Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
188  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BACE1_HUMAN (P56817)

Summary

This is the summary of UniProt entry BACE1_HUMAN (P56817).

Description: Beta-secretase 1 EC=3.4.23.46
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 501 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 21
low_complexity n/a 27 45
disorder n/a 39 63
Pfam A Asp 74 418
disorder n/a 75 76
transmembrane n/a 458 478
low_complexity n/a 478 489

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P56817. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPLG LRLPRETDEE
50
51
PEEPGRRGSF VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA
100
101
VGAAPHPFLH RYYQRQLSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH
150
151
GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARP DDSLEPFFDS
200
201
LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI DHSLYTGSLW
250
251
YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK
300
301
VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG
350
351
EVTNQSFRIT ILPQQYLRPV EDVATSQDDC YKFAISQSST GTVMGAVIME
400
401
GFYVVFDRAR KRIGFAVSAC HVHDEFRTAA VEGPFVTLDM EDCGYNIPQT
450
451
DESTLMTIAY VMAAICALFM LPLCLMVCQW CCLRCLRQQH DDFADDISLL
500
501
K                                                     
501
 

Show the unformatted sequence.

Checksums:
CRC64:377CE4C838C09F05
MD5:5f7de880acc59651963325f2307e3c2d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Asp 74 - 418 1FKN A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
1M4H A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
1SGZ A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
D 13 - 357 Jmol AstexViewer SPICE
1TQF A 13 - 357 Jmol AstexViewer SPICE
1W50 A 13 - 357 Jmol AstexViewer SPICE
1W51 A 13 - 357 Jmol AstexViewer SPICE
1XN2 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
D 13 - 357 Jmol AstexViewer SPICE
1XN3 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
D 13 - 357 Jmol AstexViewer SPICE
1XS7 D 13 - 357 Jmol AstexViewer SPICE
1YM2 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
1YM4 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
2B8L A 13 - 357 Jmol AstexViewer SPICE
2B8V A 13 - 357 Jmol AstexViewer SPICE
2F3E A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
2F3F A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
2FDP A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
2G94 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
D 13 - 357 Jmol AstexViewer SPICE
2HIZ A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
2HM1 A 13 - 357 Jmol AstexViewer SPICE
2IQG A 13 - 357 Jmol AstexViewer SPICE
2IRZ A 13 - 357 Jmol AstexViewer SPICE
2IS0 A 13 - 357 Jmol AstexViewer SPICE
2NTR A 13 - 357 Jmol AstexViewer SPICE
2OAH A 13 - 357 Jmol AstexViewer SPICE
2OF0 A 13 - 357 Jmol AstexViewer SPICE
2OHK A 13 - 357 Jmol AstexViewer SPICE
2OHL A 13 - 357 Jmol AstexViewer SPICE
2OHM A 13 - 357 Jmol AstexViewer SPICE
2OHN A 13 - 357 Jmol AstexViewer SPICE
2OHP A 13 - 357 Jmol AstexViewer SPICE
2OHQ A 13 - 357 Jmol AstexViewer SPICE
2OHR A 13 - 357 Jmol AstexViewer SPICE
2OHS A 13 - 357 Jmol AstexViewer SPICE
2OHT A 13 - 357 Jmol AstexViewer SPICE
2OHU A 13 - 357 Jmol AstexViewer SPICE
2P4J A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
D 13 - 357 Jmol AstexViewer SPICE
2P83 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
2P8H A 13 - 357 Jmol AstexViewer SPICE
2PH6 A 13 - 357 Jmol AstexViewer SPICE
2PH8 A 13 - 357 Jmol AstexViewer SPICE
2Q11 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
2Q15 A 13 - 357 Jmol AstexViewer SPICE
2QK5 A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
