Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RBP2_HUMAN (P49792)

Summary

This is the summary of UniProt entry RBP2_HUMAN (P49792).

Description: E3 SUMO-protein ligase RanBP2 Putative peptidyl-prolyl cis-trans isomerase EC=6.3.2.- EC=5.2.1.8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 3224 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A TPR_1 60 93
low_complexity n/a 235 247
Pfam B Pfam-B_140158 307 382
Pfam B Pfam-B_7383 384 574
low_complexity n/a 607 619
disorder n/a 697 706
coiled_coil n/a 739 759
disorder n/a 760 792
low_complexity n/a 785 801
disorder n/a 795 802
Pfam B Pfam-B_1048 796 833
coiled_coil n/a 811 831
disorder n/a 825 864
Pfam B Pfam-B_39104 869 1057
disorder n/a 888 891
disorder n/a 898 905
disorder n/a 907 909
disorder n/a 913 921
disorder n/a 926 932
disorder n/a 945 952
disorder n/a 957 970
disorder n/a 972 989
disorder n/a 991 995
disorder n/a 997 1039
disorder n/a 1044 1130
disorder n/a 1136 1140
disorder n/a 1142 1184
low_complexity n/a 1157 1169
Pfam A Ran_BP1 1183 1304
disorder n/a 1316 1323
Pfam A zf-RanBP 1351 1381
disorder n/a 1389 1398
disorder n/a 1405 1409
Pfam A zf-RanBP 1415 1444
disorder n/a 1470 1471
Pfam A zf-RanBP 1479 1508
disorder n/a 1513 1515
disorder n/a 1534 1535
Pfam A zf-RanBP 1543 1572
low_complexity n/a 1572 1583
disorder n/a 1577 1587
disorder n/a 1596 1600
Pfam A zf-RanBP 1606 1635
disorder n/a 1637 1659
Pfam A zf-RanBP 1665 1694
disorder n/a 1697 1718
Pfam A zf-RanBP 1724 1753
disorder n/a 1760 1767
Pfam A zf-RanBP 1781 1810
disorder n/a 1815 1821
disorder n/a 1825 1826
disorder n/a 1832 1833
disorder n/a 1856 1860
disorder n/a 1872 1877
disorder n/a 1885 1886
disorder n/a 1900 1933
disorder n/a 1990 1992
disorder n/a 1994 2001
disorder n/a 2009 2011
Pfam A Ran_BP1 2024 2145
disorder n/a 2160 2164
disorder n/a 2188 2231
low_complexity n/a 2198 2210
low_complexity n/a 2232 2253
disorder n/a 2235 2246
disorder n/a 2254 2255
low_complexity n/a 2269 2284
disorder n/a 2271 2272
disorder n/a 2278 2308
low_complexity n/a 2311 2322
Pfam A Ran_BP1 2321 2442
disorder n/a 2447 2457
disorder n/a 2459 2460
disorder n/a 2464 2470
disorder n/a 2479 2504
low_complexity n/a 2492 2504
disorder n/a 2508 2509
disorder n/a 2556 2584
disorder n/a 2611 2635
low_complexity n/a 2614 2631
Pfam A IR1-M 2631 2695
disorder n/a 2664 2665
disorder n/a 2669 2678
low_complexity n/a 2669 2678
disorder n/a 2695 2701
disorder n/a 2707 2708
Pfam A IR1-M 2709 2771
disorder n/a 2710 2711
disorder n/a 2723 2725
disorder n/a 2747 2779
disorder n/a 2785 2787
disorder n/a 2790 2791
disorder n/a 2796 2837
low_complexity n/a 2798 2810
low_complexity n/a 2839 2850
disorder n/a 2884 2906
low_complexity n/a 2891 2905
low_complexity n/a 2920 2931
Pfam A Ran_BP1 2922 3043
Pfam A Pro_isomerase 3067 3223
disorder n/a 3159 3161

