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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MK01_RAT (P63086)

Summary

This is the summary of UniProt entry MK01_RAT (P63086).

Description: Mitogen-activated protein kinase 1 EC=2.7.11.24
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
View Pfam proteome data.
Length: 358 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
low_complexity n/a 2 7
Pfam A Pkinase 23 311
low_complexity n/a 330 344

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P63086. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA
50
51
IKKISPFEHQ TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY
100
101
IVQDLMETDL YKLLKTQHLS NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP
150
151
SNLLLNTTCD LKICDFGLAR VADPDHDHTG FLTEYVATRW YRAPEIMLNS
200
201
KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG ILGSPSQEDL
250
251
NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI
300
301
EVEQALAHPY LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA
350
351
RFQPGYRS                                              
358
 

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Checksums:
CRC64:3BBCF22471EDBA0B
MD5:85206ff7bd40321162057a93f9f34e61

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 23 - 311 1ERK A 23 - 311 Jmol AstexViewer SPICE
1GOL A 23 - 311 Jmol AstexViewer SPICE
2ERK A 23 - 311 Jmol AstexViewer SPICE
2FYS A 23 - 311 Jmol AstexViewer SPICE
B 23 - 311 Jmol AstexViewer SPICE
2GPH A 23 - 311 Jmol AstexViewer SPICE
2Z7L A 25 - 313 Jmol AstexViewer SPICE
3C9W A 23 - 311 Jmol AstexViewer SPICE
B 23 - 311 Jmol AstexViewer SPICE
3ERK A 23 - 311 Jmol AstexViewer SPICE
3O71 A 23 - 311 Jmol AstexViewer SPICE
3QYI A 23 - 311 Jmol AstexViewer SPICE
3QYW A 23 - 311 Jmol AstexViewer SPICE
3QYZ A 23 - 311 Jmol AstexViewer SPICE
3R63 A 23 - 311 Jmol AstexViewer SPICE
4ERK A 23 - 311 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.