2QMD A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
2QMF A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
2QMG A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
2QP8 A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
2QU2 A 75 - 419 Jmol AstexViewer SPICE
2QU3 A 75 - 419 Jmol AstexViewer SPICE
2QZK A 13 - 357 Jmol AstexViewer SPICE
2QZL A 13 - 357 Jmol AstexViewer SPICE
2VA5 A 13 - 357 Jmol AstexViewer SPICE
2VA6 A 13 - 357 Jmol AstexViewer SPICE
2VA7 A 13 - 357 Jmol AstexViewer SPICE
2VIE A 74 - 418 Jmol AstexViewer SPICE
2VIJ A 74 - 418 Jmol AstexViewer SPICE
2VIY A 74 - 418 Jmol AstexViewer SPICE
2VIZ A 74 - 418 Jmol AstexViewer SPICE
2VJ6 A 74 - 418 Jmol AstexViewer SPICE
2VJ7 A 74 - 418 Jmol AstexViewer SPICE
2VJ9 A 74 - 418 Jmol AstexViewer SPICE
2VKM A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
D 13 - 357 Jmol AstexViewer SPICE
2VNM A 74 - 418 Jmol AstexViewer SPICE
2VNN A 74 - 418 Jmol AstexViewer SPICE
2WEZ A 74 - 418 Jmol AstexViewer SPICE
2WF0 A 74 - 418 Jmol AstexViewer SPICE
2WF1 A 74 - 418 Jmol AstexViewer SPICE
2WF2 A 74 - 418 Jmol AstexViewer SPICE
2WF3 A 74 - 418 Jmol AstexViewer SPICE
2WF4 A 74 - 418 Jmol AstexViewer SPICE
2WJO A 13 - 357 Jmol AstexViewer SPICE
2XFI A 74 - 418 Jmol AstexViewer SPICE
2XFJ A 74 - 418 Jmol AstexViewer SPICE
2XFK A 74 - 418 Jmol AstexViewer SPICE
2ZDZ A 75 - 419 Jmol AstexViewer SPICE
2ZE1 A 75 - 419 Jmol AstexViewer SPICE
2ZHR A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
2ZHS A 13 - 357 Jmol AstexViewer SPICE
2ZHT A 13 - 357 Jmol AstexViewer SPICE
2ZHU A 13 - 357 Jmol AstexViewer SPICE
2ZHV A 13 - 357 Jmol AstexViewer SPICE
2ZJH A 13 - 357 Jmol AstexViewer SPICE
2ZJI A 13 - 357 Jmol AstexViewer SPICE
2ZJJ A 13 - 357 Jmol AstexViewer SPICE
2ZJK A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
2ZJL A 13 - 357 Jmol AstexViewer SPICE
2ZJM A 13 - 357 Jmol AstexViewer SPICE
2ZJN A 13 - 357 Jmol AstexViewer SPICE
3BRA A 13 - 357 Jmol AstexViewer SPICE
3BUF A 13 - 357 Jmol AstexViewer SPICE
3BUG A 13 - 357 Jmol AstexViewer SPICE
3BUH A 13 - 357 Jmol AstexViewer SPICE
3CIB A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3CIC A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3CID A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3CKP A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3CKR A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3DM6 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3DUY A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3DV1 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3DV5 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3EXO A 13 - 357 Jmol AstexViewer SPICE
3FKT A 33 - 377 Jmol AstexViewer SPICE
3H0B A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3HVG A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3HW1 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3I25 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3IGB A 75 - 419 Jmol AstexViewer SPICE
3IN3 A 75 - 419 Jmol AstexViewer SPICE
3IN4 A 75 - 419 Jmol AstexViewer SPICE
3IND A 75 - 419 Jmol AstexViewer SPICE
3INE A 75 - 419 Jmol AstexViewer SPICE
3INF A 75 - 419 Jmol AstexViewer SPICE
3INH A 75 - 419 Jmol AstexViewer SPICE
3IVH A 74 - 418 Jmol AstexViewer SPICE
3IVI A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
C 74 - 418 Jmol AstexViewer SPICE
3IXJ A 61 - 405 Jmol AstexViewer SPICE
B 61 - 405 Jmol AstexViewer SPICE
C 61 - 405 Jmol AstexViewer SPICE
3IXK A 61 - 405 Jmol AstexViewer SPICE
B 61 - 405 Jmol AstexViewer SPICE
C 61 - 405 Jmol AstexViewer SPICE