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49792. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRRSKADVER YIASVQGSTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC
50
51
TYINVQERDP KAHRFLGLLY ELEENTDKAV ECYRRSVELN PTQKDLVLKI
100
101
AELLCKNDVT DGRAKYWLER AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL
150
151
FDLIQSELYV RPDDVHVNIR LVEVYRSTKR LKDAVAHCHE AERNIALRSS
200
201
LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA NLMLLTLSTR
250
251
DVQESRELLQ SFDSALQSVK SLGGNDELSA TFLEMKGHFY MHAGSLLLKM
300
301
GQHSSNVQWR ALSELAALCY LIAFQVPRPK IKLIKGEAGQ NLLEMMACDR
350
351
LSQSGHMLLN LSRGKQDFLK EIVETFANKS GQSALYDALF SSQSPKDTSF
400
401
LGSDDIGNID VREPELEDLT RYDVGAIRAH NGSLQHLTWL GLQWNSLPAL
450
451
PGIRKWLKQL FHHLPHETSR LETNAPESIC ILDLEVFLLG VVYTSHLQLK
500
501
EKCNSHHSSY QPLCLPLPVC KQLCTERQKS WWDAVCTLIH RKAVPGNVAK
550
551
LRLLVQHEIN TLRAQEKHGL QPALLVHWAE CLQKTGSGLN SFYDQREYIG
600
601
RSVHYWKKVL PLLKIIKKKN SIPEPIDPLF KHFHSVDIQA SEIVEYEEDA
650
651
HITFAILDAV NGNIEDAVTA FESIKSVVSY WNLALIFHRK AEDIENDALS
700
701
PEEQEECKNY LRKTRDYLIK IIDDSDSNLS VVKKLPVPLE SVKEMLNSVM
750
751
QELEDYSEGG PLYKNGSLRN ADSEIKHSTP SPTRYSLSPS KSYKYSPKTP
800
801
PRWAEDQNSL LKMICQQVEA IKKEMQELKL NSSNSASPHR WPTENYGPDS
850
851
VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG
900
901
PVYGMNRLPP QQHIYAYPQQ MHTPPVQSSS ACMFSQEMYG PPALRFESPA
950
951
TGILSPRGDD YFNYNVQQTS TNPPLPEPGY FTKPPIAAHA SRSAESKTIE
1000
1001
FGKTNFVQPM PGEGLRPSLP TQAHTTQPTP FKFNSNFKSN DGDFTFSSPQ
1050
1051
VVTQPPPAAY SNSESLLGLL TSDKPLQGDG YSGAKPIPGG QTIGPRNTFN
1100
1101
FGSKNVSGIS FTENMGSSQQ KNSGFRRSDD MFTFHGPGKS VFGTPTLETA
1150
1151
NKNHETDGGS AHGDDDDDGP HFEPVVPLPD KIEVKTGEED EEEFFCNRAK
1200
1201
LFRFDVESKE WKERGIGNVK ILRHKTSGKI RLLMRREQVL KICANHYISP
1250
1251
DMKLTPNAGS DRSFVWHALD YADELPKPEQ LAIRFKTPEE AALFKCKFEE
1300
1301
AQSILKAPGT NVAMASNQAV RIVKEPTSHD NKDICKSDAG NLNFEFQVAK
1350
1351
KEGSWWHCNS CSLKNASTAK KCVSCQNLNP SNKELVGPPL AETVFTPKTS
1400
1401
PENVQDRFAL VTPKKEGHWD CSICLVRNEP TVSRCIACQN TKSANKSGSS
1450
1451
FVHQASFKFG QGDLPKPINS DFRSVFSTKE GQWDCSACLV QNEGSSTKCA
1500
1501
ACQNPRKQSL PATSIPTPAS FKFGTSETSK TLKSGFEDMF AKKEGQWDCS
1550
1551
SCLVRNEANA TRCVACQNPD KPSPSTSVPA PASFKFGTSE TSKAPKSGFE
1600
1601
GMFTKKEGQW DCSVCLVRNE ASATKCIACQ NPGKQNQTTS AVSTPASSET
1650
1651
SKAPKSGFEG MFTKKEGQWD CSVCLVRNEA SATKCIACQN PGKQNQTTSA
1700
1701
VSTPASSETS KAPKSGFEGM FTKKEGQWDC SVCLVRNEAS ATKCIACQCP
1750
1751
SKQNQTTAIS TPASSEISKA PKSGFEGMFI RKGQWDCSVC CVQNESSSLK
