Summary
This is the summary of UniProt entry TOP2B_HUMAN (Q02880).
| Description: | DNA topoisomerase 2-beta EC=5.99.1.3 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1626 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| low_complexity | n/a | 5 | 19 |
| disorder | n/a | 33 | 46 |
| Pfam A | HATPase_c | 98 | 245 |
| Pfam A | DNA_gyraseB | 287 | 450 |
| Pfam A | Toprim | 477 | 593 |
| Pfam A | DNA_topoisoIV | 734 | 1190 |
| low_complexity | n/a | 1109 | 1121 |
| disorder | n/a | 1110 | 1140 |
| low_complexity | n/a | 1129 | 1142 |
| coiled_coil | n/a | 1159 | 1179 |
| disorder | n/a | 1163 | 1180 |
| disorder | n/a | 1202 | 1216 |
| low_complexity | n/a | 1213 | 1227 |
| disorder | n/a | 1218 | 1234 |
| disorder | n/a | 1236 | 1245 |
| low_complexity | n/a | 1248 | 1269 |
| disorder | n/a | 1253 | 1260 |
| disorder | n/a | 1273 | 1274 |
| disorder | n/a | 1276 | 1362 |
| low_complexity | n/a | 1299 | 1311 |
| low_complexity | n/a | 1336 | 1348 |
| disorder | n/a | 1364 | 1442 |
| low_complexity | n/a | 1376 | 1395 |
| disorder | n/a | 1447 | 1452 |
| disorder | n/a | 1455 | 1616 |
| Pfam A | DTHCT | 1508 | 1611 |
| low_complexity | n/a | 1531 | 1549 |
| low_complexity | n/a | 1563 | 1576 |
| disorder | n/a | 1618 | 1626 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q02880. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAKSGGCGAG AGVGGGNGAL TWVTLFDQNN AAKKEESETA NKNDSSKKLS
50 51
VERVYQKKTQ LEHILLRPDT YIGSVEPLTQ FMWVYDEDVG MNCREVTFVP
100 101
GLYKIFDEIL VNAADNKQRD KNMTCIKVSI DPESNIISIW NNGKGIPVVE
150 151
HKVEKVYVPA LIFGQLLTSS NYDDDEKKVT GGRNGYGAKL CNIFSTKFTV
200 201
ETACKEYKHS FKQTWMNNMM KTSEAKIKHF DGEDYTCITF QPDLSKFKME
250 251
KLDKDIVALM TRRAYDLAGS CRGVKVMFNG KKLPVNGFRS YVDLYVKDKL
300 301
DETGVALKVI HELANERWDV CLTLSEKGFQ QISFVNSIAT TKGGRHVDYV
350 351
VDQVVGKLIE VVKKKNKAGV SVKPFQVKNH IWVFINCLIE NPTFDSQTKE
400 401
NMTLQPKSFG SKCQLSEKFF KAASNCGIVE SILNWVKFKA QTQLNKKCSS
450 451
VKYSKIKGIP KLDDANDAGG KHSLECTLIL TEGDSAKSLA VSGLGVIGRD
500 501
RYGVFPLRGK ILNVREASHK QIMENAEINN IIKIVGLQYK KSYDDAESLK
550 551
TLRYGKIMIM TDQDQDGSHI KGLLINFIHH NWPSLLKHGF LEEFITPIVK
600 601
ASKNKQELSF YSIPEFDEWK KHIENQKAWK IKYYKGLGTS TAKEAKEYFA
650 651
DMERHRILFR YAGPEDDAAI TLAFSKKKID DRKEWLTNFM EDRRQRRLHG
700 701
LPEQFLYGTA TKHLTYNDFI NKELILFSNS DNERSIPSLV DGFKPGQRKV
750 751
LFTCFKRNDK REVKVAQLAG SVAEMSAYHH GEQALMMTIV NLAQNFVGSN
800 801
NINLLQPIGQ FGTRLHGGKD AASPRYIFTM LSTLARLLFP AVDDNLLKFL
850 851
YDDNQRVEPE WYIPIIPMVL INGAEGIGTG WACKLPNYDA REIVNNVRRM
900 901
LDGLDPHPML PNYKNFKGTI QELGQNQYAV SGEIFVVDRN TVEITELPVR
950 951
TWTQVYKEQV LEPMLNGTDK TPALISDYKE YHTDTTVKFV VKMTEEKLAQ
1000 1001
AEAAGLHKVF KLQTTLTCNS MVLFDHMGCL KKYETVQDIL KEFFDLRLSY
1050 1051
YGLRKEWLVG MLGAESTKLN NQARFILEKI QGKITIENRS KKDLIQMLVQ
1100 1101
RGYESDPVKA WKEAQEKAAE EDETQNQHDD SSSDSGTPSG PDFNYILNMS
1150 1151
LWSLTKEKVE ELIKQRDAKG REVNDLKRKS PSDLWKEDLA AFVEELDKVE
1200 1201
SQEREDVLAG MSGKAIKGKV GKPKVKKLQL EETMPSPYGR RIIPEITAMK
1250 1251
ADASKKLLKK KKGDLDTAAV KVEFDEEFSG APVEGAGEEA LTPSVPINKG
1300 1301
PKPKREKKEP GTRVRKTPTS SGKPSAKKVK KRNPWSDDES KSESDLEETE
1350 1351
PVVIPRDSLL RRAAAERPKY TFDFSEEEDD DADDDDDDNN DLEELKVKAS
1400 1401
PITNDGEDEF VPSDGLDKDE YTFSPGKSKA TPEKSLHDKK SQDFGNLFSF
1450 1451
PSYSQKSEDD SAKFDSNEED SASVFSPSFG LKQTDKVPSK TVAAKKGKPS
1500 1501
SDTVPKPKRA PKQKKVVEAV NSDSDSEFGI PKKTTTPKGK GRGAKKRKAS
1550 1551
GSENEGDYNP GRKTSKTTSK KPKKTSFDQD SDVDIFPSDF PTEPPSLPRT
1600 1601
GRARKEVKYF AESDEEEDDV DFAMFN
1626
Show the unformatted sequence. |
| Checksums: |
CRC64:E60E9262CC68B05D
MD5:210a8472fb54e4cba1715498c408a7ba
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| DNA_topoisoIV | 734 - 1190 | 3QX3 | A | 729 - 1185 | Jmol AstexViewer SPICE |
| B | 729 - 1185 | Jmol AstexViewer SPICE | |||
| Toprim | 477 - 593 | 3QX3 | A | 472 - 588 | Jmol AstexViewer SPICE |
| B | 472 - 588 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.