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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SRY_HUMAN (Q05066)

Summary

This is the summary of UniProt entry SRY_HUMAN (Q05066).

Description: Sex-determining region Y protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 204 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 47 58
Pfam A HMG_box 60 128
disorder n/a 78 86
disorder n/a 121 130
disorder n/a 140 141
disorder n/a 170 171
disorder n/a 174 195
disorder n/a 197 202

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q05066. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE
50
51
NSKGNVQDRV KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM
100
101
LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLPK NCSLLPADPA
150
151
SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRYSH
200
201
WTKL                                                  
204
 

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Checksums:
CRC64:84323C30A9C2173E
MD5:e18f23d6455d12785dd28f65a7be41c6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HMG_box 60 - 128 1HRY A 5 - 73 Jmol AstexViewer SPICE
1HRZ A 5 - 73 Jmol AstexViewer SPICE
1J46 A 5 - 73 Jmol AstexViewer SPICE
1J47 A 5 - 73 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.