Summary
This is the summary of UniProt entry TPO_HUMAN (P40225).
| Description: | Thrombopoietin |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 353 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 21 |
| low_complexity | n/a | 1 | 15 |
| Pfam A | EPO_TPO | 24 | 188 |
| low_complexity | n/a | 107 | 133 |
| disorder | n/a | 133 | 137 |
| disorder | n/a | 176 | 177 |
| disorder | n/a | 185 | 188 |
| disorder | n/a | 201 | 207 |
| disorder | n/a | 257 | 312 |
| low_complexity | n/a | 305 | 342 |
| disorder | n/a | 315 | 353 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P40225. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC
50 51
PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG
100 101
QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQLPPQGRTT AHKDPNAIFL
150 151
SFQHLLRGKV RFLMLVGGST LCVRRAPPTT AVPSRTSLVL TLNELPNRTS
200 201
GLLETNFTAS ARTTGSGLLK WQQGFRAKIP GLLNQTSRSL DQIPGYLNRI
250 251
HELLNGTRGL FPGPSRRTLG APDISSGTSD TGSLPPNLQP GYSPSPTHPP
300 301
TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN TSYTHSQNLS
350 351
QEG
353
Show the unformatted sequence. |
| Checksums: |
CRC64:F0AB5449B72E5526
MD5:095bd0b9a87f787dfd7088079eb1d3f5
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| EPO_TPO | 28 - 172 | 1V7M | V | 7 - 151 | Jmol AstexViewer SPICE |
| X | 7 - 151 | Jmol AstexViewer SPICE | |||
| 1V7N | V | 7 - 151 | Jmol AstexViewer SPICE | ||
| 29 - 166 | 1V7N | X | 8 - 145 | Jmol AstexViewer SPICE | |
| 29 - 167 | 1V7N | Y | 8 - 146 | Jmol AstexViewer SPICE | |
| 30 - 167 | 1V7N | Z | 9 - 146 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.