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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTN13_HUMAN (Q12923)

Summary

This is the summary of UniProt entry PTN13_HUMAN (Q12923).

Description: Tyrosine-protein phosphatase non-receptor type 13 EC=3.1.3.48
Source organism: Homo sapiens (Human)
Length: 2485 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam B Pfam-B_1600 1 379
low_complexity n/a 52 65
disorder n/a 186 208
disorder n/a 214 220
disorder n/a 255 260
disorder n/a 265 281
disorder n/a 283 286
disorder n/a 318 319
disorder n/a 324 342
disorder n/a 361 362
disorder n/a 364 369
disorder n/a 373 379
disorder n/a 389 393
disorder n/a 405 410
low_complexity n/a 413 426
disorder n/a 415 416
disorder n/a 418 419
disorder n/a 422 428
disorder n/a 432 437
disorder n/a 439 468
coiled_coil n/a 473 500
Pfam A FERM_N 576 664
Pfam A FERM_M 665 781
low_complexity n/a 699 707
Pfam A FERM_C 787 876
low_complexity n/a 823 834
disorder n/a 946 974
disorder n/a 981 1071
Pfam A PDZ 1093 1176
disorder n/a 1175 1178
disorder n/a 1184 1194
disorder n/a 1196 1199
disorder n/a 1203 1208
disorder n/a 1210 1262
disorder n/a 1265 1373
Pfam A PDZ 1368 1450
disorder n/a 1377 1385
disorder n/a 1393 1394
disorder n/a 1397 1414
disorder n/a 1416 1423
disorder n/a 1425 1426
disorder n/a 1430 1433
disorder n/a 1446 1451
disorder n/a 1453 1482
disorder n/a 1485 1488
Pfam A PDZ 1501 1585
disorder n/a 1568 1569
disorder n/a 1596 1599
disorder n/a 1603 1672
low_complexity n/a 1645 1662
disorder n/a 1674 1708
disorder n/a 1715 1773
low_complexity n/a 1736 1749
coiled_coil n/a 1771 1791
Pfam A PDZ 1788 1866
disorder n/a 1828 1831
Pfam A PDZ 1883 1962
disorder n/a 1971 1983
disorder n/a 1991 1994
disorder n/a 2002 2007
disorder n/a 2011 2012
disorder n/a 2035 2036
disorder n/a 2039 2050
disorder n/a 2053 2071
low_complexity n/a 2067 2079
disorder n/a 2073 2078
disorder n/a 2080 2081
disorder n/a 2084 2113
disorder n/a 2133 2172
Pfam A Y_phosphatase 2237 2466
low_complexity n/a 2471 2484
disorder n/a 2482 2485

