Summary
This is the summary of UniProt entry SRBP1_HUMAN (P36956).
| Description: | Sterol regulatory element-binding protein 1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1147 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 24 |
| disorder | n/a | 26 | 197 |
| low_complexity | n/a | 62 | 82 |
| low_complexity | n/a | 87 | 107 |
| low_complexity | n/a | 143 | 159 |
| low_complexity | n/a | 164 | 179 |
| low_complexity | n/a | 184 | 201 |
| disorder | n/a | 199 | 203 |
| low_complexity | n/a | 215 | 238 |
| disorder | n/a | 219 | 221 |
| disorder | n/a | 224 | 227 |
| disorder | n/a | 311 | 331 |
| Pfam A | HLH | 324 | 374 |
| disorder | n/a | 383 | 388 |
| disorder | n/a | 412 | 413 |
| disorder | n/a | 415 | 479 |
| low_complexity | n/a | 438 | 461 |
| transmembrane | n/a | 488 | 509 |
| disorder | n/a | 515 | 528 |
| low_complexity | n/a | 544 | 566 |
| transmembrane | n/a | 548 | 567 |
| Pfam B | Pfam-B_7446 | 561 | 1133 |
| low_complexity | n/a | 599 | 612 |
| low_complexity | n/a | 657 | 672 |
| low_complexity | n/a | 690 | 703 |
| disorder | n/a | 820 | 828 |
| low_complexity | n/a | 987 | 998 |
| disorder | n/a | 988 | 1009 |
| disorder | n/a | 1047 | 1049 |
| disorder | n/a | 1051 | 1065 |
| low_complexity | n/a | 1062 | 1075 |
| disorder | n/a | 1067 | 1083 |
| disorder | n/a | 1088 | 1089 |
| disorder | n/a | 1113 | 1115 |
| disorder | n/a | 1139 | 1140 |
| disorder | n/a | 1142 | 1147 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P36956. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP
50 51
YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP
100 101
QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP
150 151
APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS
200 201
LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL
250 251
LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
300 301
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV
350 351
VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL
400 401
VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS
450 451
GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR GMLDRSRLAL CTLVFLCLSC
500 501
NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW AQWLLPPVVW
550 551
LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
600 601
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG
650 651
GLQQDCALRV DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL
700 701
NLAECAGDAV SVATLAEIYV AAALRVKTSL PRALHFLTRF FLSSARQACL
750 751
AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL STPWESLYSL AGNPVDPLAQ
800 801
VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL QLLNSCSDAA
850 851
GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
900 901
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG
950 951
YLQDSLATTP ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT
1000 1001
SSRPQASALE LRGFQRDLSS LRRLAQSFRP AMRRVFLHEA TARLMAGASP
1050 1051
TRTHQLLDRS LRRRAGPGGK GGAVAELEPR PTRREHAEAL LLASCYLPPG
1100 1101
FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG GTTVTSS
1147
Show the unformatted sequence. |
| Checksums: |
CRC64:58F28870739FF259
MD5:4bdd3c4cd29f4507d5ceabcace081885
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| HLH | 324 - 374 | 1AM9 | A | 324 - 374 | Jmol AstexViewer SPICE |
| B | 324 - 374 | Jmol AstexViewer SPICE | |||
| C | 324 - 374 | Jmol AstexViewer SPICE | |||
| D | 324 - 374 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.