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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TPIS_HUMAN (P60174)

Summary

This is the summary of UniProt entry TPIS_HUMAN (P60174).

Description: Triosephosphate isomerase EC=5.3.1.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 286 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A TIM 44 282
disorder n/a 213 214

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P60174. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEDGEEAEF HFAALYISGQ WPRLRADTDL QRLGSSAMAP SRKFFVGGNW
50
51
KMNGRKQSLG ELIGTLNAAK VPADTEVVCA PPTAYIDFAR QKLDPKIAVA
100
101
AQNCYKVTNG AFTGEISPGM IKDCGATWVV LGHSERRHVF GESDELIGQK
150
151
VAHALAEGLG VIACIGEKLD EREAGITEKV VFEQTKVIAD NVKDWSKVVL
200
201
AYEPVWAIGT GKTATPQQAQ EVHEKLRGWL KSNVSDAVAQ STRIIYGGSV
250
251
TGATCKELAS QPDVDGFLVG GASLKPEFVD IINAKQ               
286
 

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Checksums:
CRC64:E6C2157706AE97F8
MD5:fe4e151a28e9afc416b70827e2db5f52

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TIM 44 - 282 1HTI A 6 - 244 Jmol AstexViewer SPICE
B 6 - 244 Jmol AstexViewer SPICE
1WYI A 6 - 244 Jmol AstexViewer SPICE
B 6 - 244 Jmol AstexViewer SPICE
2JK2 A 6 - 244 Jmol AstexViewer SPICE
B 6 - 244 Jmol AstexViewer SPICE
2VOM A 6 - 244 Jmol AstexViewer SPICE
B 6 - 244 Jmol AstexViewer SPICE
C 6 - 244 Jmol AstexViewer SPICE
D 6 - 244 Jmol AstexViewer SPICE
60 - 74 2IAM P 23 - 37 Jmol AstexViewer SPICE
2IAN C 23 - 37 Jmol AstexViewer SPICE
H 23 - 37 Jmol AstexViewer SPICE
M 23 - 37 Jmol AstexViewer SPICE
R 23 - 37 Jmol AstexViewer SPICE