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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MK08_HUMAN (P45983)

Summary

This is the summary of UniProt entry MK08_HUMAN (P45983).

Description: Mitogen-activated protein kinase 8 EC=2.7.11.24
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 427 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Pkinase 26 321
disorder n/a 327 345
disorder n/a 366 423
low_complexity n/a 387 403

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P45983. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER
50
51
NVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE
100
101
FQDVYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR
150
151
DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM
200
201
GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ LGTPCPEFMK
250
251
KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK
300
301
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE
350
351
EWKELIYKEV MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS
400
401
SMSTDPTLAS DTDSSLEAAA GPLGCCR                         
427
 

Show the unformatted sequence.

Checksums:
CRC64:94FB6BE0358B9B60
MD5:b89f0ae73bbb390fff82f35e5b453aa1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 26 - 321 1UKH A 26 - 321 Jmol AstexViewer SPICE
1UKI A 26 - 321 Jmol AstexViewer SPICE
2G01 A 26 - 321 Jmol AstexViewer SPICE
B 26 - 321 Jmol AstexViewer SPICE
2GMX A 26 - 321 Jmol AstexViewer SPICE
B 26 - 321 Jmol AstexViewer SPICE
2H96 A 26 - 321 Jmol AstexViewer SPICE
B 26 - 321 Jmol AstexViewer SPICE
2NO3 A 26 - 321 Jmol AstexViewer SPICE
B 26 - 321 Jmol AstexViewer SPICE
2XRW A 26 - 321 Jmol AstexViewer SPICE
2XS0 A 26 - 321 Jmol AstexViewer SPICE
3ELJ A 26 - 321 Jmol AstexViewer SPICE
3O17 A 26 - 321 Jmol AstexViewer SPICE
B 26 - 321 Jmol AstexViewer SPICE
3O2M A 26 - 321 Jmol AstexViewer SPICE
B 26 - 321 Jmol AstexViewer SPICE
3PZE A 26 - 321 Jmol AstexViewer SPICE