3K5C A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3K5D A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3K5F A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3K5G A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3KMX A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3KMY A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3KN0 A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3KYR A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3L38 A 75 - 419 Jmol AstexViewer SPICE
3L3A A 75 - 419 Jmol AstexViewer SPICE
3L58 A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3L59 A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3L5B A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3L5C A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3L5D A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3L5E A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3L5F A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3LHG A 75 - 419 Jmol AstexViewer SPICE
3LNK A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3LPI A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3LPJ A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3LPK A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
3MSJ A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3MSK A 13 - 357 Jmol AstexViewer SPICE
3MSL A 13 - 357 Jmol AstexViewer SPICE
3N4L A 19 - 363 Jmol AstexViewer SPICE
B 19 - 363 Jmol AstexViewer SPICE
C 19 - 363 Jmol AstexViewer SPICE
3NSH A 19 - 363 Jmol AstexViewer SPICE
B 19 - 363 Jmol AstexViewer SPICE
C 19 - 363 Jmol AstexViewer SPICE
3OHF A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
3OHH A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
3OOZ A 75 - 419 Jmol AstexViewer SPICE
3PI5 A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3QBH A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3QI1 A 19 - 363 Jmol AstexViewer SPICE
3R1G B 74 - 418 Jmol AstexViewer SPICE
3R2F A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
D 13 - 357 Jmol AstexViewer SPICE
E 13 - 357 Jmol AstexViewer SPICE
3RSV A 13 - 357 Jmol AstexViewer SPICE
3RSX A 13 - 357 Jmol AstexViewer SPICE
3RTH A 13 - 357 Jmol AstexViewer SPICE
3RTM A 13 - 357 Jmol AstexViewer SPICE
3RTN A 13 - 357 Jmol AstexViewer SPICE
3RU1 A 13 - 357 Jmol AstexViewer SPICE
3RVI A 13 - 357 Jmol AstexViewer SPICE
3S2O A 13 - 357 Jmol AstexViewer SPICE
3S7L A 75 - 419 Jmol AstexViewer SPICE
3S7M A 75 - 419 Jmol AstexViewer SPICE
3SKF A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
3SKG A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
D 13 - 357 Jmol AstexViewer SPICE
E 13 - 357 Jmol AstexViewer SPICE
3TPJ A 13 - 357 Jmol AstexViewer SPICE
3TPL A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3TPP A 13 - 357 Jmol AstexViewer SPICE
3TPR A 13 - 357 Jmol AstexViewer SPICE
3U6A A 13 - 357 Jmol AstexViewer SPICE
B 13 - 357 Jmol AstexViewer SPICE
C 13 - 357 Jmol AstexViewer SPICE
3UDH A 13 - 357 Jmol AstexViewer SPICE
3UDJ A 13 - 357 Jmol AstexViewer SPICE
3UDK A 13 - 357 Jmol AstexViewer SPICE
3UDM A 13 - 357 Jmol AstexViewer SPICE
3UDN A 13 - 357 Jmol AstexViewer SPICE
3UDP A 13 - 357 Jmol AstexViewer SPICE
3UDQ A 13 - 357 Jmol AstexViewer SPICE
3UDR A 13 - 357 Jmol AstexViewer SPICE
3UDY A 13 - 357 Jmol AstexViewer SPICE
3UFL A 13 - 357 Jmol AstexViewer SPICE
4ACU A 13 - 357 Jmol AstexViewer SPICE
4ACX A 13 - 357 Jmol AstexViewer SPICE
4DH6 A 13 - 357 Jmol AstexViewer SPICE
4DJU A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
4DJV A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
4DJW A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
4DJX A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE
4DJY A 74 - 418 Jmol AstexViewer SPICE
B 74 - 418 Jmol AstexViewer SPICE