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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DNLI4_HUMAN (P49917)

Summary

This is the summary of UniProt entry DNLI4_HUMAN (P49917).

Description: DNA ligase 4 EC=6.5.1.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 911 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 2
Pfam A DNA_ligase_A_N 14 209
Pfam A DNA_ligase_A_M 248 451
Pfam A DNA_ligase_A_C 476 588
disorder n/a 621 629
low_complexity n/a 626 636
Pfam A BRCT 654 730
Pfam A DNA_ligase_IV 749 784
Pfam A BRCT 818 898
low_complexity n/a 875 887

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49917. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAASQTSQTV ASHVPFADLC STLERIQKSK GRAEKIRHFR EFLDSWRKFH
50
51
DALHKNHKDV TDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP
100
101
RDGKDALKLL NYRTPTGTHG DAGDFAMIAY FVLKPRCLQK GSLTIQQVND
150
151
LLDSIASNNS AKRKDLIKKS LLQLITQSSA LEQKWLIRMI IKDLKLGVSQ
200
201
QTIFSVFHND AAELHNVTTD LEKVCRQLHD PSVGLSDISI TLFSAFKPML
250
251
AAIADIEHIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYKY FSRNGYNYTD
300
301
QFGASPTEGS LTPFIHNAFK ADIQICILDG EMMAYNPNTQ TFMQKGTKFD
350
351
IKRMVEDSDL QTCYCVFDVL MVNNKKLGHE TLRKRYEILS SIFTPIPGRI
400
401
EIVQKTQAHT KNEVIDALNE AIDKREEGIM VKQPLSIYKP DKRGEGWLKI
450
451
KPEYVSGLMD ELDILIVGGY WGKGSRGGMM SHFLCAVAEK PPPGEKPSVF
500
501
HTLSRVGSGC TMKELYDLGL KLAKYWKPFH RKAPPSSILC GTEKPEVYIE
550
551
PCNSVIVQIK AAEIVPSDMY KTGCTLRFPR IEKIRDDKEW HECMTLDDLE
600
601
QLRGKASGKL ASKHLYIGGD DEPQEKKRKA APKMKKVIGI IEHLKAPNLT
650
651
NVNKISNIFE DVEFCVMSGT DSQPKPDLEN RIAEFGGYIV QNPGPDTYCV
700
701
IAGSENIRVK NIILSNKHDV VKPAWLLECF KTKSFVPWQP RFMIHMCPST
750
751
KEHFAREYDC YGDSYFIDTD LNQLKEVFSG IKNSNEQTPE EMASLIADLE
800
801
YRYSWDCSPL SMFRRHTVYL DSYAVINDLS TKNEGTRLAI KALELRFHGA
850
851
KVVSCLAEGV SHVIIGEDHS RVADFKAFRR TFKRKFKILK ESWVTDSIDK
900
901
CELQEENQYL I                                          
911
 

Show the unformatted sequence.

Checksums:
CRC64:2122813E1EFA63B9
MD5:00afcde800026581661b6cbe2d08c898

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BRCT 654 - 730 2E2W A 8 - 84 Jmol AstexViewer SPICE
3II6 X 654 - 730 Jmol AstexViewer SPICE
Y 654 - 730 Jmol AstexViewer SPICE
818 - 898 3II6 X 818 - 898 Jmol AstexViewer SPICE
Y 818 - 898 Jmol AstexViewer SPICE
DNA_ligase_A_M 268 - 406 3VNN A 268 - 406 Jmol AstexViewer SPICE
DNA_ligase_IV 749 - 759 2E2W A 103 - 113 Jmol AstexViewer SPICE
749 - 784 3II6 X 749 - 784 Jmol AstexViewer SPICE
Y 749 - 784 Jmol AstexViewer SPICE
755 - 782 1IK9 C 755 - 782 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.