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32  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MK10_HUMAN (P53779)

Summary

This is the summary of UniProt entry MK10_HUMAN (P53779).

Description: Mitogen-activated protein kinase 10 EC=2.7.11.24
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 464 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Pkinase 64 359
disorder n/a 372 382
disorder n/a 402 460
low_complexity n/a 423 432

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P53779. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS
50
51
VEVGDSTFTV LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ
100
101
NQTHAKRAYR ELVLMKCVNH KNIISLLNVF TPQKTLEEFQ DVYLVMELMD
150
151
ANLCQVIQME LDHERMSYLL YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD
200
201
CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY KENVDIWSVG
250
251
CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN
300
301
RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV
350
351
DDALQHPYIN VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN
400
401
SEEKTKNGVV KGQPSPSGAA VNSSESLPPS SSVNDISSMS TDQTLASDTD
450
451
SSLEASAGPL GCCR                                       
464
 

Show the unformatted sequence.

Checksums:
CRC64:2E20C05EB89CDA66
MD5:aa5ebc040a73c561149ab7792b896666

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 64 - 359 1JNK A 64 - 359 Jmol AstexViewer SPICE
1PMN A 64 - 359 Jmol AstexViewer SPICE
1PMQ A 64 - 359 Jmol AstexViewer SPICE
1PMU A 64 - 359 Jmol AstexViewer SPICE
1PMV A 64 - 359 Jmol AstexViewer SPICE
2B1P A 64 - 359 Jmol AstexViewer SPICE
2EXC X 64 - 359 Jmol AstexViewer SPICE
2O0U A 64 - 359 Jmol AstexViewer SPICE
2O2U A 64 - 359 Jmol AstexViewer SPICE
2OK1 A 64 - 359 Jmol AstexViewer SPICE
2P33 A 64 - 359 Jmol AstexViewer SPICE
2R9S A 64 - 359 Jmol AstexViewer SPICE
B 64 - 359 Jmol AstexViewer SPICE
2WAJ A 64 - 359 Jmol AstexViewer SPICE
2ZDT A 64 - 359 Jmol AstexViewer SPICE
2ZDU A 64 - 359 Jmol AstexViewer SPICE
3CGF A 64 - 359 Jmol AstexViewer SPICE
3CGO A 64 - 359 Jmol AstexViewer SPICE
3DA6 A 64 - 359 Jmol AstexViewer SPICE
3FI2 A 64 - 359 Jmol AstexViewer SPICE
3FI3 A 64 - 359 Jmol AstexViewer SPICE
3FV8 A 64 - 359 Jmol AstexViewer SPICE
3G90 X 64 - 359 Jmol AstexViewer SPICE
3G9L X 64 - 359 Jmol AstexViewer SPICE
3G9N A 20 - 315 Jmol AstexViewer SPICE
3KVX A 64 - 359 Jmol AstexViewer SPICE
3OXI A 64 - 359 Jmol AstexViewer SPICE
3OY1 A 64 - 359 Jmol AstexViewer SPICE
3PTG A 64 - 359 Jmol AstexViewer SPICE
3TTI A 64 - 359 Jmol AstexViewer SPICE
3TTJ A 64 - 359 Jmol AstexViewer SPICE
3V6R A 64 - 359 Jmol AstexViewer SPICE
B 64 - 359 Jmol AstexViewer SPICE
3V6S A 64 - 359 Jmol AstexViewer SPICE
B 64 - 359 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.