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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTPRS_HUMAN (Q13332)

Summary

This is the summary of UniProt entry PTPRS_HUMAN (Q13332).

Description: Receptor-type tyrosine-protein phosphatase S EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1948 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 29
low_complexity n/a 6 26
Pfam A I-set 33 124
disorder n/a 38 40
disorder n/a 63 70
Pfam A I-set 135 234
disorder n/a 136 143
disorder n/a 154 157
disorder n/a 183 189
disorder n/a 196 205
disorder n/a 212 214
low_complexity n/a 234 243
Pfam A I-set 245 328
disorder n/a 279 282
disorder n/a 284 297
Pfam A fn3 333 414
disorder n/a 333 340
disorder n/a 342 351
disorder n/a 375 380
disorder n/a 412 433
Pfam A fn3 428 513
disorder n/a 471 479
disorder n/a 512 533
Pfam A fn3 526 606
disorder n/a 535 542
disorder n/a 570 578
disorder n/a 605 625
Pfam A fn3 619 708
disorder n/a 638 642
disorder n/a 648 659
disorder n/a 661 677
disorder n/a 696 728
low_complexity n/a 701 713
Pfam A fn3 721 821
disorder n/a 752 754
disorder n/a 760 762
disorder n/a 764 765
disorder n/a 771 782
disorder n/a 790 793
disorder n/a 825 826
Pfam A fn3 835 917
disorder n/a 836 840
disorder n/a 843 854
disorder n/a 863 866
disorder n/a 877 887
disorder n/a 889 890
disorder n/a 915 938
Pfam A fn3 930 1022
disorder n/a 976 994
disorder n/a 1006 1015
disorder n/a 1017 1019
disorder n/a 1021 1023
disorder n/a 1026 1028
Pfam B Pfam-B_10280 1141 1189
coiled_coil n/a 1181 1201
low_complexity n/a 1189 1202
disorder n/a 1227 1231
disorder n/a 1261 1265
disorder n/a 1268 1273
transmembrane n/a 1283 1306
low_complexity n/a 1290 1305
disorder n/a 1315 1329
disorder n/a 1336 1350
disorder n/a 1408 1411
Pfam A Y_phosphatase 1416 1647
Pfam B Pfam-B_4051 1666 1699
Pfam A Y_phosphatase 1705 1938

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13332. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA
50
51
SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR
100
101
DENVYECVAQ NSVGEITVHA KLTVLREDQL PSGFPNIDMG PQLKVVERTR
150
151
TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSE TFESTPIRGA
200
201
LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV RRVAPRFSIL
250
251
PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL
300
301
TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI
350
351
TWDSGNPDPV SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI
400
401
WVSAVNSIGQ GPPSESVVTR TGEQAPASAP RNVQARMLSA TTMIVQWEEP
450
451
VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV DDSLLTTVGS LLEDETYTVR
500
501
VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS ITLSWSPPRQ
550
551
ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ
600
601
GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA
650
651
LVGYSVRYRP LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT
700
701
EVGPGPESSP VVVRTDEDVP SAPPRKVEAE ALNATAIRVL WRSPAPGRQH
750
751
GQIRGYQVHY VRMEGAEARG PPRIKDVMLA DAQWETDDTA EYEMVITNLQ
800
801
PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV QQTPEGSLLA
850
851
RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT
900
901
YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW
950
951
LPPVPAERNG AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL
1000
1001
KPDTAYDLQV RAHTRRGPGP FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV
1050
1051
LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR TTKKLITHLK PHTFYNFVLT
1100
1101
NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV YLPDGQSPVP
1150
1151
VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR
1200
1201
QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL
1250
1251
QKSEPTFAAS PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV
1300
1301
IAILLYKNKP DSKRKDSEPR TKCLLNNADL APHHPKDPVE MRRINFQTPD
1350
1351
SGLRSPLREP GFHFESMLSH PPIPIADMAE HTERLKANDS LKLSQEYESI
1400
1401
DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG IMGSDYINAN
1450
1451
YVDGYRCQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK
1500
1501
CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF
1550
1551
QFTAWPDHGV PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI
1600
1601
VIDAMLERIK PEKTVDVYGH VTLMRSQRNY MVQTEDQYSF IHEALLEAVG
1650
1651
CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM ELEFKRLANS KAHTSRFISA
1700
1701
NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF IDGYRQQKAY
1750
1751
IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA
1800
1801
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP
1850
1851
KSGEGFIDFI GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM
1900
1901
RYEGVVDIFQ TVKMLRTQRP AMVQTEDEYQ FCYQAALEYL GSFDHYAT  
1948
 

Show the unformatted sequence.

Checksums:
CRC64:E8BFA76CA410C457
MD5:3b51075a0bccc9cc5e21fccab6072388

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
I-set 135 - 228 2YD3 A 135 - 219 Jmol AstexViewer SPICE
135 - 231 2YD2 A 135 - 222 Jmol AstexViewer SPICE
135 - 234 2YD9 A 135 - 225 Jmol AstexViewer SPICE
245 - 321 2YD9 A 232 - 308 Jmol AstexViewer SPICE
33 - 124 2YD2 A 33 - 124 Jmol AstexViewer SPICE
2YD3 A 33 - 124 Jmol AstexViewer SPICE
2YD9 A 33 - 124 Jmol AstexViewer SPICE
Y_phosphatase 1416 - 1647 2FH7 A 1416 - 1647 Jmol AstexViewer SPICE
1705 - 1938 2FH7 A 1705 - 1938 Jmol AstexViewer SPICE