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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TRAF2_HUMAN (Q12933)

Summary

This is the summary of UniProt entry TRAF2_HUMAN (Q12933).

Description: TNF receptor-associated factor 2 EC=6.3.2.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 501 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A zf-C3HC4 34 72
Pfam A zf-TRAF 178 235
coiled_coil n/a 307 327
Pfam A MATH 358 498

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q12933. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG
50
51
HRYCSFCLAS ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV
100
101
ESLPAVCPSD GCTWKGTLKE YESCHEGRCP LMLTECPACK GLVRLGEKER
150
151
HLEHECPERS LSCRHCRAPC CGADVKAHHE VCPKFPLTCD GCGKKKIPRE
200
201
KFQDHVKTCG KCRVPCRFHA IGCLETVEGE KQQEHEVQWL REHLAMLLSS
250
251
VLEAKPLLGD QSHAGSELLQ RCESLEKKTA TFENIVCVLN REVERVAMTA
300
301
EACSRQHRLD QDKIEALSSK VQQLERSIGL KDLAMADLEQ KVLEMEASTY
350
351
DGVFIWKISD FARKRQEAVA GRIPAIFSPA FYTSRYGYKM CLRIYLNGDG
400
401
TGRGTHLSLF FVVMKGPNDA LLRWPFNQKV TLMLLDQNNR EHVIDAFRPD
450
451
VTSSSFQRPV NDMNIASGCP LFCPVSKMEA KNSYVRDDAI FIKAIVDLTG
500
501
L                                                     
501
 

Show the unformatted sequence.

Checksums:
CRC64:C508BE185B783B20
MD5:3112349e6eb9f0ca7f019c9ae9720195

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MATH 358 - 498 1CA4 A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
D 358 - 498 Jmol AstexViewer SPICE
E 358 - 498 Jmol AstexViewer SPICE
F 358 - 498 Jmol AstexViewer SPICE
1CA9 A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
D 358 - 498 Jmol AstexViewer SPICE
E 358 - 498 Jmol AstexViewer SPICE
F 358 - 498 Jmol AstexViewer SPICE
1CZY A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
1CZZ A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
1D00 A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
D 358 - 498 Jmol AstexViewer SPICE
E 358 - 498 Jmol AstexViewer SPICE
F 358 - 498 Jmol AstexViewer SPICE
G 358 - 498 Jmol AstexViewer SPICE
H 358 - 498 Jmol AstexViewer SPICE
1D01 A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
D 358 - 498 Jmol AstexViewer SPICE
E 358 - 498 Jmol AstexViewer SPICE
F 358 - 498 Jmol AstexViewer SPICE
1D0A A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
D 358 - 498 Jmol AstexViewer SPICE
E 358 - 498 Jmol AstexViewer SPICE
F 358 - 498 Jmol AstexViewer SPICE
1D0J A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
D 358 - 498 Jmol AstexViewer SPICE
E 358 - 498 Jmol AstexViewer SPICE
F 358 - 498 Jmol AstexViewer SPICE
1F3V B 358 - 498 Jmol AstexViewer SPICE
1QSC A 358 - 498 Jmol AstexViewer SPICE
B 358 - 498 Jmol AstexViewer SPICE
C 358 - 498 Jmol AstexViewer SPICE
zf-C3HC4 34 - 72 3KNV A 34 - 72 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.