Summary
This is the summary of UniProt entry DPOG1_HUMAN (P54098).
| Description: | DNA polymerase subunit gamma-1 EC=2.7.7.7 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1239 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam B | Pfam-B_14078 | 1 | 69 |
| disorder | n/a | 6 | 76 |
| low_complexity | n/a | 9 | 23 |
| low_complexity | n/a | 26 | 37 |
| low_complexity | n/a | 39 | 60 |
| disorder | n/a | 80 | 82 |
| disorder | n/a | 85 | 106 |
| low_complexity | n/a | 153 | 172 |
| disorder | n/a | 246 | 253 |
| disorder | n/a | 258 | 260 |
| Pfam B | Pfam-B_2541 | 266 | 561 |
| disorder | n/a | 318 | 336 |
| disorder | n/a | 376 | 377 |
| coiled_coil | n/a | 438 | 465 |
| low_complexity | n/a | 496 | 505 |
| disorder | n/a | 506 | 536 |
| disorder | n/a | 559 | 561 |
| disorder | n/a | 563 | 564 |
| disorder | n/a | 633 | 635 |
| coiled_coil | n/a | 691 | 711 |
| disorder | n/a | 714 | 736 |
| Pfam A | DNA_pol_A | 730 | 1182 |
| disorder | n/a | 773 | 775 |
| disorder | n/a | 777 | 787 |
| disorder | n/a | 861 | 862 |
| disorder | n/a | 871 | 874 |
| disorder | n/a | 932 | 936 |
| disorder | n/a | 1204 | 1206 |
| disorder | n/a | 1234 | 1239 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P54098. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSRLLWRKVA GATVGPGPVP APGRWVSSSV PASDPSDGQR RRQQQQQQQQ
50 51
QQQQQPQQPQ VLSSEGGQLR HNPLDIQMLS RGLHEQIFGQ GGEMPGEAAV
100 101
RRSVEHLQKH GLWGQPAVPL PDVELRLPPL YGDNLDQHFR LLAQKQSLPY
150 151
LEAANLLLQA QLPPKPPAWA WAEGWTRYGP EGEAVPVAIP EERALVFDVE
200 201
VCLAEGTCPT LAVAISPSAW YSWCSQRLVE ERYSWTSQLS PADLIPLEVP
250 251
TGASSPTQRD WQEQLVVGHN VSFDRAHIRE QYLIQGSRMR FLDTMSMHMA
300 301
ISGLSSFQRS LWIAAKQGKH KVQPPTKQGQ KSQRKARRGP AISSWDWLDI
350 351
SSVNSLAEVH RLYVGGPPLE KEPRELFVKG TMKDIRENFQ DLMQYCAQDV
400 401
WATHEVFQQQ LPLFLERCPH PVTLAGMLEM GVSYLPVNQN WERYLAEAQG
450 451
TYEELQREMK KSLMDLANDA CQLLSGERYK EDPWLWDLEW DLQEFKQKKA
500 501
KKVKKEPATA SKLPIEGAGA PGDPMDQEDL GPCSEEEEFQ QDVMARACLQ
550 551
KLKGTTELLP KRPQHLPGHP GWYRKLCPRL DDPAWTPGPS LLSLQMRVTP
600 601
KLMALTWDGF PLHYSERHGW GYLVPGRRDN LAKLPTGTTL ESAGVVCPYR
650 651
AIESLYRKHC LEQGKQQLMP QEAGLAEEFL LTDNSAIWQT VEELDYLEVE
700 701
AEAKMENLRA AVPGQPLALT ARGGPKDTQP SYHHGNGPYN DVDIPGCWFF
750 751
KLPHKDGNSC NVGSPFAKDF LPKMEDGTLQ AGPGGASGPR ALEINKMISF
800 801
WRNAHKRISS QMVVWLPRSA LPRAVIRHPD YDEEGLYGAI LPQVVTAGTI
850 851
TRRAVEPTWL TASNARPDRV GSELKAMVQA PPGYTLVGAD VDSQELWIAA
900 901
VLGDAHFAGM HGCTAFGWMT LQGRKSRGTD LHSKTATTVG ISREHAKIFN
950 951
YGRIYGAGQP FAERLLMQFN HRLTQQEAAE KAQQMYAATK GLRWYRLSDE
1000 1001
GEWLVRELNL PVDRTEGGWI SLQDLRKVQR ETARKSQWKK WEVVAERAWK
1050 1051
GGTESEMFNK LESIATSDIP RTPVLGCCIS RALEPSAVQE EFMTSRVNWV
1100 1101
VQSSAVDYLH LMLVAMKWLF EEFAIDGRFC ISIHDEVRYL VREEDRYRAA
1150 1151
LALQITNLLT RCMFAYKLGL NDLPQSVAFF SAVDIDRCLR KEVTMDCKTP
1200 1201
SNPTGMERRY GIPQGEALDI YQIIELTKGS LEKRSQPGP
1239
Show the unformatted sequence. |
| Checksums: |
CRC64:2D9ECCD75AD6E01E
MD5:27a02d83e51e9e4306c2c77ce53d2c1e
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| DNA_pol_A | 730 - 1182 | 3IKM | A | 730 - 1182 | Jmol AstexViewer SPICE |
| D | 730 - 1182 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.