1800
1801
CVACDASKPT HKPIAEAPSA FTLGSEMKLH DSSGSQVGTG FKSNFSEKAS
1850
1851
KFGNTEQGFK FGHVDQENSP SFMFQGSSNT EFKSTKEGFS IPVSADGFKF
1900
1901
GISEPGNQEK KSEKPLENGT GFQAQDISGQ KNGRGVIFGQ TSSTFTFADL
1950
1951
AKSTSGEGFQ FGKKDPNFKG FSGAGEKLFS SQYGKMANKA NTSGDFEKDD
2000
2001
DAYKTEDSDD IHFEPVVQMP EKVELVTGEE DEKVLYSQRV KLFRFDAEVS
2050
2051
QWKERGLGNL KILKNEVNGK LRMLMRREQV LKVCANHWIT TTMNLKPLSG
2100
2101
SDRAWMWLAS DFSDGDAKLE QLAAKFKTPE LAEEFKQKFE ECQRLLLDIP
2150
2151
LQTPHKLVDT GRAAKLIQRA EEMKSGLKDF KTFLTNDQTK VTEEENKGSG
2200
2201
TGAAGASDTT IKPNPENTGP TLEWDNYDLR EDALDDSVSS SSVHASPLAS
2250
2251
SPVRKNLFRF GESTTGFNFS FKSALSPSKS PAKLNQSGTS VGTDEESDVT
2300
2301
QEEERDGQYF EPVVPLPDLV EVSSGEENEQ VVFSHRAKLY RYDKDVGQWK
2350
2351
ERGIGDIKIL QNYDNKQVRI VMRRDQVLKL CANHRITPDM TLQNMKGTER
2400
2401
VWLWTACDFA DGERKVEHLA VRFKLQDVAD SFKKIFDEAK TAQEKDSLIT
2450
2451
PHVSRSSTPR ESPCGKIAVA VLEETTRERT DVIQGDDVAD ATSEVEVSST
2500
2501
SETTPKAVVS PPKFVFGSES VKSIFSSEKS KPFAFGNSSA TGSLFGFSFN
2550
2551
APLKSNNSET SSVAQSGSES KVEPKKCELS KNSDIEQSSD SKVKNLFASF
2600
2601
PTEESSINYT FKTPEKAKEK KKPEDSPSDD DVLIVYELTP TAEQKALATK
2650
2651
LKLPPTFFCY KNRPDYVSEE EEDDEDFETA VKKLNGKLYL DGSEKCRPLE
2700
2701
ENTADNEKEC IIVWEKKPTV EEKAKADTLK LPPTFFCGVC SDTDEDNGNG
2750
2751
EDFQSELQKV QEAQKSQTEE ITSTTDSVYT GGTEVMVPSF CKSEEPDSIT
2800
2801
KSISSPSVSS ETMDKPVDLS TRKEIDTDST SQGESKIVSF GFGSSTGLSF
2850
2851
ADLASSNSGD FAFGSKDKNF QWANTGAAVF GTQSVGTQSA GKVGEDEDGS
2900
2901
DEEVVHNEDI HFEPIVSLPE VEVKSGEEDE EILFKERAKL YRWDRDVSQW
2950
2951
KERGVGDIKI LWHTMKNYYR ILMRRDQVFK VCANHVITKT MELKPLNVSN
3000
3001
NALVWTASDY ADGEAKVEQL AVRFKTKEVA DCFKKTFEEC QQNLMKLQKG
3050
3051
HVSLAAELSK ETNPVVFFDV CADGEPLGRI TMELFSNIVP RTAENFRALC
3100
3101
TGEKGFGFKN SIFHRVIPDF VCQGGDITKH DGTGGQSIYG DKFEDENFDV
3150
3151
KHTGPGLLSM ANQGQNTNNS QFVITLKKAE HLDFKHVVFG FVKDGMDTVK
3200
3201
KIESFGSPKG SVCRRITITE CGQI                            
3224
 

Show the unformatted sequence.

Checksums:
CRC64:4CD9A3D5E77183FB
MD5:27020bf5a3b214f66aacbcc4baa05398

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IR1-M 2631 - 2690 3UIP D 2631 - 2690 Jmol AstexViewer SPICE
2631 - 2693 1Z5S D 2631 - 2693 Jmol AstexViewer SPICE
3UIN D 2631 - 2693 Jmol AstexViewer SPICE
2631 - 2694 3UIO D 2631 - 2694 Jmol AstexViewer SPICE
Ran_BP1 1183 - 1304 1RRP B 29 - 150 Jmol AstexViewer SPICE
D 29 - 150 Jmol AstexViewer SPICE
2028 - 2145 1XKE A 3 - 120 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.