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20  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FKBP5_HUMAN (Q13451)

Summary

This is the summary of UniProt entry FKBP5_HUMAN (Q13451).

Description: Peptidyl-prolyl cis-trans isomerase FKBP5 EC=5.2.1.8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 457 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 24
disorder n/a 36 37
Pfam A FKBP_C 43 135
disorder n/a 65 66
disorder n/a 153 156
Pfam A FKBP_C 158 248
disorder n/a 158 164
disorder n/a 202 203
Pfam A TPR_1 318 350
Pfam A TPR_1 351 384
disorder n/a 391 394
disorder n/a 421 457

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q13451. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG
50
51
DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG
100
101
EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR
150
151
RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI
200
201
GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF
250
251
EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM
300
301
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN
350
351
EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE
400
401
HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE
450
451
EKPEGHV                                               
457
 

Show the unformatted sequence.

Checksums:
CRC64:18A86608C6891A73
MD5:2f93709b76736e8175c78afbfbd86168

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FKBP_C 158 - 248 1KT0 A 158 - 248 Jmol AstexViewer SPICE
3O5D A 158 - 248 Jmol AstexViewer SPICE
B 158 - 248 Jmol AstexViewer SPICE
43 - 135 3O5D A 43 - 135 Jmol AstexViewer SPICE
B 43 - 135 Jmol AstexViewer SPICE
3O5E A 43 - 135 Jmol AstexViewer SPICE
3O5F A 43 - 135 Jmol AstexViewer SPICE
3O5G A 43 - 135 Jmol AstexViewer SPICE
3O5I A 43 - 135 Jmol AstexViewer SPICE
B 43 - 135 Jmol AstexViewer SPICE
3O5J A 43 - 135 Jmol AstexViewer SPICE
3O5K A 43 - 135 Jmol AstexViewer SPICE
B 43 - 135 Jmol AstexViewer SPICE
C 43 - 135 Jmol AstexViewer SPICE
D 43 - 135 Jmol AstexViewer SPICE
3O5L A 43 - 135 Jmol AstexViewer SPICE
3O5M A 43 - 135 Jmol AstexViewer SPICE
B 43 - 135 Jmol AstexViewer SPICE
3O5O A 43 - 135 Jmol AstexViewer SPICE
3O5P A 43 - 135 Jmol AstexViewer SPICE
3O5Q A 43 - 135 Jmol AstexViewer SPICE
3O5R A 43 - 135 Jmol AstexViewer SPICE
4DRK A 43 - 135 Jmol AstexViewer SPICE
B 43 - 135 Jmol AstexViewer SPICE
4DRM A 43 - 135 Jmol AstexViewer SPICE
4DRN A 43 - 135 Jmol AstexViewer SPICE
4DRO A 43 - 135 Jmol AstexViewer SPICE
4DRP A 43 - 135 Jmol AstexViewer SPICE
4DRQ A 43 - 135 Jmol AstexViewer SPICE
46 - 135 1KT0 A 46 - 135 Jmol AstexViewer SPICE
TPR_1 318 - 350 1KT0 A 318 - 350 Jmol AstexViewer SPICE
351 - 381 1KT0 A 351 - 381 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.