Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
21  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MK14_MOUSE (P47811)

Summary

This is the summary of UniProt entry MK14_MOUSE (P47811).

Description: Mitogen-activated protein kinase 14 EC=2.7.11.24
Source organism: Mus musculus (Mouse)
Length: 360 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Pkinase 24 308
low_complexity n/a 299 312
disorder n/a 319 322
disorder n/a 356 360

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P47811. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGHRV
50
51
AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN
100
101
DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD
150
151
LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY
200
201
NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG TPGAELLKKI
250
251
SSESARNYIQ SLAQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
300
301
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP
350
351
PPLDQEEMES                                            
360
 

Show the unformatted sequence.

Checksums:
CRC64:DFB03EBCE97BB51A
MD5:b1d4ee6fd1f9fa0c828123d074babf5e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 24 - 308 1LEW A 24 - 308 Jmol AstexViewer SPICE
1LEZ A 24 - 308 Jmol AstexViewer SPICE
1P38 A 24 - 308 Jmol AstexViewer SPICE
1YW2 A 1024 - 1308 Jmol AstexViewer SPICE
1YWR A 24 - 308 Jmol AstexViewer SPICE
2EWA A 24 - 308 Jmol AstexViewer SPICE
2GHL A 24 - 308 Jmol AstexViewer SPICE
2GHM A 24 - 308 Jmol AstexViewer SPICE
2GTM A 24 - 308 Jmol AstexViewer SPICE
2GTN A 24 - 308 Jmol AstexViewer SPICE
2OZA B 24 - 308 Jmol AstexViewer SPICE
2PUU A 24 - 308 Jmol AstexViewer SPICE
3P4K A 24 - 308 Jmol AstexViewer SPICE
3P5K A 24 - 308 Jmol AstexViewer SPICE
3P78 A 24 - 308 Jmol AstexViewer SPICE
3P79 A 24 - 308 Jmol AstexViewer SPICE
3P7A A 24 - 308 Jmol AstexViewer SPICE
3P7B A 24 - 308 Jmol AstexViewer SPICE
3P7C A 24 - 308 Jmol AstexViewer SPICE
3PY3 A 24 - 308 Jmol AstexViewer SPICE
3TG1 A 24 - 308 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.