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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FKBP4_HUMAN (Q02790)

Summary

This is the summary of UniProt entry FKBP4_HUMAN (Q02790).

Description: Peptidyl-prolyl cis-trans isomerase FKBP4 EC=5.2.1.8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 459 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 24
disorder n/a 34 37
Pfam A FKBP_C 43 135
disorder n/a 148 149
disorder n/a 153 156
Pfam A FKBP_C 160 250
coiled_coil n/a 249 269
Pfam A TPR_1 274 298
Pfam A TPR_1 320 352
Pfam A TPR_1 353 386
coiled_coil n/a 401 424
low_complexity n/a 419 429
disorder n/a 421 459

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q02790. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG
50
51
DRVFVHYTGW LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG
100
101
EVCHITCKPE YAYGSAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI
150
151
IRRIQTRGEG YAKPNEGAIV EVALEGYYKD KLFDQRELRF EIGEGENLDL
200
201
PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN AELKYELHLK
250
251
SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKYKQAL LQYKKIVSWL
300
301
EYESSFSNEE AQKAQALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS
350
351
NNEKGLFRRG EAHLAVNDFE LARADFQKVL QLYPNNKAAK TQLAVCQQRI
400
401
RRQLAREKKL YANMFERLAE EENKAKAEAS SGDHPTDTEM KEEQKSNTAG
450
451
SQSQVETEA                                             
459
 

Show the unformatted sequence.

Checksums:
CRC64:6A498105418D9435
MD5:74a70e0128956afd5302d1dca89598ef

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FKBP_C 160 - 250 1P5Q A 160 - 250 Jmol AstexViewer SPICE
B 160 - 250 Jmol AstexViewer SPICE
C 160 - 250 Jmol AstexViewer SPICE
1Q1C A 160 - 250 Jmol AstexViewer SPICE
1QZ2 A 160 - 250 Jmol AstexViewer SPICE
B 160 - 250 Jmol AstexViewer SPICE
C 160 - 250 Jmol AstexViewer SPICE
43 - 135 1N1A A 43 - 135 Jmol AstexViewer SPICE
B 43 - 135 Jmol AstexViewer SPICE
1Q1C A 43 - 135 Jmol AstexViewer SPICE
TPR_1 274 - 298 1P5Q A 274 - 298 Jmol AstexViewer SPICE
B 274 - 298 Jmol AstexViewer SPICE
C 274 - 298 Jmol AstexViewer SPICE
1QZ2 A 274 - 298 Jmol AstexViewer SPICE
B 274 - 298 Jmol AstexViewer SPICE
C 274 - 298 Jmol AstexViewer SPICE
320 - 352 1P5Q A 320 - 352 Jmol AstexViewer SPICE
B 320 - 352 Jmol AstexViewer SPICE
C 320 - 352 Jmol AstexViewer SPICE
1QZ2 A 320 - 352 Jmol AstexViewer SPICE
B 320 - 352 Jmol AstexViewer SPICE
C 320 - 352 Jmol AstexViewer SPICE
353 - 386 1P5Q A 353 - 386 Jmol AstexViewer SPICE
B 353 - 386 Jmol AstexViewer SPICE
C 353 - 386 Jmol AstexViewer SPICE
1QZ2 A 353 - 386 Jmol AstexViewer SPICE
B 353 - 386 Jmol AstexViewer SPICE
C 353 - 386 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.