Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
60  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PPIA_HUMAN (P62937)

Summary

This is the summary of UniProt entry PPIA_HUMAN (P62937).

Description: Peptidyl-prolyl cis-trans isomerase A EC=5.2.1.8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 165 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Pro_isomerase 7 163
disorder n/a 100 101
disorder n/a 143 144

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P62937. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG
50
51
SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM
100
101
ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG
150
151
KTSKKITIAD CGQLE                                      
165
 

Show the unformatted sequence.

Checksums:
CRC64:9B2E637A555E4434
MD5:5364a334c335e7d706a5569fbc3f602d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pro_isomerase 7 - 163 1AK4 A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1AWQ A 1007 - 1163 Jmol AstexViewer SPICE
1AWR A 1007 - 1163 Jmol AstexViewer SPICE
B 1007 - 1163 Jmol AstexViewer SPICE
C 1007 - 1163 Jmol AstexViewer SPICE
D 1007 - 1163 Jmol AstexViewer SPICE
E 1007 - 1163 Jmol AstexViewer SPICE
F 1007 - 1163 Jmol AstexViewer SPICE
1AWS A 1007 - 1163 Jmol AstexViewer SPICE
1AWT A 1007 - 1163 Jmol AstexViewer SPICE
B 1007 - 1163 Jmol AstexViewer SPICE
C 1007 - 1163 Jmol AstexViewer SPICE
D 1007 - 1163 Jmol AstexViewer SPICE
E 1007 - 1163 Jmol AstexViewer SPICE
F 1007 - 1163 Jmol AstexViewer SPICE
1AWU A 1007 - 1163 Jmol AstexViewer SPICE
1AWV A 1007 - 1163 Jmol AstexViewer SPICE
B 1007 - 1163 Jmol AstexViewer SPICE
C 1007 - 1163 Jmol AstexViewer SPICE
D 1007 - 1163 Jmol AstexViewer SPICE
E 1007 - 1163 Jmol AstexViewer SPICE
F 1007 - 1163 Jmol AstexViewer SPICE
1BCK A 7 - 163 Jmol AstexViewer SPICE
1CWA A 7 - 163 Jmol AstexViewer SPICE
1CWB A 7 - 163 Jmol AstexViewer SPICE
1CWC A 7 - 163 Jmol AstexViewer SPICE
1CWF A 7 - 163 Jmol AstexViewer SPICE
1CWH A 7 - 163 Jmol AstexViewer SPICE
1CWI A 7 - 163 Jmol AstexViewer SPICE
1CWJ A 7 - 163 Jmol AstexViewer SPICE
1CWK A 7 - 163 Jmol AstexViewer SPICE
1CWL A 7 - 163 Jmol AstexViewer SPICE
1CWM A 7 - 163 Jmol AstexViewer SPICE
1CWO A 7 - 163 Jmol AstexViewer SPICE
1FGL A 7 - 163 Jmol AstexViewer SPICE
1M63 C 7 - 163 Jmol AstexViewer SPICE
G 7 - 163 Jmol AstexViewer SPICE
1M9C A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1M9D A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1M9E A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1M9F A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1M9X A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
E 7 - 163 Jmol AstexViewer SPICE
F 7 - 163 Jmol AstexViewer SPICE
1M9Y A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
E 7 - 163 Jmol AstexViewer SPICE
F 7 - 163 Jmol AstexViewer SPICE
1MF8 C 7 - 163 Jmol AstexViewer SPICE
1MIK A 7 - 163 Jmol AstexViewer SPICE
1NMK A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1OCA A 7 - 163 Jmol AstexViewer SPICE
1RMH A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1VBS A 7 - 163 Jmol AstexViewer SPICE
1VBT A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1W8L A 7 - 163 Jmol AstexViewer SPICE
1W8M A 7 - 163 Jmol AstexViewer SPICE
1W8V A 7 - 163 Jmol AstexViewer SPICE
1YND A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
1ZKF A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
2ALF A 7 - 163 Jmol AstexViewer SPICE
2CPL A 7 - 163 Jmol AstexViewer SPICE
2CYH A 7 - 163 Jmol AstexViewer SPICE
2RMA A 7 - 163 Jmol AstexViewer SPICE
C 7 - 163 Jmol AstexViewer SPICE
E 7 - 163 Jmol AstexViewer SPICE
G 7 - 163 Jmol AstexViewer SPICE
I 7 - 163 Jmol AstexViewer SPICE
K 7 - 163 Jmol AstexViewer SPICE
M 7 - 163 Jmol AstexViewer SPICE
O 7 - 163 Jmol AstexViewer SPICE
Q 7 - 163 Jmol AstexViewer SPICE
S 7 - 163 Jmol AstexViewer SPICE
2RMB A 7 - 163 Jmol AstexViewer SPICE
C 7 - 163 Jmol AstexViewer SPICE
E 7 - 163 Jmol AstexViewer SPICE
G 7 - 163 Jmol AstexViewer SPICE
I 7 - 163 Jmol AstexViewer SPICE
K 7 - 163 Jmol AstexViewer SPICE
M 7 - 163 Jmol AstexViewer SPICE
O 7 - 163 Jmol AstexViewer SPICE
Q 7 - 163 Jmol AstexViewer SPICE
S 7 - 163 Jmol AstexViewer SPICE
2X25 B 7 - 163 Jmol AstexViewer SPICE
2X2A A 7 - 163 Jmol AstexViewer SPICE
B 7 - 163 Jmol AstexViewer SPICE
2X2C K 7 - 163 Jmol AstexViewer SPICE
M 7 - 163 Jmol AstexViewer SPICE
O 7 - 163 Jmol AstexViewer SPICE
Q 7 - 163 Jmol AstexViewer SPICE
S 7 - 163 Jmol AstexViewer SPICE
2X2D B 7 - 163 Jmol AstexViewer SPICE
C 7 - 163 Jmol AstexViewer SPICE
2XGY B 7 - 163 Jmol AstexViewer SPICE
3CYH A 7 - 163 Jmol AstexViewer SPICE
3CYS A 7 - 163 Jmol AstexViewer SPICE
3K0M A 7 - 163 Jmol AstexViewer SPICE
3K0N A 7 - 163 Jmol AstexViewer SPICE
3K0O A 7 - 163 Jmol AstexViewer SPICE
3K0P A 7 - 163 Jmol AstexViewer SPICE
3K0Q A 7 - 163 Jmol AstexViewer SPICE
3K0R A 7 - 163 Jmol AstexViewer SPICE
3RDD A 7 - 163 Jmol AstexViewer SPICE
4CYH A 7 - 163 Jmol AstexViewer SPICE
5CYH A 7 - 163 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.