Summary
This is the summary of UniProt entry AFAD_HUMAN (P55196).
| Description: | Afadin |
| Source organism: |
Homo sapiens (Human) |
| Length: | 1824 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 4 |
| Pfam A | RA | 39 | 133 |
| disorder | n/a | 73 | 74 |
| disorder | n/a | 126 | 254 |
| coiled_coil | n/a | 147 | 183 |
| low_complexity | n/a | 163 | 175 |
| Pfam A | RA | 246 | 348 |
| disorder | n/a | 280 | 283 |
| disorder | n/a | 298 | 302 |
| disorder | n/a | 307 | 316 |
| disorder | n/a | 350 | 378 |
| disorder | n/a | 381 | 387 |
| disorder | n/a | 417 | 421 |
| Pfam A | FHA | 426 | 492 |
| disorder | n/a | 436 | 440 |
| disorder | n/a | 444 | 446 |
| disorder | n/a | 452 | 459 |
| disorder | n/a | 463 | 477 |
| disorder | n/a | 483 | 484 |
| disorder | n/a | 510 | 534 |
| disorder | n/a | 539 | 543 |
| disorder | n/a | 545 | 595 |
| Pfam A | DIL | 785 | 891 |
| low_complexity | n/a | 876 | 883 |
| disorder | n/a | 914 | 921 |
| disorder | n/a | 994 | 995 |
| Pfam A | PDZ | 1008 | 1090 |
| disorder | n/a | 1080 | 1082 |
| disorder | n/a | 1100 | 1101 |
| disorder | n/a | 1106 | 1557 |
| Pfam B | Pfam-B_12159 | 1152 | 1249 |
| Pfam B | Pfam-B_10625 | 1251 | 1399 |
| low_complexity | n/a | 1309 | 1318 |
| low_complexity | n/a | 1345 | 1356 |
| low_complexity | n/a | 1365 | 1372 |
| low_complexity | n/a | 1386 | 1392 |
| Pfam B | Pfam-B_9760 | 1401 | 1509 |
| coiled_coil | n/a | 1412 | 1443 |
| low_complexity | n/a | 1420 | 1440 |
| coiled_coil | n/a | 1526 | 1546 |
| disorder | n/a | 1568 | 1721 |
| low_complexity | n/a | 1577 | 1587 |
| low_complexity | n/a | 1595 | 1645 |
| coiled_coil | n/a | 1602 | 1663 |
| low_complexity | n/a | 1685 | 1713 |
| Pfam B | Pfam-B_12738 | 1701 | 1822 |
| disorder | n/a | 1725 | 1733 |
| disorder | n/a | 1736 | 1824 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P55196. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK
50 51
AAGNFATKCI RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG
100 101
ERRLDIDEKP LVVQLNWNKD DREGRFVLKN ENDAIPPKKA QSNGPEKQEK
150 151
EGVIQNFKRT LSKKEKKEKK KREKEALRQA SDKDDRPFQG EDVENSRLAA
200 201
EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS DGRPDSGGTL
250 251
RIYADSLKPN IPYKTILLST TDPADFAVAE ALEKYGLEKE NPKDYCIARV
300 301
MLPPGAQHSD EKGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDH
350 351
IPKKTKKHLE GKTPKGKERA DGSGYGSTLP PEKLPYLVEL SPGRRNHFAY
400 401
YNYHTYEDGS DSRDKPKLYR LQLSVTEVGT EKLDDNSIQL FGPGIQPHHC
450 451
DLTNMDGVVT VTPRSMDAET YVEGQRISET TMLQSGMKVQ FGASHVFKFV
500 501
DPSQDHALAK RSVDGGLMVK GPRHKPGIVQ ETTFDLGGDI HSGTALPTSK
550 551
STTRLDSDRV SSASSTAERG MVKPMIRVEQ QPDYRRQESR TQDASGPELI
600 601
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSNQY
650 651
RPDISPTERT HKVIAVVNKM VSMMEGVIQK QKNIAGALAF WMANASELLN
700 701
FIKQDRDLSR ITLDAQDVLA HLVQMAFKYL VHCLQSELNN YMPAFLDDPE
750 751
ENSLQRPKID DVLHTLTGAM SLLRRCRVNA ALTIQLFSQL FHFINMWLFN
800 801
RLVTDPDSGL CSHYWGAIIR QQLGHIEAWA EKQGLELAAD CHLSRIVQAT
850 851
TLLTMDKYAP DDIPNINSTC FKLNSLQLQA LLQNYHCAPD EPFIPTDLIE
900 901
NVVTVAENTA DELARSDGRE VQLEEDPDLQ LPFLLPEDGY SCDVVRNIPN
950 951
GLQEFLDPLC QRGFCRLIPH TRSPGTWTIY FEGADYESHL LRENTELAQP
1000 1001
LRKEPEIITV TLKKQNGMGL SIVAAKGAGQ DKLGIYVKSV VKGGAADVDG
1050 1051
RLAAGDQLLS VDGRSLVGLS QERAAELMTR TSSVVTLEVA KQGAIYHGLA
1100 1101
TLLNQPSPMM QRISDRRGSG KPRPKSEGFE LYNNSTQNGS PESPQLPWAE
1150 1151
YSEPKKLPGD DRLMKNRADH RSSPNVANQP PSPGGKSAYA SGTTAKITSV
1200 1201
STGNLCTEEQ TPPPRPEAYP IPTQTYTREY FTFPASKSQD RMAPPQNQWP
1250 1251
NYEEKPHMHT DSNHSSIAIQ RVTRSQEELR EDKAYQLERH RIEAAMDRKS
1300 1301
DSDMWINQSS SLDSSTSSQE HLNHSSKSVT PASTLTKSGP GRWKTPAAIP
1350 1351
ATPVAVSQPI RTDLPPPPPP PPVHYAGDFD GMSMDLPLPP PPSANQIGLP
1400 1401
SAQVAAAERR KREEHQRWYE KEKARLEEER ERKRREQERK LGQMRTQSLN
1450 1451
PAPFSPLTAQ QMKPEKPSTL QRPQETVIRE LQPQQQPRTI ERRDLQYITV
1500 1501
SKEELSSGDS LSPDPWKRDA KEKLEKQQQM HIVDMLSKEI QELQSKPDRS
1550 1551
AEESDRLRKL MLEWQFQKRL QESKQKDEDD EEEEDDDVDT MLIMQRLEAE
1600 1601
RRARLQDEER RRQQQLEEMR KREAEDRARQ EEERRRQEEE RTKRDAEEKR
1650 1651
RQEEGYYSRL EAERRRQHDE AARRLLEPEA PGLCRPPLPR DYEPPSPSPA
1700 1701
PGAPPPPPQR NASYLKTQVL SPDSLFTAKF VAYNEEEEEE DCSLAGPNSY
1750 1751
PGSTGAAVGA HDACRDAKEK RSKSQDADSP GSSGAPENLT FKERQRLFSQ
1800 1801
GQDVSNKVKA SRKLTELENE LNTK
1824
Show the unformatted sequence. |
| Checksums: |
CRC64:51486232F183A3BA
MD5:997feb245c8b7f3a813784f39eb49f76
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| PDZ | 1008 - 1090 | 1T2M | A | 7 - 89 | Jmol AstexViewer SPICE |
| 1XZ9 | A | 13 - 95 | Jmol AstexViewer SPICE | ||
| 2AIN | A | 7 - 89 | Jmol AstexViewer SPICE | ||
| 2EXG | A | 13 - 95 | Jmol AstexViewer SPICE |