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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PP2BA_HUMAN (Q08209)

Summary

This is the summary of UniProt entry PP2BA_HUMAN (Q08209).

Description: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform EC=3.1.3.16
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 521 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 6
Pfam B Pfam-B_1043 16 47
Pfam A Metallophos 83 285
disorder n/a 383 384
disorder n/a 434 439
disorder n/a 448 449
disorder n/a 463 464
disorder n/a 469 521
low_complexity n/a 504 519

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q08209. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL
50
51
MKEGRLEESV ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK
100
101
LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWALKILY PKTLFLLRGN
150
151
HECRHLTEYF TFKQECKIKY SERVYDACMD AFDCLPLAAL MNQQFLCVHG
200
201
GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG NEKTQEHFTH
250
251
NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
300
301
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF
350
351
TWSLPFVGEK VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI
400
401
RAIGKMARVF SVLREESESV LTLKGLTPTG MLPSGVLSGG KQTLQSATVE
450
451
AIEADEAIKG FSPQHKITSF EEAKGLDRIN ERMPPRRDAM PSDANLNSIN
500
501
KALTSETNGT DSNGSNSSNI Q                               
521
 

Show the unformatted sequence.

Checksums:
CRC64:16480D62DDBF1F40
MD5:a0008748eae2588e0694f7f582500d61

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Metallophos 83 - 285 1AUI A 83 - 285 Jmol AstexViewer SPICE
1M63 A 83 - 285 Jmol AstexViewer SPICE
E 83 - 285 Jmol AstexViewer SPICE
1MF8 A 83 - 285 Jmol AstexViewer SPICE
2JOG A 83 - 285 Jmol AstexViewer SPICE
2P6B A 83 - 285 Jmol AstexViewer SPICE
C 83 - 285 Jmol AstexViewer SPICE
3LL8 A 83 - 285 Jmol AstexViewer SPICE
C 83 - 285 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.