLK NLEKRLLEEL NNSQGNMLEN DELMVTLNNL KKEAMNIEKK
3600
3601
LSESEEFFPQ FDNLVEEYSI IGKHSVKIFS MLEKFGQFHW FYGISIGQFL
3650
3651
SCFKRVFIKK SRETRAARTR VDEILWLLYQ EVYCQFSTAL DKKFKMIMAM
3700
3701
TMFCLYKFDI ESEQYKEAVL TMIGVLSESS DGVPKLTVDT NNDLRYLWDY
3750
3751
VTTKSYISAL NWFKNEFFVD EWNIADVVAN SENNYFTMAS ERDVDGTFKL
3800
3801
IELAKASKES LKIIPLGSIE NLNYAQEEIS KSKIEGGWIL LQNIQMSLSW
3850
3851
VKTYLHKHVE ETKAAEEHEK FKMFMTCHLT GDKLPAPLLQ RTDRFVYEDI
3900
3901
PGILDTVKDL WGSQFFTGKI SGVWSVYCTF LLSWFHALIT ARTRLVPHGF
3950
3951
SKKYYFNDCD FQFASVYLEN VLATNSTNNI PWAQVRDHIA TIVYGGKIDE
4000
4001
EKDLEVVAKL CAHVFCGSDN LQIVPGVRIP QPLLQQSEEE ERARLTAILS
4050
4051
NTIEPADSLS SWLQLPRESI LNYERLQAKE VASSTEQLLQ EM        
4092
 

Show the unformatted sequence.

Checksums:
CRC64:3D9DF447E8E2D6BB
MD5:60f130dcbf415239d2d6056f071f6573

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AAA_5 2069 - 2210 3QMZ A 2069 - 2210 Jmol AstexViewer SPICE
B 2069 - 2210 Jmol AstexViewer SPICE
4AI6 A 2069 - 2210 Jmol AstexViewer SPICE
B 2069 - 2210 Jmol AstexViewer SPICE
4AKG A 2069 - 2210 Jmol AstexViewer SPICE
B 2069 - 2210 Jmol AstexViewer SPICE
4AKH A 2069 - 2210 Jmol AstexViewer SPICE
B 2069 - 2210 Jmol AstexViewer SPICE
4AKI A 2069 - 2210 Jmol AstexViewer SPICE
B 2069 - 2210 Jmol AstexViewer SPICE
AAA_6 1758 - 1985 4AI6 A 1758 - 1985 Jmol AstexViewer SPICE
B 1758 - 1985 Jmol AstexViewer SPICE
4AKG A 1758 - 1985 Jmol AstexViewer SPICE
B 1758 - 1985 Jmol AstexViewer SPICE
4AKH A 1758 - 1985 Jmol AstexViewer SPICE
B 1758 - 1985 Jmol AstexViewer SPICE
4AKI A 1758 - 1985 Jmol AstexViewer SPICE
B 1758 - 1985 Jmol AstexViewer SPICE
1774 - 1985 3QMZ A 1755 - 1985 Jmol AstexViewer SPICE
B 1755 - 1985 Jmol AstexViewer SPICE
AAA_7 2381 - 2651 3QMZ A 2381 - 2651 Jmol AstexViewer SPICE
B 2381 - 2651 Jmol AstexViewer SPICE
4AI6 A 2381 - 2651 Jmol AstexViewer SPICE
B 2381 - 2651 Jmol AstexViewer SPICE
4AKG A 2381 - 2651 Jmol AstexViewer SPICE
B 2381 - 2651 Jmol AstexViewer SPICE
4AKH A 2381 - 2651 Jmol AstexViewer SPICE
B 2381 - 2651 Jmol AstexViewer SPICE
4AKI A 2381 - 2651 Jmol AstexViewer SPICE
B 2381 - 2651 Jmol AstexViewer SPICE
AAA_8 2726 - 2943 4AI6 A 2726 - 2943 Jmol AstexViewer SPICE
B 2726 - 2943 Jmol AstexViewer SPICE
4AKG A 2726 - 2943 Jmol AstexViewer SPICE
B 2726 - 2943 Jmol AstexViewer SPICE
4AKH A 2726 - 2943 Jmol AstexViewer SPICE
B 2726 - 2943 Jmol AstexViewer SPICE
4AKI A 2726 - 2943 Jmol AstexViewer SPICE
B 2726 - 2943 Jmol AstexViewer SPICE
2726 - 2956 3QMZ A 2726 - 2956 Jmol AstexViewer SPICE
B 2726 - 2956 Jmol AstexViewer SPICE
AAA_9 3370 - 3598 3QMZ A 3370 - 3598 Jmol AstexViewer SPICE
B 3370 - 3598 Jmol AstexViewer SPICE
4AI6 A 3370 - 3598 Jmol AstexViewer SPICE
B 3370 - 3598 Jmol AstexViewer SPICE
4AKG A 3370 - 3598 Jmol AstexViewer SPICE
B 3370 - 3598 Jmol AstexViewer SPICE
4AKH A 3370 - 3598 Jmol AstexViewer SPICE
B 3370 - 3598 Jmol AstexViewer SPICE
4AKI A 3370 - 3598 Jmol AstexViewer SPICE
B 3370 - 3598 Jmol AstexViewer SPICE
DHC_N2 1364 - 1631 3QMZ A 1364 - 1631 Jmol AstexViewer SPICE
B 1364 - 1631 Jmol AstexViewer SPICE
1365 - 1631 4AI6 A 1365 - 1631 Jmol AstexViewer SPICE
B 1365 - 1631 Jmol AstexViewer SPICE
4AKG A 1365 - 1631 Jmol AstexViewer SPICE
B 1365 - 1631 Jmol AstexViewer SPICE
4AKH A 1365 - 1631 Jmol AstexViewer SPICE
B 1365 - 1631 Jmol AstexViewer SPICE
4AKI A 1365 - 1631 Jmol AstexViewer SPICE
B 1365 - 1631 Jmol AstexViewer SPICE
Dynein_heavy 3753 - 4032 3QMZ A 3753 - 4032 Jmol AstexViewer SPICE
B 3753 - 4032 Jmol AstexViewer SPICE
4AI6 A 3753 - 4032 Jmol AstexViewer SPICE
B 3753 - 4032 Jmol AstexViewer SPICE
4AKG A 3753 - 4032 Jmol AstexViewer SPICE
B 3753 - 4032 Jmol AstexViewer SPICE
4AKH A 3753 - 4032 Jmol AstexViewer SPICE
B 3753 - 4032 Jmol AstexViewer SPICE
4AKI A 3753 - 4032 Jmol AstexViewer SPICE
B 3753 - 4032 Jmol AstexViewer SPICE
MT 3014 - 3352 3QMZ A 3014 - 3352 Jmol AstexViewer SPICE
B 3014 - 3352 Jmol AstexViewer SPICE
4AI6 A 3014 - 3352 Jmol AstexViewer SPICE
B 3014 - 3352 Jmol AstexViewer SPICE
4AKG A 3014 - 3352 Jmol AstexViewer SPICE
B 3014 - 3352 Jmol AstexViewer SPICE
4AKH A 3014 - 3352 Jmol AstexViewer SPICE
B 3014 - 3352 Jmol AstexViewer SPICE
4AKI A 3014 - 3352 Jmol AstexViewer SPICE
B 3014 - 3352 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.