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q12923. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQELFRKVS LADPAALGFI
50
51
ISPWSLLLLP SGSVSFTDEN ISNQDLRAFT APEVLQNQSL TSLSDVEKIH
100
101
IYSLGMTLYW GADYEVPQSQ PIKLGDHLNS ILLGMCEDVI YARVSVRTVL
150
151
DACSAHIRNS NCAPSFSYVK HLVKLVLGNL SGTDQLSCNS EQKPDRSQAI
200
201
RDRLRGKGLP TGRSSTSDVL DIQKPPLSHQ TFLNKGLSKS MGFLSIKDTQ
250
251
DENYFKDILS DNSGREDSEN TFSPYQFKTS GPEKKPIPGI DVLSKKKIWA
300
301
SSMDLLCTAD RDFSSGETAT YRRCHPEAVT VRTSTTPRKK EARYSDGSIA
350
351
LDIFGPQKMD PIYHTRELPT SSAISSALDR IRERQKKLQV LREAMNVEEP
400
401
VRRYKTYHGD VFSTSSESPS IISSESDFRQ VRRSEASKRF ESSSGLPGVD
450
451
ETLSQGQSQR PSRQYETPFE GNLINQEIML KRQEEELMQL QAKMALRQSR
500
501
LSLYPGDTIK ASMLDITRDP LREIALETAM TQRKLRNFFG PEFVKMTIEP
550
551
FISLDLPRSI LTKKGKNEDN RRKVNIMLLN GQRLELTCDT KTICKDVFDM
600
601
VVAHIGLVEH HLFALATLKD NEYFFVDPDL KLTKVAPEGW KEEPKKKTKA
650
651
TVNFTLFFRI KFFMDDVSLI QHTLTCHQYY LQLRKDILEE RMHCDDETSL
700
701
LLASLALQAE YGDYQPEVHG VSYFRMEHYL PARVMEKLDL SYIKEELPKL
750
751
HNTYVGASEK ETELEFLKVC QRLTEYGVHF HRVHPEKKSQ TGILLGVCSK
800
801
GVLVFEVHNG VRTLVLRFPW RETKKISFSK KKITLQNTSD GIKHGFQTDN
850
851
SKICQYLLHL CSYQHKFQLQ MRARQSNQDA QDIERASFRS LNLQAESVRG
900
901
FNMGRAISTG SLASSTLNKL AVRPLSVQAE ILKRLSCSEL SLYQPLQNSS
950
951
KEKNDKASWE EKPREMSKSY HDLSQASLYP HRKNVIVNME PPPQTVAELV
1000
1001
GKPSHQMSRS DAESLAGVTK LNNSKSVASL NRSPERRKHE SDSSSIEDPG
1050
1051
QAYVLGMTMH SSGNSSSQVP LKENDVLHKR WSIVSSPERE ITLVNLKKDA
1100
1101
KYGLGFQIIG GEKMGRLDLG IFISSVAPGG PADLDGCLKP GDRLISVNSV
1150
1151
SLEGVSHHAA IEILQNAPED VTLVISQPKE KISKVPSTPV HLTNEMKNYM
1200
1201
KKSSYMQDSA IDSSSKDHHW SRGTLRHISE NSFGPSGGLR EGSLSSQDSR
1250
1251
TESASLSQSQ VNGFFASHLG DQTWQESQHG SPSPSVISKA TEKETFTDSN
1300
1301
QSKTKKPGIS DVTDYSDRGD SDMDEATYSS SQDHQTPKQE SSSSVNTSNK
1350
1351
MNFKTFSSSP PKPGDIFEVE LAKNDNSLGI SVTGGVNTSV RHGGIYVKAV
1400
1401
IPQGAAESDG RIHKGDRVLA VNGVSLEGAT HKQAVETLRN TGQVVHLLLE
1450
1451
KGQSPTSKEH VPVTPQCTLS DQNAQGQGPE KVKKTTQVKD YSFVTEENTF
1500
1501
EVKLFKNSSG LGFSFSREDN LIPEQINASI VRVKKLFPGQ PAAESGKIDV
1550
1551
GDVILKVNGA SLKGLSQQEV ISALRGTAPE VFLLLCRPPP GVLPEIDTAL
1600
1601
LTPLQSPAQV LPNSSKDSSQ PSCVEQSTSS DENEMSDKSK KQCKSPSRRD
1650
1651
SYSDSSGSGE DDLVTAPANI SNSTWSSALH QTLSNMVSQA QSHHEAPKSQ
1700
1701
EDTICTMFYY PQKIPNKPEF EDSNPSPLPP DMAPGQSYQP QSESASSSSM
1750
1751
DKYHIHHISE PTRQENWTPL KNDLENHLED FELEVELLIT LIKSEKGSLG
1800
1801
FTVTKGNQRI GCYVHDVIQD PAKSDGRLKP GDRLIKVNDT DVTNMTHTDA
1850
1851
VNLLRAASKT VRLVIGRVLE LPRIPMLPHL LPDITLTCNK EELGFSLCGG
1900
1901
HDSLYQVVYI SDINPRSVAA IEGNLQLLDV IHYVNGVSTQ GMTLEEVNRA
1950
1951
LDMSLPSLVL KATRNDLPVV PSSKRSAVSA PKSTKGNGSY SVGSCSQPAL
2000
2001
TPNDSFSTVA GEEINEISYP KGKCSTYQIK GSPNLTLPKE SYIQEDDIYD
2050
2051
DSQEAEVIQS LLDVVDEEAQ NLLNENNAAG YSCGPGTLKM NGKLSEERTE
2100
2101
DTDCDGSPLP EYFTEATKMN GCEEYCEEKV KSESLIQKPQ EKKTDDDEIT
2150
2151
WGNDELPIER TNHEDSDKDH SFLTNDELAV LPVVKVLPSG KYTGANLKSV
2200
2201
IRVLRGLLDQ GIPSKELENL QELKPLDQCL IGQTKENRRK NRYKNILPYD
2250
2251
ATRVPLGDEG GYINASFIKI PVGKEEFVYI ACQGPLPTTV GDFWQMIWEQ
2300
2301
KSTVIAMMTQ EVEGEKIKCQ RYWPNILGKT TMVSNRLRLA LVRMQQLKGF
2350
2351
VVRAMTLEDI QTREVRHISH LNFTAWPDHD TPSQPDDLLT FISYMRHIHR
2400
2401
SGPIITHCSA GIGRSGTLIC IDVVLGLISQ DLDFDISDLV RCMRLQRHGM
2450
2451
VQTEDQYIFC YQVILYVLTR LQAEEEQKQQ PQLLK                
2485
 

Show the unformatted sequence.

Checksums:
CRC64:8D1B31597C66962B
MD5:ba5d121bb5777016fc5cd6b5c2fea453

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PDZ 1368 - 1450 1D5G A 8 - 90 Jmol AstexViewer SPICE
1Q7X A 12 - 99 Jmol AstexViewer SPICE
3LNX A 8 - 90 Jmol AstexViewer SPICE
B 8 - 90 Jmol AstexViewer SPICE
C 8 - 90 Jmol AstexViewer SPICE
D 8 - 90 Jmol AstexViewer SPICE
E 8 - 90 Jmol AstexViewer SPICE
F 8 - 90 Jmol AstexViewer SPICE
3LNY A 8 - 90 Jmol AstexViewer SPICE
3PDZ A 8 - 90 Jmol AstexViewer SPICE
Y_phosphatase 2237 - 2466 1WCH A 2237 - 2466 Jmol AstexViewer SPICE