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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TGFR1_HUMAN (P36897)

Summary

This is the summary of UniProt entry TGFR1_HUMAN (P36897).

Description: TGF-beta receptor type-1 EC=2.7.11.30
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 503 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 33
low_complexity n/a 3 34
Pfam A Activin_recp 34 114
transmembrane n/a 126 147
Pfam A TGF_beta_GS 175 203
Pfam A Pkinase 205 492

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P36897. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEAAVAAPRP RLLLLVLAAA AAAAAALLPG ATALQCFCHL CTKDNFTCVT
50
51
DGLCFVSVTE TTDKVIHNSM CIAEIDLIPR DRPFVCAPSS KTGSVTTTYC
100
101
CNQDHCNKIE LPTTVKSSPG LGPVELAAVI AGPVCFVCIS LMLMVYICHN
150
151
RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT
200
201
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ
250
251
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE
300
301
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA
350
351
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD
400
401
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL
450
451
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG
500
501
IKM                                                   
503
 

Show the unformatted sequence.

Checksums:
CRC64:179F11404725DDCB
MD5:2f7226008705915f13913ac61a9faa99

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Activin_recp 34 - 108 3KFD J 10 - 84 Jmol AstexViewer SPICE
L 10 - 84 Jmol AstexViewer SPICE
34 - 109 3KFD I 10 - 85 Jmol AstexViewer SPICE
K 10 - 85 Jmol AstexViewer SPICE
34 - 111 2PJY C 10 - 87 Jmol AstexViewer SPICE
34 - 114 2L5S A 10 - 90 Jmol AstexViewer SPICE
Pkinase 205 - 492 1B6C B 205 - 492 Jmol AstexViewer SPICE
D 205 - 492 Jmol AstexViewer SPICE
F 205 - 492 Jmol AstexViewer SPICE
H 205 - 492 Jmol AstexViewer SPICE
1IAS A 205 - 492 Jmol AstexViewer SPICE
B 205 - 492 Jmol AstexViewer SPICE
C 205 - 492 Jmol AstexViewer SPICE
D 205 - 492 Jmol AstexViewer SPICE
E 205 - 492 Jmol AstexViewer SPICE
1PY5 A 205 - 492 Jmol AstexViewer SPICE
1RW8 A 205 - 492 Jmol AstexViewer SPICE
1VJY A 205 - 492 Jmol AstexViewer SPICE
2WOT A 205 - 492 Jmol AstexViewer SPICE
2WOU A 205 - 492 Jmol AstexViewer SPICE
2X7O A 205 - 492 Jmol AstexViewer SPICE
B 205 - 492 Jmol AstexViewer SPICE
C 205 - 492 Jmol AstexViewer SPICE
D 205 - 492 Jmol AstexViewer SPICE
E 205 - 492 Jmol AstexViewer SPICE
3FAA A 205 - 492 Jmol AstexViewer SPICE
B 205 - 492 Jmol AstexViewer SPICE
C 205 - 492 Jmol AstexViewer SPICE
D 205 - 492 Jmol AstexViewer SPICE
E 205 - 492 Jmol AstexViewer SPICE
3GXL A 5 - 292 Jmol AstexViewer SPICE
3HMM A 5 - 292 Jmol AstexViewer SPICE
3KCF A 205 - 492 Jmol AstexViewer SPICE
B 205 - 492 Jmol AstexViewer SPICE
C 205 - 492 Jmol AstexViewer SPICE
D 205 - 492 Jmol AstexViewer SPICE
E 205 - 492 Jmol AstexViewer SPICE
3TZM A 205 - 492 Jmol AstexViewer SPICE
TGF_beta_GS 175 - 203 1B6C B 175 - 203 Jmol AstexViewer SPICE
D 175 - 203 Jmol AstexViewer SPICE
F 175 - 203 Jmol AstexViewer SPICE
H 175 - 203 Jmol AstexViewer SPICE
1IAS A 175 - 203 Jmol AstexViewer SPICE
B 175 - 203 Jmol AstexViewer SPICE
C 175 - 203 Jmol AstexViewer SPICE
D 175 - 203 Jmol AstexViewer SPICE
E 175 - 203 Jmol AstexViewer SPICE
2X7O A 175 - 203 Jmol AstexViewer SPICE
B 175 - 203 Jmol AstexViewer SPICE
C 175 - 203 Jmol AstexViewer SPICE
D 175 - 203 Jmol AstexViewer SPICE
E 175 - 203 Jmol AstexViewer SPICE
3FAA A 175 - 203 Jmol AstexViewer SPICE
B 175 - 203 Jmol AstexViewer SPICE
C 175 - 203 Jmol AstexViewer SPICE
D 175 - 203 Jmol AstexViewer SPICE
E 175 - 203 Jmol AstexViewer SPICE
3KCF A 175 - 203 Jmol AstexViewer SPICE
B 175 - 203 Jmol AstexViewer SPICE
C 175 - 203 Jmol AstexViewer SPICE
D 175 - 203 Jmol AstexViewer SPICE
E 175 - 203 Jmol AstexViewer SPICE
200 - 203 1PY5 A 200 - 203 Jmol AstexViewer SPICE
1RW8 A 200 - 203 Jmol AstexViewer SPICE
2WOT A 200 - 203 Jmol AstexViewer SPICE
2WOU A 200 - 203 Jmol AstexViewer SPICE
3TZM A 200 - 203 Jmol AstexViewer SPICE
201 - 203 1VJY A 201 - 203 Jmol AstexViewer SPICE
3GXL A 1 - 3 Jmol AstexViewer SPICE
3HMM A 1 - 3 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.