Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: LMNB2_HUMAN (Q03252)

Summary

This is the summary of UniProt entry LMNB2_HUMAN (Q03252).

Description: Lamin-B2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 600 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 25
coiled_coil n/a 23 64
Pfam A Filament 25 381
disorder n/a 27 28
coiled_coil n/a 73 121
disorder n/a 116 117
disorder n/a 119 120
coiled_coil n/a 143 198
low_complexity n/a 205 224
disorder n/a 217 222
disorder n/a 235 239
coiled_coil n/a 237 257
disorder n/a 265 287
coiled_coil n/a 280 357
disorder n/a 310 321
disorder n/a 326 348
low_complexity n/a 372 414
disorder n/a 377 420
disorder n/a 422 434
low_complexity n/a 424 441
disorder n/a 436 439
disorder n/a 442 444
Pfam A LTD 443 562
disorder n/a 479 481
disorder n/a 525 531
disorder n/a 555 587
low_complexity n/a 565 581
Pfam B Pfam-B_25978 566 598
disorder n/a 589 591
disorder n/a 594 598

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q03252. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MATPLPGRAG GPATPLSPTR LSRLQEKEEL RELNDRLAHY IDRVRALELE
50
51
NDRLLLKISE KEEVTTREVS GIKALYESEL ADARRVLDET ARERARLQIE
100
101
IGKLRAELDE VNKSAKKREG ELTVAQGRVK DLESLFHRSE VELAAALSDK
150
151
RGLESDVAEL RAQLAKAEDG HAVAKKQLEK ETLMRVDLEN RCQSLQEELD
200
201
FRKSVFEEEV RETRRRHERR LVEVDSSRQQ EYDFKMAQAL EELRSQHDEQ
250
251
VRLYKLELEQ TYQAKLDSAK LSSDQNDKAA SAAREELKEA RMRLESLSYQ
300
301
LSGLQKQASA AEDRIRELEE AMAGERDKFR KMLDAKEQEM TEMRDVMQQQ
350
351
LAEYQELLDV KLALDMEINA YRKLLEGEEE RLKLSPSPSS RVTVSRATSS
400
401
SSGSLSATGR LGRSKRKRLE VEEPLGSGPS VLGTGTGGSG GFHLAQQASA
450
451
SGSVSIEEID LEGKFVQLKN NSDKDQSLGN WRIKRQVLEG EEIAYKFTPK
500
501
YILRAGQMVT VWAAGAGVAH SPPSTLVWKG QSSWGTGESF RTVLVNADGE
550
551
EVAMRTVKKS SVMRENENGE EEEEEAEFGE EDLFHQQGDP RTTSRGCYVM
600
601
                                                      
600
 

Show the unformatted sequence.

Checksums:
CRC64:3A1B9098F7EA943B
MD5:1ef0496fc5a4b3e0a08cdf0f07a3ac21

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LTD 449 - 562 2LLL A 449 - 562 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.