Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RAN_HUMAN (P62826)

Summary

This is the summary of UniProt entry RAN_HUMAN (P62826).

Description: GTP-binding nuclear protein Ran
Source organism: Homo sapiens (Human)
Length: 216 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Ras 12 170
Pfam B Pfam-B_8012 171 214
disorder n/a 212 216

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P62826. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL
50
51
VFHTNRGPIK FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN
100
101
VPNWHRDLVR VCENIPIVLC GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS
150
151
AKSNYNFEKP FLWLARKLIG DPNLEFVAMP ALAPPEVVMD PALAAQYEHD
200
201
LEVAQTTALP DEDDDL                                     
216
 

Show the unformatted sequence.

Checksums:
CRC64:D5C9B7275C34BCE0
MD5:47fdbe2a237c269edfa2519ccde0994d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ras 12 - 170 1I2M A 12 - 170 Jmol AstexViewer SPICE
C 12 - 170 Jmol AstexViewer SPICE
1IBR A 12 - 170 Jmol AstexViewer SPICE
C 12 - 170 Jmol AstexViewer SPICE
1K5D A 12 - 170 Jmol AstexViewer SPICE
D 12 - 170 Jmol AstexViewer SPICE
G 12 - 170 Jmol AstexViewer SPICE
J 12 - 170 Jmol AstexViewer SPICE
1QBK C 12 - 170 Jmol AstexViewer SPICE
1RRP A 12 - 170 Jmol AstexViewer SPICE
C 12 - 170 Jmol AstexViewer SPICE
3EA5 A 12 - 170 Jmol AstexViewer SPICE
C 12 - 170 Jmol AstexViewer SPICE
3GJ0 A 12 - 170 Jmol AstexViewer SPICE
B 12 - 170 Jmol AstexViewer SPICE
3GJ3 A 12 - 170 Jmol AstexViewer SPICE
3GJ4 A 12 - 170 Jmol AstexViewer SPICE
C 12 - 170 Jmol AstexViewer SPICE
3GJ5 A 12 - 170 Jmol AstexViewer SPICE
C 12 - 170 Jmol AstexViewer SPICE
3GJ6 A 12 - 170 Jmol AstexViewer SPICE
3GJ7 A 12 - 170 Jmol AstexViewer SPICE
C 12 - 170 Jmol AstexViewer SPICE
3GJ8 A 12 - 170 Jmol AstexViewer SPICE
C 12 - 170 Jmol AstexViewer SPICE
3GJX C 12 - 170 Jmol AstexViewer SPICE
F 12 - 170 Jmol AstexViewer SPICE
3NBY C 12 - 170 Jmol AstexViewer SPICE
F 12 - 170 Jmol AstexViewer SPICE
3NBZ C 12 - 170 Jmol AstexViewer SPICE
F 12 - 170 Jmol AstexViewer SPICE
3NC0 C 12 - 170 Jmol AstexViewer SPICE
F 12 - 170 Jmol AstexViewer SPICE
3NC1 C 12 - 170 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.